Arsenic exposure and biomarkers for oxidative stress and telomere length in indigenous populations in Bolivia

Loma, Jessica De; Krais, Annette M.; Lindh, Christian; Mamani, Josue; Tirado, Noemí; Gardon, Jacques; Broberg, Karin

doi:10.1016/j.ecoenv.2022.113194

Cited by 9 publications

(13 citation statements)

References 46 publications

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“…A couple of human population studies showed that the higher the arsenic exposure, the longer the telomere length ( Table 1 ) ( 31 , 32 , 50 , 52 , 54 , 55 ). For instance, a study conducted among Argentinian women supported the dose-related association ( 55 ).…”

Section: Arsenic Exposure and Telomere Lengthmentioning

confidence: 99%

“…Meanwhile, the results are consistent in Bangladesh adults, where the mean arsenic concentration was about half of the above studies at 188 μg/L ( 32 ). In Bolivian women, the exposure dose was as low as 88 μg/L ( 50 ). Even though most exposure values are higher than those in younger populations, it is noteworthy that arsenic-induced telomere lengthening is prevalent in adulthood, thereby calling for further research on other possible contributing factors such as genetic polymorphism, occupation, living environment, and other stresses.…”

Section: Considerations For the Effects Of Arsenic On Telomere Lengthmentioning

confidence: 99%

“…Another point to be considered is the toxicity of the metabolites of arsenic. Even among inorganic forms of arsenic, arsenite (AsIII) is considered more toxic than arsenate (AsV), which is methylated by a specific enzyme, arsenite methyltransferase (AS3MT), to form end products monomethylarsinic acid (MMA), and dimethylarsinic acid (DMA) ( 50 , 64 ). The relative fractions of MMA and DMA, which are produced as a result of a series of reduction and methylation reactions of inorganic arsenic, represent the effectiveness of arsenic metabolism ( 65 ).…”

Section: Considerations For the Effects Of Arsenic On Telomere Lengthmentioning

confidence: 99%

“…Similarly, in the study among Bolivians, the data from 193 recruited females reflected the correlation of arsenic exposure to telomere length as a biomarker of arsenic toxicity (50). The study also claimed that there is no gender difference in the associations between arsenic and telomere length (50). Meanwhile, there are some inconsistencies while the speciation analysis of arsenic is considered.…”

Section: Introductionmentioning

confidence: 97%

“…The study involved 188 Mexican males: 78 subjects with urine arsenic levels of 11.2-17.4 µg/L as an exposed group and 112 with lower concentrations as a control group (52). Similarly, in the study among Bolivians, the data from 193 recruited females reflected the correlation of arsenic exposure to telomere length as a biomarker of arsenic toxicity (50). The study also claimed that there is no gender difference in the associations between arsenic and telomere length (50).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?

Wai

Swe

Myar

et al. 2023

Front. Public Health

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Maintaining telomere length plays a crucial role in regulating cellular life span. Telomere lengthening or shortening is one of the important biomarkers which could predict the preceding or present diseases. Meanwhile, the impact of environmental arsenic exposure on telomere length has increasingly concerned. Although previous studies demonstrated the effects of arsenic on telomere length, the findings were unclear on whether telomere shortens or lengthens by arsenic exposure. Thus, this manuscript summarized and discussed the telomere length alteration following arsenic exposure and the possible does-response effect of arsenic on telomere length. The present review suggested that different age groups may respond differently to arsenic exposure, and the dose-response effect of arsenic could be a critical factor in its effect on telomere length. Moreover, speciation analysis of arsenic could be more informative in identifying the effect of arsenic on telomere length.

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Section: Arsenic Exposure and Telomere Lengthmentioning

confidence: 99%

Section: Considerations For the Effects Of Arsenic On Telomere Lengthmentioning

confidence: 99%

Section: Considerations For the Effects Of Arsenic On Telomere Lengthmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?

