Arsenic exposure and tobacco consumption: Biomarkers and risk assessment

Marano, Kristin M.; Naufal, Ziad; Kathman, Steven J.; Bodnar, Joy A.; Borgerding, Michael F.; Wilson, Christopher C.

doi:10.1016/j.yrtph.2012.07.007

Cited by 15 publications

(14 citation statements)

References 28 publications

(27 reference statements)

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“…Exposure to As causes different types of cancers (head & neck, bladder, lung, skin, kidney, prostate, and liver) as well as cardiovascular disease, diabetes, developmental and reproductive effects [53][54][55][56]. It was suggested by Marano et al and Cox that due to potential mechanisms of As carcinogenicity, its removal from cigarette tobacco might reduce human health risks [57,58]. Epidemiology studies were reviewed, As biomarker concentrations in a population representative of the US were evaluated, and a probabilistic risk assessment was undertaken [59,60].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Arsenic Levels in Smokeless Tobacco Products and Biological Samples of Oral Cancer Patients and Control Consumers

Arain

Kazi

Afridi

et al. 2015

Biol Trace Elem Res

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It has been extensively reported that chewing of smokeless tobacco (SLT) can lead to cancers of oral cavity. In present study, the relationship between arsenic (As) exposure via chewing/inhaling different SLT products in oral cancer patients have or/not consumed SLT products was studied. The As in different types of SLT products (gutkha, mainpuri, and snuff) and biological (scalp hair and blood) samples of different types of oral cancer patients and controls were analyzed. Both controls and oral cancer patients have same age group (ranged 30-60 years), socio-economic status, localities, and dietary habits. The concentrations of As in SLT products and biological samples were measured by electrothermal atomic absorption spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked by certified reference materials. The resulted data of present study indicates that the concentration of As was significantly higher in scalp hair and blood samples of oral cancer patients than those of controls (p<0.001). It was also observed that the values of As were two- to threefolds higher in biological samples of controls subjects, consuming SLT products as compared to those have none of these habits (p>0.01). The intake of As via consuming different SLT may have synergistic effects, in addition to other risk factors associated with oral cancer.

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Section: Discussionmentioning

confidence: 99%

Correlation of Arsenic Levels in Smokeless Tobacco Products and Biological Samples of Oral Cancer Patients and Control Consumers

Arain

Kazi

Afridi

et al. 2015

Biol Trace Elem Res

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“…The body burden of cadmium was assessed as being approximately two-fold higher in smokers than in non-smokers [18] , [7] , [19] . The impact of smoking on the lead body burden is observed through a sequestration in bones [20] , [21] , [22] , but not in blood [23] , [24] , while no effect from smoking could be observed in the case of arsenic [25] , or mercury [26] , [27] . Surveys also showed that smoking is not an important source for nickel [28] .…”

Section: Introductionmentioning

confidence: 93%

Differences in cadmium transfer from tobacco to cigarette smoke, compared to arsenic or lead

et al. 2015

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HighlightsArsenic, cadmium and lead levels in tobacco and smoke from a worldwide sample of 568 cigarettes are presented and discussed.Enhanced retention of cadmium, but not lead, was observed in cigarettes with carbon filters compared to the other cigarettes.Differences in speciation between cadmium, arsenic and lead were related to their distribution in ash, butt and smoke streams.The transient formation of organometallic derivatives could adequately explain the observed cadmium selective filtration.

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“…Because the use of arsenic-containing pesticides has declined, smoking no longer appears to represent a major exposure pathway for As [19]. Human toxicity of As is made complex by its multiple valence states and this has not yet been satisfactorily characterized in tobacco smoke, although it is known that As exists in mainstream smoke dominantly in its more toxic inorganic forms [20], making it a noteworthy element to examine.…”

Section: Introductionmentioning

confidence: 99%

Toxic Metal Concentrations in Cigarettes Obtained from U.S. Smokers in 2009: Results from the International Tobacco Control (ITC) United States Survey Cohort

Caruso

O’Connor

Stephens

et al. 2013

IJERPH

107

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Smoking-related diseases can be attributed to the inhalation of many different toxins, including heavy metals, which have a host of detrimental health effects. The current study reports the levels of arsenic (As), cadmium (Cd), chromium (Cr), nickel (Ni), and lead (Pb) in cigarettes obtained from adult smokers participating in the 2009 wave of the ITC United States Survey (N = 320). The mean As, Cd, Cr, Ni, and Pb levels were 0.17, 0.86, 2.35, 2.21, and 0.44 µg/g, respectively. There were some differences in metal concentrations of cigarette brands produced by different manufacturers, suggesting differences in the source of tobaccos used by different companies. For Ni, there were significant pairwise differences between Philip Morris U.S. (PMUSA) and R.J. Reynolds (RJR) brands (PMUSA higher; p < 0.001), PMUSA and other manufacturer (OM) brands (PMUSA higher; p < 0.001), and RJR and OM brands (RJR higher; p = 0.006). For Cr, RJR brands had higher levels than did OM brands (p = 0.02). Levels of As, Cd, and Pb did OPEN ACCESS Int. J. Environ. Res. Public Health 2014, 11203 not differ significantly across manufacturer groups (p > 0.10). Because of the variety of toxic heavy metals in cigarette tobacco, and their numerous negative health effects, metal content in cigarette tobacco should be reduced.

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Arsenic exposure and tobacco consumption: Biomarkers and risk assessment

Cited by 15 publications

References 28 publications

Correlation of Arsenic Levels in Smokeless Tobacco Products and Biological Samples of Oral Cancer Patients and Control Consumers

Correlation of Arsenic Levels in Smokeless Tobacco Products and Biological Samples of Oral Cancer Patients and Control Consumers

Differences in cadmium transfer from tobacco to cigarette smoke, compared to arsenic or lead

Toxic Metal Concentrations in Cigarettes Obtained from U.S. Smokers in 2009: Results from the International Tobacco Control (ITC) United States Survey Cohort

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