Arsenic-induced toxicity in the endometrium of adult albino rat and the possible role of human chorionic gonadotropin hormone

Elshawarby, Amany M.; Saleh, Hanan; Attia, Azza A.; Negm, Eman

doi:10.1097/01.ehx.0000446582.73701.1b

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…Moreover, studies have shown that these structures are controlled by progesterone and may indicate endometrial maturity in response to this hormone (Da Broi et al, 2017). The pinopode expression coincides with reduced progesterone receptors (Elshawarby, Saleh, Attia, & Negm, 2014), whereas the administration of antiprogestin and estrogen reduces pinopode expression (Mohd Helmy, 2016) the pregnancy rate in stimulated IVF cycles (Tropea et al, 2004). On the contrary, during hormone replacement therapy with gonadotropin releasing hormone-analog, estrogen, and progesterone, pinopode expression was noted later (Table 2; Nardo et al, 2002; Tables 3 and 4).…”

Section: Hormones and Pinopodementioning

confidence: 99%

“…Moreover, studies have shown that these structures are controlled by progesterone and may indicate endometrial maturity in response to this hormone (Da Broi et al, ). The pinopode expression coincides with reduced progesterone receptors (Elshawarby, Saleh, Attia, & Negm, ), whereas the administration of antiprogestin and estrogen reduces pinopode expression (Mohd Helmy, ). In the cycle that is induced by controlled ovarian heperstimulation (COH; clomiphene citrate [CC] + human menopausal gonadotropin + human chorionic gonadotropin) advanced endometrial histological features and premature appearance of endometrial pinopodes are observed in the early luteal phase of COH cycles, with the absence of normal pinopode formation at the time of expected implantation.…”

Section: Hormones and Pinopodementioning

confidence: 99%

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Endometrial pinopode biomarkers: Molecules and microRNAs

Rarani

Borhani

Rashidi

2018

Journal Cellular Physiology

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Ultrastructural changes on the apical surface of the luminal epithelium of the uterus are known as pinopodes. Their morphology in species and in special species is associated with different results about size, duration, and percentage of surface area covered by pinopodes. The content of pinopodes is different in rodents and humans. In mice and rats pinopodes have many vacuoles and no organelle that extends to the actin stalk above the microvilli. Human pinopodes do not have a large vacuole and contain the golgi complex, a rough endoplasmic reticulum, secretory vesicles, and mitochondria that extend from the entire cell surface. It has been suggested that pinopodes are good markers of endometrial receptivity and implantation window. There are several molecular markers related to the presence of pinopodes, including integrins, leukemia inhibiting factor (LIF), l-selectin, HOXA10, glutaredoxin, glycodelinA, heparin-binding epidermal growth factor, mucins, and microRNAs (miRNAs). Multiple lines of evidence have indicated that miRNAs could affect the expression of LIF and pinopodes in the endometrium and these molecules play key roles in implantation window processes. Here, we have summarized the morphology and function of pinopodes. Moreover, we have highlighted several molecules in relation to pinopodes that could be used as biomarkers.

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