Wai

Swe

Myar

et al. 2023

Front. Public Health

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Epigallocatechin‐3‐gallate attenuates arsenic‐induced fibrogenic changes in human kidney epithelial cells through reversal of epigenetic aberrations and antioxidant activities

Iheanacho,

Kandel,

Roy

et al. 2023

BioFactors

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Renal fibrosis is a pathogenic intermediate stage of chronic kidney disease (CKD). Nephrotoxicants including arsenic can cause kidney fibrosis through induction of oxidative stress and epigenetic aberrations. Epigallocatechin‐3‐gallate (EGCG), a green tea polyphenol, is known to have antioxidant and epigenetic modulation properties. Whether EGCG, through its antioxidant and epigenetic modulating activities, can attenuate fibrogenesis is not known. Therefore, the objective of this study was to determine whether EGCG can attenuate arsenic‐induced acute injury and long‐term exposure associated fibrogenicity in kidney epithelial cells. To address this question, two human kidney epithelial cell lines Caki‐1 and HK‐2 exposed to arsenic for both acute and long‐term durations were treated with EGCG. The protective effect of EGCG on arsenic‐induced cytotoxicity and fibrogenicity were evaluated by measuring the cell growth, reactive oxygen species (ROS) production, genes expression, and epigenetic changes in histone marks. Results revealed that EGCG has a protective effect in arsenic‐induced acute cytotoxicity in these cells. EGCG scavenges the increased levels of ROS in arsenic exposed cells. Aberrant expression of fibrogenic genes in arsenic exposed cells were restored by EGCG. Abrogation of arsenic‐induced fibrogenic changes was also associated with EGCG‐mediated restoration of arsenic‐induced aberrant expression of epigenetic regulatory proteins and histone marks. Novel findings of this study suggest that EGCG, through its antioxidant and epigenetic modulation capacities, has protective effects against arsenic‐induced cytotoxicity and fibrogenic changes in kidney epithelial cells.

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Genotoxicity in humans exposed to arsenic, lithium, and boron in drinking water in the Bolivian Andes—A cross sectional study

Tirado,

Mamani,

De Loma

et al. 2024

Environ and Mol Mutagen

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Elevated concentrations of arsenic, lithium and boron in drinking water have already been reported in Bolivia. Arsenic is known to cause genotoxicity but that caused by lithium and boron is less well known. The aim of the present cross‐sectional study was to evaluate potential genotoxic effects of exposure to arsenic, while considering exposure to lithium and boron and genetic susceptibility. Women (n = 230) were recruited in villages located around Lake Poopó. Exposure to arsenic was determined as the sum of concentrations of arsenic metabolites inorganic arsenic, monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) in urine. Exposure to lithium and boron was determined based on their concentrations in urine. Genetic susceptibility was determined by GSTM1 (glutathione S‐transferase‐mu‐1) and GSTT1 (glutathione S‐transferase‐theta‐1) null genotypes and AS3MT (Arsenite Methyltransferase) rs3740393. Genotoxicity was measured in peripheral blood leukocytes using the comet assay. The geometric means of arsenic, lithium, and boron concentrations were 68, 897, and 3972 μg/L, respectively. GSTM1 and GSTT1 null carriers had more DNA strand breaks than gene carriers (p = .008, p = .005). We found no correlation between urinary arsenic and DNA strand breaks (rS = .03, p = .64), and only a weak non‐significant positive association in the adjusted multivariate analysis (β = .09 [−.03; .22], p = .14). Surprisingly, increasing concentrations of lithium in urine were negatively correlated with DNA strand breaks (rS = −.24, p = .0006), and the association persisted in multivariate analysis after adjusting for arsenic (β = −.22 [−.36; −.08], p = .003). We found no association between boron and DNA strand breaks. The apparent protective effect of lithium merits further investigation.

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Arsenic exposure and biomarkers for oxidative stress and telomere length in indigenous populations in Bolivia

Cited by 9 publications

References 46 publications

Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?

Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?

Epigallocatechin‐3‐gallate attenuates arsenic‐induced fibrogenic changes in human kidney epithelial cells through reversal of epigenetic aberrations and antioxidant activities

Genotoxicity in humans exposed to arsenic, lithium, and boron in drinking water in the Bolivian Andes—A cross sectional study

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