Arsenic relative bioavailability from diet and airborne exposures: Implications for risk assessment

Yager, Janice W.; Greene, Tracy; Schoof, Rosalind A.

doi:10.1016/j.scitotenv.2015.05.141

Cited by 35 publications

(22 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have been conducted on the bioaccessibility of arsenic species from various food in vitro (see Yager et al, 2015, for a detailed overview) and those referring specifically to iAs are summarized in Table 1. Although these studies are not useful for estimating the amount of iAs that enters systemic circulation, they do provide information about the release of bound arsenic from food under various conditions and factors that can modulate the amount of iAs available for intestinal absorption, such as Fe 3+ concentration (Alava et al, 2013).…”

Section: Fate Of Ingested Inorganic Arsenic and Biomarkers Of Exposurementioning

confidence: 99%

Human exposure to dietary inorganic arsenic and other arsenic species: State of knowledge, gaps and uncertainties

Cubadda

Jackson

Cottingham

et al. 2017

Science of The Total Environment

205

113

View full text Add to dashboard Cite

Inorganic arsenic (iAs) is ubiquitous in the environment as arsenite (AsIII) and arsenate (AsV) compounds and biotransformation of these toxic chemicals leads to the extraordinary variety of organoarsenic species found in nature. Despite classification as a human carcinogen based on data from populations exposed through contaminated drinking water, only recently has a need for regulatory limits on iAs in food been recognized. The delay was due to the difficulty in risk assessment of dietary iAs, which critically relies on speciation analysis providing occurrence data for iAs in food – and not simply for total arsenic. In the present review the state of knowledge regarding arsenic speciation in food and diet is evaluated with focus on iAs and human exposure assessment through different dietary approaches including duplicate diet studies, market basket surveys, and total diet studies. The analytical requirements for obtaining reliable data for iAs in food are discussed and iAs levels in foods and beverages are summarized, along with information on other (potentially) toxic co-occurring organoarsenic compounds. Quantitative exposure assessment of iAs in food is addressed, focusing on the need of capturing variability and extent of exposure and identifying what dietary items drive very high exposure for certain population groups. Finally, gaps and uncertainties are discussed, including effect of processing and cooking, and iAs bioavailability.

show abstract

Section: Fate Of Ingested Inorganic Arsenic and Biomarkers Of Exposurementioning

confidence: 99%

Human exposure to dietary inorganic arsenic and other arsenic species: State of knowledge, gaps and uncertainties

Cubadda

Jackson

Cottingham

et al. 2017

Science of The Total Environment

205

113

View full text Add to dashboard Cite

show abstract

“…Coal ash is one of the most abundant of industrial wastes; close to 130 million tons 52 of coal fly was generated in the USA in 2014, with 100 million tons estimated from the European Union in 2011 53 . Arsenic concentrates in the fly ash during combustion of coal for energy; the median arsenic concentration in USA fly ash is 71 mg/kg 54 . Fly ash is often sluiced into settling basins, and because arsenic in fresh ash is quite soluble, wastewater arsenic concentrations can consequently be quite high.…”

Section: Anthropogenic Sources Of Arsenic To Soilmentioning

confidence: 99%

Understanding arsenic dynamics in agronomic systems to predict and prevent uptake by crop plants

Punshon

Jackson

Meharg

et al. 2017

Science of The Total Environment

205

View full text Add to dashboard Cite

This review is on arsenic in agronomic systems, and covers processes that influence the entry of arsenic into the human food supply. The scope is from sources of arsenic (natural and anthropogenic) in soils, biogeochemical and rhizosphere processes that control arsenic speciation and availability, through to mechanisms of uptake by crop plants and potential mitigation strategies. This review makes a case for taking steps to prevent or limit crop uptake of arsenic, wherever possible, and to work toward a long-term solution to the presence of arsenic in agronomic systems. The past two decades have seen important advances in our understanding of how biogeochemical and physiological processes influence human exposure to soil arsenic, and this must now prompt an informed reconsideration and unification of regulations to protect the quality of agricultural and residential soils.

show abstract

“…It is one of the world’s oldest known carcinogens [1] and it is classified as a class I carcinogen [2]. Humans can be exposed to arsenic by drinking contaminated water [3], inhaling certain substances in occupational settings [2], ingesting contaminated food (summarized in [4]) and using tobacco products [5]. It is estimated that approximately 200 million people in the world are exposed to drinking water contaminated with potentially harmful levels of arsenic [6].…”

Section: Introductionmentioning

confidence: 99%

Inorganic arsenic inhibits the nucleotide excision repair pathway and reduces the expression of XPC

et al. 2017

View full text Add to dashboard Cite

Chronic exposure to arsenic, most often through contaminated drinking water, has been linked to several types of cancer in humans, including skin and lung cancer. However, the mechanisms underlying its role in causing cancer are not well understood. There is evidence that exposure to arsenic can enhance the carcinogenicity of UV light in inducing skin cancers and may enhance the carcinogenicity of tobacco smoke in inducing lung cancers. The nucleotide excision repair (NER) pathway removes different types of DNA damage including those produced by UV light and components of tobacco smoke. The aim of the present study was to investigate the effect of sodium arsenite on the NER pathway in human lung fibroblasts (IMR-90 cells) and primary mouse keratinocytes. To measure NER, we employed a slot-blot assay to quantify the introduction and removal of UV light-induced 6-4 photoproducts (6-4 PP) and cyclobutane pyrimidine dimers (CPDs). We find a concentration-dependent inhibition of the removal of 6-4 PPs and CPDs in both cell types treated with arsenite. Treatment of both cell types with arsenite resulted in a significant reduction in the abundance of XPC, a protein that is critical for DNA damage recognition in NER. The abundance of RNA expressed from several key NER genes was also significantly reduced by treatment of IMR-90 cells with arsenite. Finally, treatment of IMR-90 cells with MG-132 abrogated the reduction in XPC protein, suggesting an involvement of the proteasome in the reduction of XPC protein produced by treatment of cells with arsenic. The inhibition of NER by arsenic may reflect one mechanism underlying the role of arsenic exposure in enhancing cigarette smoke-induced lung carcinogenesis and UV light-induced skin cancer, and it may provide some insights into the emergence of arsenic trioxide as a chemotherapeutic agent.

show abstract

Arsenic relative bioavailability from diet and airborne exposures: Implications for risk assessment

Cited by 35 publications

References 92 publications

Human exposure to dietary inorganic arsenic and other arsenic species: State of knowledge, gaps and uncertainties

Human exposure to dietary inorganic arsenic and other arsenic species: State of knowledge, gaps and uncertainties

Understanding arsenic dynamics in agronomic systems to predict and prevent uptake by crop plants

Inorganic arsenic inhibits the nucleotide excision repair pathway and reduces the expression of XPC

Contact Info

Product

Resources

About