Arsenic exposure diminishes ovarian follicular reserve and induces abnormal steroidogenesis by DNA methylation

Chen, Yiqin; Yan, Sun; Zhao, Aili; Cai, Xue-Fen; Yu, Aili; Xu, Qian; Wang, Panlin; Yao, Jing; Wang, Qi; Wang, Wenxiang

doi:10.1016/j.ecoenv.2022.113816

Cited by 26 publications

(17 citation statements)

References 48 publications

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“…[57][58][59] With respect to the ovarian reserve, examination of human and animal literatures suggests that environmental toxicants may accelerate folliculogenesis and follicular atresia, including in the primordial stage and extending across the spectrum of ovarian follicle development, 60 with mounting evidence pointing to impacts of specific EDCs such as arsenic. [61][62][63][64] The impact of EDCs on the acceleration of folliculogenesis and follicular atresia in particular is consistent with the current finding showing an initially higher AMH, which may result in greater ovarian follicle loss over time. Moreover, growing evidence shows that traffic pollutants, indexed by PM2.5 and shorter distances to roadways and longer distances to green spaces (ie, "buffer" zones), are associated with estimates of lower ovarian reserve.…”

Section: Discussionsupporting

confidence: 90%

“…Endocrine-disrupting chemicals (EDCs) are common in personal care and household products and may be particularly elevated among lower SES individuals 57-59 . With respect to the ovarian reserve, examination of human and animal literatures suggests that environmental toxicants may accelerate folliculogenesis and follicular atresia, including in the primordial stage and extending across the spectrum of ovarian follicle development, 60 with mounting evidence pointing to impacts of specific EDCs such as arsenic 61-64 . The impact of EDCs on the acceleration of folliculogenesis and follicular atresia in particular is consistent with the current finding showing an initially higher AMH, which may result in greater ovarian follicle loss over time.…”

Section: Discussionmentioning

confidence: 63%

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Association between neighborhood poverty and ovarian reserve: the ovarian aging study

Pan,

Crowder,

Cedars

et al. 2024

Menopause

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Objective This study aimed to examine the association between neighborhood poverty and ovarian reserve. Methods Among 1,019 healthy premenopausal women in the Ovarian Aging Study, aggregate exposure to neighborhood poverty was examined in relation to biomarkers of ovarian reserve, antimüllerian hormone (AMH) and antral follicle count (AFC). Specifically, the interaction of age-x-neighborhood poverty was assessed cross-sectionally to determine whether AMH and AFC declines across women may be greater in women exposed to more neighborhood poverty. Neighborhood poverty was assessed by geocoding and linking women's residential addresses in adulthood to US Census data. Results Independent of covariates, a significant interaction term showed the association between age and AMH varied by degree of exposure to neighborhood poverty in adulthood (b = −0.001, P < 0.05). AMH declines increased progressively across women exposed to low, medium, and high levels of neighborhood poverty. In addition, main effects showed that higher neighborhood poverty was related to higher AMH in the younger women only (b = 0.022, P < 0.01). Results related to AFC were all nonsignificant (P > 0.05). Conclusions Across women, greater aggregate exposure to neighborhood poverty in adulthood was related to lower ovarian reserve, indexed by AMH. In addition, there was a positive association between neighborhood poverty and AMH in younger women that attenuated in the older women. Together, results suggest that neighborhood disadvantage may have detrimental impacts that manifest as initially higher AMH, resulting in greater ovarian follicle loss over time. However, it remains unclear whether these results examining differences across women may replicate when AMH declines by neighborhood poverty are examined longitudinally.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 63%

Association between neighborhood poverty and ovarian reserve: the ovarian aging study

Pan,

Crowder,

Cedars

et al. 2024

Menopause

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“…Higher iron concentration, transferrin saturation, and ferritin concentration were found in the PF of endometriosis patients than in the control group (59 and 49 mg mL −1 , respectively) [ 34 ]. Fe was found in the follicular fluid (FF) in women with diminished ovarian reserves (DOR, 1.56 mg L −1 ) and in healthy controls (1.50 mg L −1 ) [ 35 ]. In this work, we found that Fe was present in 100% of the PF samples, with a mean value of 3118 ± 5123 µg L −1 ( Table 7 ), which was significantly below those reported in the literature [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…In this work, we found that Fe was present in 100% of the PF samples, with a mean value of 3118 ± 5123 µg L −1 ( Table 7 ), which was significantly below those reported in the literature [ 34 ]. Conversely, the content of Fe in PF was higher as compared to FF [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…The median total blood concentration of Ti in the case group was significantly higher than in the control group (134 vs. 129 μg L −1 ) [ 46 ]. In FF, Ti was found to be significantly higher in healthy controls (179.06 μg L −1 ) compared to women with DOR (149.78 μg L −1 ) [ 35 ]. For PF samples, we found that Ti was present in 100% of the samples, with a mean concentration of 64.3 ± 68.9 μg L −1 ( Table 6 ), which is different from the concentrations found in total blood and FF [ 35 , 46 ].…”

Section: Resultsmentioning

confidence: 99%

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A New Advanced and Validated Method for the Determination of Potentially Toxic Metals and Trace and Ultra-Trace Elements in Peritoneal Fluid to Assess the Health Risks of Women with Gynecological Pathologies

López-Botella

Sánchez

Todolı́

et al. 2023

Toxics

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Toxic metals found in the environment have been linked to female infertility and gynecological illnesses. Reliable analytical methods, such as inductively coupled plasma tandem mass spectrometry (ICP-MS/MS), are necessary to determine the elemental composition of biological samples. Currently, the multielemental profile of peritoneal fluid (PF) samples has not yet been established. Due to the complexity of the PF matrix, an ICP-MS/MS-based method has been optimized to mitigate matrix effects and spectral interferences. A dilution factor of 1:4 was the best option to mitigate matrix effects while keeping sensitivity at an appropriate level. A collision gas (He) was useful to lower the extent of spectral interferences for 56Fe, 52Cr, 63Cu, and 68Zn. An intermediate validation test was performed to evaluate accuracy, achieving recoveries ranging from 90 to 110%. The method was validated in terms of intermediate precision, reproducibility, and trueness, with an expanded uncertainty lower than 15%. Afterward, it was applied to perform the multielemental analysis of 20 PF samples. The concentrations for major analytes were up to 151 µg L−1. Meanwhile,209Bi, 111Cd, 52Cr, 55Mn, 95Mo, 60Ni, 208Pb, 118Sn, and 51V were present at concentrations included within the 1–10 µg L−1 range, while 59Co and 139La were found at concentrations below 1 µg L−1.

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Biomarker and Arsenic

Saini,

Kumar,

Kumar

2023

Environmental Science and Engineering

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Arsenic exposure diminishes ovarian follicular reserve and induces abnormal steroidogenesis by DNA methylation

Cited by 26 publications

References 48 publications

Association between neighborhood poverty and ovarian reserve: the ovarian aging study

Association between neighborhood poverty and ovarian reserve: the ovarian aging study

A New Advanced and Validated Method for the Determination of Potentially Toxic Metals and Trace and Ultra-Trace Elements in Peritoneal Fluid to Assess the Health Risks of Women with Gynecological Pathologies

Biomarker and Arsenic

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