Arsenic exposure: A public health problem leading to several cancers

Palma‐Lara, Icela; Martínez-Castillo, Macario; Quintana-Pérez, Julio César; Arellano-Mendoza, Mónica Griselda; Tamay‐Cach, Feliciano; Valenzuela, Olga L.; García-Montalvo, Eliud A.; Hernández-Zavala, Araceli

doi:10.1016/j.yrtph.2019.104539

Cited by 298 publications

(130 citation statements)

References 110 publications

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“…According to the IACR, aArsenic has been implicated in cancers of the skin, lungs, bladder, prostate, kidneys, and liver in humans [63,64]. Arsenic has also been implicated in the development of vascular disease, including stroke and ischaemic heart disease [65]. Recent studies have also suggested diabetic, neurological, and reproductive sequelae [66].…”

Section: Arsenicmentioning

confidence: 99%

Epidemiology of lung cancer

Thandra¹,

Barsouk²,

Saginala³

et al. 2021

317

153

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Lung cancer is the leading cause of global cancer incidence and mortality, accounting for an estimated 2 million diagnoses and 1.8 million deaths. Neoplasms of the lungs are the second most common cancer diagnosis in men and women (after prostate and breast cancer, respectively). With increasing access to tobacco and industrialization in developing nations, lung cancer incidence is rising globally. The average age of diagnosis is 70 years old. Men are twice as likely to be diagnosed with lung cancer, which largely reflects differences in tobacco consumption, although women may be more susceptible due to higher proportions of epidermal growth factor receptor mutations and the effects of oestrogen. African American men in the US are at the highest risk of lung cancer. Family history increases risk by 1.7-fold, with a greater risk among first-degree relatives. Tobacco smoking is the greatest preventable cause of death worldwide, accounting for up to 90% of lung cancer cases, and continued consumption is projected to increase global cancer incidence, particularly in developing nations such as China, Russia, and India. Second-hand smoke among children and spouses has likewise been implicated. Radon from natural underground uranium decay is the second leading cause of lung cancer in the developed world. Occupational hazards such as asbestos and environmental exposures such as air pollution, arsenic, and HIV and Tb infection have all been implicated in lung carcinogenesis, while cannabis smoking, electronic cigarettes, heated tobacco products, and COVID-19 have been hypothesized to increase risk.

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Section: Arsenicmentioning

confidence: 99%

Epidemiology of lung cancer

Thandra¹,

Barsouk²,

Saginala³

et al. 2021

317

153

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“…As has also been implicated in the development of vascular disease, including stroke and ischemic heart disease. 44 Recent studies have also suggested diabetic, neurological, and reproductive sequela. 45 Animal and cell model systems have demonstrated carcinogenesis promoted by Arsenic, while epidemiological studies have shown an association between exposure and a spectrum of hepatic disorders, including hepatomegaly, sclerosis, fibrosis, cirrhosis, and liver cancer.…”

Section: Arsenicmentioning

confidence: 99%

Chemical Risk Factors of Primary Liver Cancer: An Update

Barsouk¹,

Thandra²,

Saginala³

et al. 2021

HMER

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“…Arsenic (As) is a carcinogenic metalloid found widely in the environment (Clemens & Ma, 2016; Cooper et al, 2020). Arsenic toxicity decreases crop yields, and accumulation of arsenic in edible crop tissues can cause contamination of the food chain and lead to severe human health problems (Clemens, 2019; Rai, Lee, Zhang, Tsang, & Kim, 2019;Abedi & Mojiri, 2020; Palma-Lara et al, 2020). For example, rice grain can accumulate up to 2.24 mg/kg As and has become a dominant dietary exposure route to arsenic (As) (Gilbert-Diamond et al, 2011; Pan, Wu, Xue, & Hartley, 2014).…”

Section: Introductionmentioning

confidence: 99%

An amiRNA screen uncovers redundant CBF & ERF34/35 transcription factors that differentially regulate arsenite and cadmium responses

Xie

Jobe

et al. 2021

Preprint

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Arsenic stress causes rapid transcriptional responses in plants. However, transcriptional regulators of arsenic-induced gene expression in plants remain less well known. To date, forward genetic screens have proven limited for dissecting arsenic response mechanisms. We hypothesized that this may be due to the extensive genetic redundancy present in plant genomes. To overcome this limitation, we pursued a forward genetics screen for arsenite tolerance using a randomized library of plants expressing >2,000 artificial microRNAs (amiRNAs). This library was designed to knock-down diverse combinations of homologous gene family members within sub-clades of transcription factor and transporter gene families. We identified six transformant lines showing an altered response to arsenite in root growth assays. Further characterization of an amiRNA line targeting closely homologous CBF and ERF transcription factors show that the CBF1,2 and 3 transcription factors negatively regulate arsenite sensitivity. Furthermore, the ERF34 and ERF35 transcription factors are required for cadmium resistance. Generation of CRISPR lines, higher-order T-DNA mutants, and gene expression analyses, further support our findings. These ERF transcription factors differentially regulate arsenite sensitivity and cadmium tolerance.

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Arsenic exposure: A public health problem leading to several cancers

Cited by 298 publications

References 110 publications

Epidemiology of lung cancer

Epidemiology of lung cancer

Chemical Risk Factors of Primary Liver Cancer: An Update

An amiRNA screen uncovers redundant CBF & ERF34/35 transcription factors that differentially regulate arsenite and cadmium responses

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