Arsenic geochemistry and human health in South East Asia

McCarty, Kathleen M.; Hanh, Hoang Thi; Kim, Kyoung-Woong

doi:10.1515/reveh.2011.010

Cited by 145 publications

(64 citation statements)

References 75 publications

(66 reference statements)

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“…Regions having rich ore deposits of certain metals tend to have these metals in groundwater due to the naturally occurring rock-water interaction. Arsenic is one such widely known lethal metal that occurs naturally in soil and causes severe health issues around the world especially affecting millions of lives in Asia (Fendorf et al 2010;McCarty et al 2011). Mining of metals from the ores and subsequent milling processes to remove the unwanted materials may also lead to the presence of such metals in soil and water around these areas (Stamatis et al 2001;Bird et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Human exposure risk to heavy metals through groundwater used for drinking in an intensively irrigated river delta

et al. 2016

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Drinking water containing heavy metals above the maximum permissible limits cause potential risk to human health. The aim of this study was to determine the groundwater suitability for drinking use based on heavy metal concentration and the associated human exposure risk in an intensively irrigated part of the Cauvery river basin, Tamil Nadu, India. Sixteen heavy metals analysed were in the order of dominance of chromiumChromium and zinc were within permissible limits of the Bureau of Indian Standards for drinking water quality, and silver, lead and nickel were above limits in all the groundwater samples. In less than 50 % of the groundwater samples, aluminium, boron, cadmium, copper, iron and manganese exceeded their individual permissible limits. Heavy metal pollution index based on 11 heavy metals indicated that groundwater quality of this area is poor-to-unsuitable. Non-carcinogenic risk for humans due to ingestion of groundwater through drinking water pathway was very high for infants, children and adults. Silver, lead, nickel, cadmium and manganese largely contributed to the health hazard. Sources of heavy metals were identified to be geological and from human activities, i.e., application of fertilizers in agricultural fields, seawater intrusion due to intensive pumping for agriculture and wastewater from industries. Groundwater and surface water in this area pose large threat due to high levels of heavy metals, and it is necessary to avoid this water for drinking due to potential risk of health hazard. This study also demonstrated the application of HPI and human exposure hazard index to study the groundwater quality based on heavy metals' concentration.

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Section: Introductionmentioning

confidence: 99%

Human exposure risk to heavy metals through groundwater used for drinking in an intensively irrigated river delta

et al. 2016

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“…Human exposure occurs from ingestion of water and food contaminated with As coming from natural and anthropogenic sources (IARC, 2012). Water pollution by As is a worldwide problem with high impact in the poorest regions of the world (Litter, 2010), with over 226 million persons exposed (Murcott, 2012;McCarty et al, 2011;Smedley and Kinnirugh, 2013). The highest concentrations and, consequently, the most important health problems are localized in Argentina, Bangladesh, Nepal, Chile, China, Hungary, India, Mexico, Rumania, Taiwan, Vietnam and the USA (Bundschuh et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of chronic disease related to arsenic in Argentina: A systematic review

Bardach

Ciapponi

Soto

et al. 2015

Science of The Total Environment

117

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“…It is either released through various natural processes such as weathering or hydrothermal emissions or generated by a number of anthropogenic activities such as the use of arsenic-containing pesticides, mining activities, and combustion of fossil fuels (1,2).…”

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Paralogous Regulators ArsR1 and ArsR2 of Pseudomonas putida KT2440 as a Basis for Arsenic Biosensor Development

Fernández

Morel

Ramos

et al. 2016

Appl Environ Microbiol

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The remarkable metal resistance of many microorganisms is related to the presence of multiple metal resistance operons. Pseudomonas putida KT2440 can be considered a model for these microorganisms since its arsenic resistance is due to the action of proteins encoded by the two paralogous arsenic resistance operons ARS1 and ARS2. Both operons contain the genes encoding the transcriptional regulators ArsR1 and ArsR2 that control operon expression. We show here that purified ArsR1 and ArsR2 bind the trivalent salt of arsenic (arsenite) with similar affinities (~30 M), whereas no binding is observed for the pentavalent salt (arsenate). Furthermore, trivalent salts of bismuth and antimony showed binding to both paralogues. The positions of cysteines, found to bind arsenic in other homologues, indicate that ArsR1 and ArsR2 employ different modes of arsenite recognition. Both paralogues are dimeric and possess significant thermal stability. Both proteins were used to construct whole-cell, lacZ-based biosensors. Whereas responses to bismuth were negligible, significant responses were observed for arsenite, arsenate, and antimony. Biosensors based on the P. putida arsB1 arsB2 arsenic efflux pump double mutant were significantly more sensitive than biosensors based on the wild-type strain. This sensitivity enhancement by pump mutation may be a convenient strategy for the construction of other biosensors. A frequent limitation found for other arsenic biosensors was their elevated background signal and interference by inorganic phosphate. The constructed biosensors show no interference by inorganic phosphate, are characterized by a very low background signal, and were found to be suitable to analyze environmental samples. IMPORTANCE Arsenic is at the top of the priority list of hazardous compounds issued by the U.S. Agency for Toxic Substances and Disease. The reason for the stunning arsenic resistance of many microorganisms is the existence of paralogous arsenic resistance operons.Pseudomonas putida KT2440 is a model organism for such bacteria, and their duplicated ars operons and in particular their ArsR transcription regulators have been studied in depth by in vivo approaches. Here we present an analysis of both purified ArsR paralogues by different biophysical techniques, and data obtained provide valuable insight into their structure and function. Particularly insightful was the comparison of ArsR effector profiles determined by in vitro and in vivo experimentation. We also report the use of both paralogues to construct robust and highly sensitive arsenic biosensors. Our finding that the deletion of both arsenic efflux pumps significantly increases biosensor sensitivity is of general relevance in the biosensor field.A rsenic is omnipresent in nature and found in many environmental biotopes such as seawater, freshwater, soils, and rocks. It is either released through various natural processes such as weathering or hydrothermal emissions or generated by a number of anthropogenic activities such as the use of arse...

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Arsenic geochemistry and human health in South East Asia

Cited by 145 publications

References 75 publications

Human exposure risk to heavy metals through groundwater used for drinking in an intensively irrigated river delta

Human exposure risk to heavy metals through groundwater used for drinking in an intensively irrigated river delta

Epidemiology of chronic disease related to arsenic in Argentina: A systematic review

Paralogous Regulators ArsR1 and ArsR2 of Pseudomonas putida KT2440 as a Basis for Arsenic Biosensor Development

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