Arsenic-induced changes in optic tectal histoarchitecture and acetylcholinesterase–acetylcholine profile in Channa punctatus: Amelioration by selenium

Roy, Sonali; Chattoraj, Asamanja; Bhattacharya, Shelley

doi:10.1016/j.cbpc.2006.04.018

Cited by 28 publications

(15 citation statements)

References 40 publications

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“…Previous studies also report that copper and mercury are strong ChE inhibitors [28, 29]. Although the data showed that arsenic and lead caused lower inhibition of ChE activity, other studies have proved the toxicity of these metals towards ChE [30–32]. Thus, at the concentration of 5 mg/L, it can be summarised that the toxicity of the tested metals is as follows: Cu ≤ Hg ≤ Cr < Cd < Ag ≤ Zn < As ≤ Pb.…”

Section: Resultsmentioning

confidence: 99%

The Assessment of Cholinesterase from the Liver ofPuntius Javanicusas Detection of Metal Ions

Sabullah

Sulaiman

Shukor

et al. 2014

The Scientific World Journal

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Crude extract of ChE from the liver of Puntius javanicus was purified using procainamide-sepharyl 6B. S-Butyrylthiocholine iodide (BTC) was selected as the specific synthetic substrate for this assay with the highest maximal velocity and lowest biomolecular constant at 53.49 µmole/min/mg and 0.23 mM, respectively, with catalytic efficiency ratio of 0.23. The optimum parameter was obtained at pH 7.5 and optimal temperature in the range of 25 to 30°C. The effect of different storage condition was assessed where ChE activity was significantly decreased after 9 days of storage at room temperature. However, ChE activity showed no significant difference when stored at 4.0, 0, and −25°C for 15 days. Screening of heavy metals shows that chromium, copper, and mercury strongly inhibited P. javanicus ChE by lowering the activity below 50%, while several pairwise combination of metal ions exhibited synergistic inhibiting effects on the enzyme which is greater than single exposure especially chromium, copper, and mercury. The results showed that P. javanicus ChE has the potential to be used as a biosensor for the detection of metal ions.

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Section: Resultsmentioning

confidence: 99%

The Assessment of Cholinesterase from the Liver ofPuntius Javanicusas Detection of Metal Ions

Sabullah

Sulaiman

Shukor

et al. 2014

The Scientific World Journal

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“…Both arsenite and arsenate can cause cholinergic dysfunctions in rats in a dose dependent manner, with concomitant AChE inhibition [21, 133, 134] and consequent disturbances in nervous activity [135]. Increased blood ALAS levels [26] and changes in ALAD activity have been noted upon exposure to both As (III) and (V) [136] and it has been posited that ALAD activity in blood may be used to estimate its enzymatic brain activity [40].…”

Section: Biomarkers For Lead (Pb) Arsenic (As) and Manganese (Mn)mentioning

confidence: 99%

Lead, Arsenic, and Manganese Metal Mixture Exposures: Focus on Biomarkers of Effect

Andrade

Mateus

Batoréu

et al. 2015

Biol Trace Elem Res

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Summary The increasing exposure of human populations to excessive levels of metals continues to represent a matter of public health concern. Several biomarkers have been studied and proposed for the detection of adverse health effects induced by lead (Pb), arsenic (As) and manganese (Mn); however, these studies have relied on exposures to each single metal, which fails to replicate real-life exposure scenarios. These 3 metals are commonly detected in different environmental, occupational and food contexts and they share common neurotoxic effects, which are progressive and once clinically apparent may be irreversible. Thus, chronic exposure to low levels of a mixture of these metals represents an additive risk of toxicity. Building upon their shared mechanisms of toxicity, such as oxidative stress, interference with neurotransmitters and effects on hematopoietic system, we address putative biomarkers, which may be assist in assessing onset of neurological diseases associated with exposure to this metal mixture.

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“…It is remarkable that AChE is also readily inhibited by arsenite even, though this enzyme contains no lipoic acid and no sulfhydryl groups (Page and Wilson 1985). Roy et al (2006) recently reported significant dose-dependent increase in AChE activity at 1/10 and 1/20 LC 50 dosages of arsenic on day 1, a decrease on day 2 and regained activity on day 7 reaching the basal level on day 14. Moreover, Fish Physiol Biochem (2007) Roy et al (2006) further demonstrated arsenic to be an agent of intoxication signals, exemplified by aberration in the brain AChE-ACh system, strongly correlating with the histoarchitectural damage recorded in the optic tectum.…”

Section: The Effect Of Arsenic In Fishmentioning

confidence: 97%

Arsenic-induced responses in freshwater teleosts

Bhattacharya

Roy

2007

Fish Physiol Biochem

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The environment is currently polluted by thousands of chemicals or xenobiotics introduced into the environment by man to meet the demands of the modern era. Every day we encounter this negative side of human civilization, but have done little to lessen the rate of pollution. Although the entire biosphere is polluted it is water resources that are the most polluted because water is the ultimate sink for many contaminants. Thus, fish are the most vulnerable of all animal species. They are helpless because they cannot avoid the polluted habitat and face this contamination by default. Nevertheless, fish are found to survive under extreme conditions when their natural habitat has been compromised to a great extent. However, fish are highly sensitive to small environmental changes and their populations gradually dwindle if pollution continues unabated. However, we know that there are instances when water is cleaned and the rate of repopulation by different fish species has gained momentum, restoring the ecological balance. Thus, fish are considered reliable bioindicators of water pollution and fish ecotoxicology has received much attention in recent years, and fish toxicology has been able to defend a significant position in the arena of xenobiotics research over the years. This review deals with some of the major intoxication and detoxication signals manifested by fish exposed to arsenic (As), which is presently one of the most worrying metalloids in water pollution.

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Arsenic-induced changes in optic tectal histoarchitecture and acetylcholinesterase–acetylcholine profile in Channa punctatus: Amelioration by selenium

Cited by 28 publications

References 40 publications

The Assessment of Cholinesterase from the Liver ofPuntius Javanicusas Detection of Metal Ions

The Assessment of Cholinesterase from the Liver ofPuntius Javanicusas Detection of Metal Ions

Lead, Arsenic, and Manganese Metal Mixture Exposures: Focus on Biomarkers of Effect

Arsenic-induced responses in freshwater teleosts

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