Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals

Gao, Jianjun; Roy, Shantanu; Lin, Tong; Argos, Maria; Jasmine, Farzana; Rahaman, Ronald; Rakibuz-Zaman, Muhammad; Parvez, Faruque; Ahmed, Alauddin; Hore, Samar Kumar; Sarwar, Golam; Slavkovich, Vesna; Yunus, Muhammad; Rahman, Mahfuzar; Baron, John A.; Graziano, Joseph H.; Ahsan, Habibul; Pierce, Brandon L.

doi:10.1016/j.envres.2014.09.040

Cited by 42 publications

(33 citation statements)

References 69 publications

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“…In human atherosclerosis telomerase is activated and TERT expression correlates with the extent of the disease; however, the mechanisms underlying telomerase activation and the physiological role of inducible TERT expression in atherosclerosis remain to be discovered. 11,12 In correlation with these findings, this study suggests the association of increased hTERT expression with the increased risk of coronary artery diseases.…”

Section: Discussionsupporting

confidence: 77%

“…The association of telomere with atherosclerosis and CVD has been supported by a large number of studies. 5,11,12 Decreased hTERT mRNA expression and shorter telomere was found associated with atherosclerosis in various studies. 7,[24][25][26] In this study, among 50 study subjects, 31 patients were diagnosed with coronary artery diseases and the patients with CAD showed 4 fold higher hTERT mRNA expression than non-CAD patients.…”

Section: Discussionmentioning

confidence: 99%

“…Also, in people exposed to arsenic via drinking water (1−1000μg/L) in Inner Mongolia, TERT expression was positively associated with both arsenic concentrations in water and in nails and the severity of hyperkeratosis, a common arsenicrelated skin lesion. 10,11 Recent epidemiological studies have supported the role of telomere length and telomerase activity in cardiovascular disease pathogenesis. 5,7,12,13 Cardiovascular disease (CVD) in general and coronary artery disease (CAD) in particular is a leading cause of mortality and morbidity worldwide.…”

Section: Introductionmentioning

confidence: 99%

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Effect of arsenic exposure on human telomerase reverse transcriptase (hTERT) gene expression: Risk of cardiovascular diseases

Khaleda

Forkan

Wali

et al. 2019

Bangladesh Med Res Counc Bull

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Background: Exposure to inorganic arsenic (iAs) through drinking water is currently a serious threat to public health of millions of people worldwide including Bangladesh. Some recent studies have shown that telomere dysfunction is emerging as an important factor in the pathogenesis of different cardiovascular diseases. Arsenic plays significant role on telomere dysfunction by altering the expression of telomere-related genes. The study was aimed to investigate the effects of arsenic on hTERT mRNA levels and their combined role in increasing CVD susceptibility. Methods: In this cross sectional study, total of 50 CVD patients who underwent open heart surgery were recruited for this study. Urine, nail and cardiac tissue samples were collected and analyzed for As. Blood samples were quantified for hTERT expression analysis using real-time polymerase chain reaction. Results: The hTERT mRNA expression was found approx. 10 fold higher in the As-exposed patients than the As-unexposed patients (p<0.01). A strong positive correlation (p<0.01, R>0.3) was found between the hTERT mRNA levels and As contents in the cardiac tissue, nail and urine samples of the study subjects. The significant increase (approx. 4 fold) in the hTERT mRNA expression was found in the patients with coronary artery disease (CAD) than the non-CAD patients. Conclusions: The results of the study suggest that arsenic exposure increases hTERT mRNA expression which may in turn modify As-induced cardiovascular outcomes. The findings of this study will help to look deep into the association of As exposure in cardiovascular disease pathogenesis to open a new window in the diagnosis and treatment procedure of CVD. Bangladesh Med Res Counc Bull 2019; 45: 03-10

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of arsenic exposure on human telomerase reverse transcriptase (hTERT) gene expression: Risk of cardiovascular diseases

Khaleda

Forkan

Wali

et al. 2019

Bangladesh Med Res Counc Bull

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“…Interestingly, accumulating evidence indicates that leukocyte telomeric DNA may be one important target of environmental pollutants [ 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Highly Polluted Environment on Sperm Telomere Length: A Pilot Study

Vecoli

Montano²,

Borghini

et al. 2017

IJMS

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High environmental pressure may impair male fertility by affecting sperm quality, but the real effect remains controversial. Herein, we assessed the influence of environmental exposure on telomere length (TL) in both leukocytes (LTL) and sperm cells (STL). A pilot biomonitoring study was conducted in 112 clinically healthy, normospermic men living in various areas of Campania region (South of Italy) with high (n = 57, High Group) or low (n = 55, Low Group) environmental pressure. TL analysis was assessed by quantitative real time-PCR. STL was not significantly correlated with either age (p = 0.6) or LTL (p = 0.7), but was significantly longer in the High Group compared with the Low Group (p = 0.04). No significant difference was observed between leukocyte TL in the High or Low Group. Our results showed that male residents in areas with high environment exposure had a significant increase in STL. This finding supports the view that the human semen is a sentinel biomarker of environmental exposure.

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“…In vitro studies with arsenic, a common constituent of pesticides, showed increased telomerase activity and longer telomeres at low doses, but the opposite at higher doses [Li et al, ]. In support of these findings, Gao et al [] showed an increase in telomere length in individuals exposed to very high doses of arsenic in drinking water.…”

Section: Discussionmentioning

confidence: 93%

Telomere measurement in individuals occupationally exposed to pesticide mixtures in tobacco fields

Kahl

Simon

Salvador

et al. 2015

Environ and Mol Mutagen

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Occupational exposure to pesticides in tobacco fields causes genetic damage in farmers. The aim of this study was to analyze tobacco farmers chronically exposed to low doses of pesticides and nicotine (present in the tobacco leaves) in relation to absolute telomere length (aTL), and explore the influence of lifestyle characteristics, oxidative stress, and inorganic element levels. DNA was isolated from peripheral blood samples from agricultural workers and non-exposed individuals, and aTL was measured by quantitative real time polymerase chain reaction (qPCR) analysis. Oxidative stress (thiobarbituric acid reactive substances [TBARS], which measures oxidative damage to lipids; and toxic equivalent antioxidant capacity [TEAC], which measures total equivalent antioxidant capacity) was evaluated in serum, and inorganic element content was analyzed in whole blood through particle-induced X-ray emission technique. It was found that exposure to pesticides and tobacco smoking had significant effects on aTL. Individuals occupationally exposed to complex mixtures of pesticides in tobacco fields and individuals who smoked had decreased aTL compared with the non-exposed group. TBARS and TEAC were significantly elevated in the exposed group. There were no significant differences in inorganic elements. There was no evidence of an influence of age, gender, consumption of alcoholic beverages, or intake of fruits and vegetables on aTL within the groups. In addition, years of work in the tobacco field in the exposed group did not influence any of the variables analyzed. Although further studies were needed, these results suggested differences in telomere maintenance in tobacco farmers compared with the control group, indicating that telomere length may be a good biomarker of occupational exposure.

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Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals

Cited by 42 publications

References 69 publications

Effect of arsenic exposure on human telomerase reverse transcriptase (hTERT) gene expression: Risk of cardiovascular diseases

Effect of arsenic exposure on human telomerase reverse transcriptase (hTERT) gene expression: Risk of cardiovascular diseases

Effects of Highly Polluted Environment on Sperm Telomere Length: A Pilot Study

Telomere measurement in individuals occupationally exposed to pesticide mixtures in tobacco fields

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