Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan

Tseng, Chin‐Hsiao; Huang, Yung-Kai; Huang, Yali; Chung, Chi Jung; Yang, Mo; Chen, Chien Jen; Hsueh, Yu Mei

doi:10.1016/j.taap.2004.11.022

Cited by 261 publications

(175 citation statements)

References 74 publications

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“…Our analysis shows that as total urinary arsenic levels increase from o20 to 20-50 mg/l and to 450 mg/l, the percentage of the total urinary arsenic is increasingly due to arsenobetaine, with median percentages being 62.7% for total urinary arsenic levels 450 mg/l. The cut point of 50 mg/l was chosen because some studies suggest that slight health risks may be associated above this level (ACGIH, 2001;WHO, 2001;Tseng et al, 2005;Valenzuela et al, 2005) and also because this value has been used as an upper reference range. The cut point of 20 mg/l was chosen to correspond roughly to the 95th percentile of the sum of inorganic species; thus, a urine sample of o20 mg/l is likely to have little contribution from organic arsenic species.…”

Section: Discussionmentioning

confidence: 99%

Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004

Caldwell

Jones

Verdon

et al. 2008

J Expo Sci Environ Epidemiol

170

110

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Objective: To provide levels of total and speciated urinary arsenic in a representative sample of the US population. Methods: For the first time, total arsenic and seven inorganic and organic arsenic species were measured in the urine of participants (n ¼ 2557) for the [2003][2004] National Health and Nutrition Examination Survey (NHANES). Data were compiled as geometric means and selected percentiles of urinary arsenic concentrations (mg/l) and creatinine-corrected urinary arsenic (mg/g creatinine) for total arsenic, dimethylarsinic acid, arsenobetaine, and a sum of the inorganic related species. Results: Arsenic acid, arsenous acid, arsenocholine, and trimethylarsine oxide were detected in 7.6%, 4.6%, 1.8%, and 0.3% of the participants, respectively (the limits of detection of 0.6-1.2 mg/l). Monomethylarsonic acid was detected in 35% of the overall population. For all participants aged Z6 years, dimethylarsinic acid (geometric mean of 3.71 mg/l) and arsenobetaine (geometric mean of 1.55 mg/l) had the greatest contribution to the total urinary arsenic levels. A relatively greater percentage contribution from arsenobetaine is seen at higher total urinary arsenic levels and from dimethylarsinic acid at lower total urinary arsenic levels. For all participants aged Z6 years, the 95th percentiles for total urinary arsenic and the sum of inorganic-related arsenic (arsenic acid, arsenous acid, dimethylarsinic acid, and monomethylarsonic acid) were 65.4 and 18.9 mg/l, respectively. For total arsenic and dimethylarsinic acid, covariate-adjusted geometric means demonstrated several slight differences due to age, gender, and race/ethnicity. Conclusions: The data reflect relative background contributions of inorganic and seafood-related arsenic exposures in the US population. Arsenobetaine and dimethylarsinic acid are the major arsenic species present with arsenobetaine, accounting for a greater proportion of total arsenic as total arsenic levels increase. Keywords: speciated arsenic, human, urine, biomonitoring, NHANES. IntroductionArsenic is an element that is widely distributed in the earth's surface in small amounts, primarily in its inorganic forms. Anthropomorphic sources of arsenic have included the smelting of mined metals. Inorganic arsenic is used currently as an outdoor wood preservative, in some pesticides, as semiconductor dopant materials, and in certain medicines. General human exposure to inorganic arsenic results from natural amounts consumed in drinking water. However, dietary arsenic may be an important source (NRC, 2001) when drinking water levels are low. Arsenic also forms organic compounds through biological action on inorganic arsenic. These organic forms are found in fish, shellfish, seaweed, and aquatic sediments and are generally much less toxic. These dietary arsenic species are commonly represented by arsenobetaine and, to a lesser extent, by arsenocholine and arsenosugars (Heinrich-Ramm et al., 2002). In addition to the arsenical forms found in marine organisms, mono-and dimethylated pentava...

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Section: Discussionmentioning

confidence: 99%

Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004

Caldwell

Jones

Verdon

et al. 2008

J Expo Sci Environ Epidemiol

170

110

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“…Also, a higher proportion of urinary MA has been associated with higher risks of developing As-related diseases [117][118][119][120][121][122][123].…”

Section: Mechanisms and Toxicity Of Arsenic Compounds Occurring In Sementioning

confidence: 99%

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Molin

Ulven

Meltzer

et al. 2015

Journal of Trace Elements in Medicine and Biology

185

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“…Arsenic is widely distributed in nature and released into the environment through natural sources, industrial processes and agriculture usage (Singh et al 2010;Chio et al 2009;Chatterjee et al 1995;Mandal et al 1996;Duker et al 2005;Tapio and Grosche 2006). Continued ingestion of arsenic for a long period leads to chronic arsenic poisoning; acute poisoning typically include vomiting, oesophageal and abdominal pain, diarrhoea, skin lesions, cancer of the skin, lungs, urinary bladder, and kidney, as well as other skin changes such as pigmentation changes and thickening (hyperkeratosis), black foot disease (Rahman et al 2005;Atkins et al 2007;Yoshida et al 2004;Chaudhuri et al 2008;Pandey et al 2002;Jack et al 2003;Duker et al 2005;Tseng et al 2005). Because of high impact on human health even at low concentrations several regulating agencies set their maximum contamination level of arsenic in drinking water values e.g., World Health Organization as 0.01 mg/l, French as 0.015 mg/l, United State Environmental Protection Agency as 0.01 mg/l, Vietnam and Mexico as 0.05 mg/l, European Union as 0.01 mg/l, Australia as 0.007 mg/l, Germany as 0.01 mg/l, Bangladesh and India as 0.05 mg/l (Anawar et al 2003;Choong et al 2007;Maji et al 2008;Zhu et al 2009;Barakat and Sahiner 2008;Mohapatra et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Biosorptive behaviour of mango leaf powder and rice husk for arsenic(III) from aqueous solutions

Kamsonlian

Suresh

Ramanaiah

et al. 2012

Int. J. Environ. Sci. Technol.

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The present study deals with the biosorption of As(III) from aqueous solution using mango leaves powder (MLP) and rice husk (RH) in a batch operation. Scanning electron microscopy and Fourier transformation infrared spectrometry analysis shows the surface texture of biosorbents and metal binding of functional groups of before and after biosorption of As(III). The optimum pH was obtained at 7 and 6 with 7 and 6 g/l of dosage of MLP and RH, respectively. The adsorption of As(III) onto MLP and RH was favourably influenced by an increase in temperature. Equilibrium data were well represented by the Freundlich isotherm model. Nitric acid and ethylenediaminetetra acetic acid was found to be a better eluant for the desorption followed by hydrochloric acid and sodium hydroxide of As(III) with a maximum desorption efficiency of 69.5, 48.5 and 79.4, 86.3 %, respectively. The pseudosecond-order kinetic model was found to best fitted of the experimental data over the equilibrium time at 32 h. The positive values of heat of adsorption (23.89 kJ/mol for MLP and 52.26 kJ/mol for RH) indicate the endothermic nature of the adsorption process. The thermodynamic study showed the spontaneous nature of the sorption of As(III) onto MLP and RH.

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Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot disease-hyperendemic villages in Taiwan

Cited by 261 publications

References 74 publications

Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004

Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

Biosorptive behaviour of mango leaf powder and rice husk for arsenic(III) from aqueous solutions

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