Arsenic exposure alters lung function and airway inflammation in children: A cohort study in rural Bangladesh

Ahmed, Sultan; Akhtar, Evana; Roy, Adity; Ehrenstein, Ondine S. von; Vahter, Marie; Wagatsuma, Yukiko; Raqib, Rubhana

doi:10.1016/j.envint.2017.01.014

Cited by 62 publications

(33 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Participants ranged from 7 to 65 years of age and included both men and women, except one study that only included men. 20 By study design, there were two prospective cohort studies 11,25 three retrospective studies, 12,22,24 which reconstructed early life arsenic exposure from historical measures of water arsenic, and four cross-sectional studies. 13,20,21,30 Studies were characterized by a wide range of arsenic exposure, although in most studies the majority of the arsenic-exposed population was exposed to water arsenic levels above 100 μg/L.…”

Section: Resultsmentioning

confidence: 99%

“…11,24 Three studies included exposure based on participants’ total urinary arsenic levels. 11,13,25 One used maternal urinary arsenic levels during gestation as a proxy for in utero exposure and lung function among children 9 years of age. 25 For the study outcomes, nine studies reported FEV 1 and FVC.…”

Section: Resultsmentioning

confidence: 99%

“…11,13,25 One used maternal urinary arsenic levels during gestation as a proxy for in utero exposure and lung function among children 9 years of age. 25 For the study outcomes, nine studies reported FEV 1 and FVC. Three studies also reported measures of association between arsenic and FEV 1 /FVC.…”

Section: Resultsmentioning

confidence: 99%

“…Several studies reported measures of association on arsenic and lung function (FEV 1 and FVC only) stratified by sex 11,12,21,25 or smoking status. 11,12,21,22 Half of the studies also examined early life exposure 12,13,22,24,25 (Supplementary Material).…”

Section: Resultsmentioning

confidence: 99%

“…Although most of the included studies used water arsenic as their main marker of exposure, two studies only had urinary arsenic 13,25 and another study reported measures of association for both. 11 To confirm results using water arsenic or urine arsenic were generally consistent with one another, we stratified studies by exposure measure (water and urine).…”

Section: Methodsmentioning

confidence: 99%

See 4 more Smart Citations

A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease?

Sanchez

Powers

Perzanowski

et al. 2018

Curr Envir Health Rpt

View full text Add to dashboard Cite

Purpose of review: Hundreds of millions of people worldwide are exposed to arsenic via contaminated water. The goal of this study was to identify whether arsenic-associated lung function deficits resemble obstructive- or restrictive-like lung disease, in order to help illuminate a mechanistic pathway and identify at-risk populations. Recent findings: We recently published a qualitative systematic review outlining the body of research on arsenic and non-malignant respiratory outcomes. Evidence from several populations, at different life stages, and at different levels of exposure showed consistent associations of arsenic exposure with chronic lung disease mortality, respiratory symptoms, and lower lung function levels. The published review, however, only conducted a broad qualitative description of the published studies without considering specific spirometry patterns, without conducting a meta-analysis, and without evaluating the dose-response relationship. Summary: We searched PubMed and Embase for studies on environmental arsenic exposure and lung function. We performed a meta-analysis using inverse-variance weighted random-effects models to summarize adjusted effect estimates for arsenic and forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio. Across nine studies, median water arsenic levels ranged from 23 to 860 μg/L. The pooled estimated mean difference (MD) comparing the highest category of arsenic exposure (ranging from >11 to >800 μg/L) versus the lowest (ranging from <10 to <100 μg/L) for each study for FEV1 was −42 (95% confidence interval (CI): −70, −16) mL and for FVC was −50 (95%CI: −63, −37) mL. Three studies reported effect estimates for FEV1/FVC, for which there was no evidence of an association; the pooled estimated MD was 0.01 (95%CI: −0.005, 0.024). This review supports that arsenic is associated with restrictive impairments based on inverse associations between arsenic and FEV1 and FVC, but not with FEV1/FVC. Future studies should confirm whether low-level arsenic exposure is a restrictive lung disease risk factor in order to identify at-risk populations in the US.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease?

Sanchez

Powers

Perzanowski

et al. 2018

Curr Envir Health Rpt

View full text Add to dashboard Cite

show abstract

Arsenic Contamination of India’s Groundwater: A Review and Critical Analysis

Dhillon

2019

Advances in Water Security

View full text Add to dashboard Cite

Gestational exposure to inorganic arsenic (iAs3+) alters glutamate disposition in the mouse hippocampus and ionotropic glutamate receptor expression leading to memory impairment

et al. 2017

View full text Add to dashboard Cite

Early life exposure to environmental pollutants and toxic chemicals has been linked to learning and behavioral alterations in children. iAs exposure is associated with different types neurological disorders such as memory and learning impairment. iAs is methylated in the brain by the arsenic III-methyltransferase in a process that requires glutathione (GSH). The xCT-antiporter cell membrane transporter participates in the influx of cystine for GSH synthesis in exchange for glutamate in a 1:1 ratio. In CD-1 mice gestationally exposed to 20 ppm of sodium arsenite in drinking water, we have previously observed up-regulation of xCT in the male mouse hippocampus which caused glutamatergic synapse alterations affecting learning and memory processes. Here, we used the same gestational iAs exposure model to investigate whether the up-regulation of xCT and down-regulation of GLT-1 transporters were associated with higher levels of extracellular glutamate and changes in the expression of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor, responsible for excitatory fast synaptic transmission. The induction of LTP in the perforant-dentate gyrus pathway (PP-DG) of the hippocampus was also studied, as well as learning and memory formation using the water maze test. Changes in GSH levels were also tested in the hippocampus of animals exposed to iAs. Results showed increased GSH synthesis (p < 0.05), associated with significantly higher extracellular glutamate levels in iAs exposed mice. Exposure was also significantly associated with AMPA subunits down-regulation, deficient LTP induction, and lower excitability of the PP-DG pathway. In addition, animals showed deficient learning and memory in the Morris Water Maze test.

show abstract

Arsenic exposure alters lung function and airway inflammation in children: A cohort study in rural Bangladesh

Cited by 62 publications

References 51 publications

A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease?

A Meta-analysis of Arsenic Exposure and Lung Function: Is There Evidence of Restrictive or Obstructive Lung Disease?

Arsenic Contamination of India’s Groundwater: A Review and Critical Analysis

Gestational exposure to inorganic arsenic (iAs3+) alters glutamate disposition in the mouse hippocampus and ionotropic glutamate receptor expression leading to memory impairment

Contact Info

Product

Resources

About