Arsenic in the aetiology of cancer

Tapio, Soile; Grosche, Bernd

doi:10.1016/j.mrrev.2006.02.001

Cited by 294 publications

(169 citation statements)

References 297 publications

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“…In contrast, we did not find an increased risk of lung and bladder/kidney cancers otherwise shown to be associated with chronic arsenic exposure [2,3] or early-life arsenic exposure [20]. The lack of association might be derived from dilution in a population less than 53 years of age, or the effects of intensive follow-up of affected patients, where early detection may concentrate on lung and bladder/kidney cancers, which might lead to better prognosis (since these cancers are suspected effects of arsenic).…”

Section: Discussioncontrasting

confidence: 99%

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Cancer excess after arsenic exposure from contaminated milk powder

Yorifuji

Tsuda

Doi

et al. 2010

Environ Health Prev Med

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Objectives Long-term exposure to inorganic arsenic is related to increased risk of cancer in the lung, skin, bladder, and, possibly, other sites. However, little is known about the consequences of developmental exposures in regard to cancer risk. During early summer in 1955, mass arsenic poisoning of infants occurred in the western part of Japan because of contaminated milk powder. Okayama Prefecture was most severely affected. We examined whether the affected birth cohorts in this prefecture experienced increased cancer mortality. Methods We targeted subjects who were born from September 1950 to August 1960 and died in Okayama Prefecture between January 1969 and March 2008 due to malignant neoplasm (N = 3,141). We then compared cancer mortality (total, liver, pancreatic, lung, bladder/ kidney, and hematopoietic cancers) between cohorts born before the milk poisoning (exposed group) and cohorts born after the poisoning (nonexposed group). We estimated mortality ratios and 95% confidence intervals. Results Total and liver cancers were elevated in the cohort up to 1 year of age at time of the poisoning. In addition, pancreatic and hematopoietic cancers were elevated in the cohorts up to 5 years of age, and mortality ratios were approximately twice those of the nonexposed group. Increased risk of lung and bladder/kidney cancers was not apparent. Conclusions Although dilution is present in these cohortbased data, our study highlights the notion that developmental arsenic exposure may lead to a different pattern of cancer, including increases in pancreatic and hematopoietic cancer, as compared with adult or lifetime exposures to inorganic arsenic.

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Section: Discussioncontrasting

confidence: 99%

“…Long-term exposure to inorganic arsenic through inhalation or drinking-water ingestion is causally related to increased risk of cancer in the lung, skin, and bladder [1][2][3]. Although the evidence is less convincing, an association between inorganic arsenic and increased risk of kidney, liver, and prostate cancer is also possible [1].…”

Section: Introductionmentioning

confidence: 99%

Cancer excess after arsenic exposure from contaminated milk powder

Yorifuji

Tsuda

Doi

et al. 2010

Environ Health Prev Med

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“…It was impossible to evaluate whether observed differences between the three subgroups were due to quality of exposure assessment or due to differences in accumulated exposures. Previous studies have shown that arsenic and dust are important confounding factors when evaluating the radon-related lung cancer risk (Chen and Chen, 2002;Tapio and Grosche, 2006). Both dust and arsenic play a role in the working environment of the German uranium miners.…”

Section: Discussionmentioning

confidence: 99%

Lung cancer risk among German male uranium miners: a cohort study, 1946–1998

et al. 2006

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From 1946 to 1990 extensive uranium mining was conducted in the southern parts of the former German Democratic Republic. The overall workforce included several 100 000 individuals. A cohort of 59 001 former male employees of the Wismut Company was established, forming a large retrospective uranium miners' cohort for the time period 1946 -1998. Mean duration of follow-up was 30.5 years with a total of 1 801 630 person-years. Loss to follow-up was low at 5.3%. Of the workers, 16 598 (28.1%) died during the study period. Based on 2388 lung cancer deaths, the radon-related lung cancer risk is evaluated. The excess relative risk (ERR) per working level month (WLM) was estimated as 0.21% (95% CI: 0.18 -0.24). It was dependent on time since exposure and on attained age. The highest ERR/WLM was observed 15 -24 years after exposure and in the youngest age group (o55 years of age). While a strong inverse exposure-rate effect was detected for high exposures, no significant association was detected at exposures below 100 WLM. Excess relative risk /WLM was not modified by duration of exposure. The results would indicate the need to re-estimate the effects of risk modifying factors in current risk models as duration of exposure did not modify the ERR/WLM and there was only a modest decline of ERR/WLM with increasing time since exposure.

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“…Millions of people worldwide are exposed to high concentration of arsenic from groundwater, which the source of drinking water. Arsenic is widely distributed in nature and released into the environment through natural sources, industrial processes and agriculture usage (Singh et al 2010;Chio et al 2009;Chatterjee et al 1995;Mandal et al 1996;Duker et al 2005;Tapio and Grosche 2006). Continued ingestion of arsenic for a long period leads to chronic arsenic poisoning; acute poisoning typically include vomiting, oesophageal and abdominal pain, diarrhoea, skin lesions, cancer of the skin, lungs, urinary bladder, and kidney, as well as other skin changes such as pigmentation changes and thickening (hyperkeratosis), black foot disease (Rahman et al 2005;Atkins et al 2007;Yoshida et al 2004;Chaudhuri et al 2008;Pandey et al 2002;Jack et al 2003;Duker et al 2005;Tseng et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Biosorptive behaviour of mango leaf powder and rice husk for arsenic(III) from aqueous solutions

Kamsonlian

Suresh

Ramanaiah

et al. 2012

Int. J. Environ. Sci. Technol.

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The present study deals with the biosorption of As(III) from aqueous solution using mango leaves powder (MLP) and rice husk (RH) in a batch operation. Scanning electron microscopy and Fourier transformation infrared spectrometry analysis shows the surface texture of biosorbents and metal binding of functional groups of before and after biosorption of As(III). The optimum pH was obtained at 7 and 6 with 7 and 6 g/l of dosage of MLP and RH, respectively. The adsorption of As(III) onto MLP and RH was favourably influenced by an increase in temperature. Equilibrium data were well represented by the Freundlich isotherm model. Nitric acid and ethylenediaminetetra acetic acid was found to be a better eluant for the desorption followed by hydrochloric acid and sodium hydroxide of As(III) with a maximum desorption efficiency of 69.5, 48.5 and 79.4, 86.3 %, respectively. The pseudosecond-order kinetic model was found to best fitted of the experimental data over the equilibrium time at 32 h. The positive values of heat of adsorption (23.89 kJ/mol for MLP and 52.26 kJ/mol for RH) indicate the endothermic nature of the adsorption process. The thermodynamic study showed the spontaneous nature of the sorption of As(III) onto MLP and RH.

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Arsenic in the aetiology of cancer

Cited by 294 publications

References 297 publications

Cancer excess after arsenic exposure from contaminated milk powder

Cancer excess after arsenic exposure from contaminated milk powder

Lung cancer risk among German male uranium miners: a cohort study, 1946–1998

Biosorptive behaviour of mango leaf powder and rice husk for arsenic(III) from aqueous solutions

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