Arsenic drinking water exposure and urinary excretion among adults in the Yaqui Valley, Sonora, Mexico

Meza, Mercedes; Kopplin, Michael J.; Burgess, Jefferey L.; Gandolfi, A. Jay

doi:10.1016/j.envres.2003.08.010

Cited by 90 publications

(53 citation statements)

References 23 publications

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“…When treating drinking water intake as a continuous variable (within Metrics 2 and 3 as l per day Â mg/l), the exposure metric did not improve the ability to predict urinary arsenic. A previous attempt to predict urinary arsenic output in a population exposed to slightly higher levels of arsenic in drinking water (arsenic in water ranged from 5.5 to 43.3 mg/ l), an increase in water consumption, treated as a continuous variable, resulted in an increase in SumAs (Meza et al, 2004). It is unclear why our study population did not show improved correlation when treating drinking water as a continuous variable.…”

Section: Discussionmentioning

confidence: 65%

“…In addition to arsenic concentration alone, available evidence suggests that volume of water intake may be an influential modifier of ingestion exposures (Wright et al, 2006). A study conducted in Mexico where the population was exposed to arsenic in drinking water between 3.3 and 49.3 mg/l showed that considering total arsenic intake per day influenced the correlation between arsenic concentrations in water and urinary arsenic (Meza et al, 2004). The correlation coefficient improved from 0.35 (P ¼ 0.02) to 0.50 (Po0.0001) when the volume of water intake was included in the exposure metric.…”

Section: Introductionmentioning

confidence: 99%

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Urinary arsenic species, toenail arsenic, and arsenic intake estimates in a Michigan population with low levels of arsenic in drinking water

Rivera‐Núñez

Meliker

Meeker

et al. 2011

J Expo Sci Environ Epidemiol

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The large disparity between arsenic concentrations in drinking water and urine remains unexplained. This study aims to evaluate predictors of urinary arsenic in a population exposed to low concentrations (r50 mg/l) of arsenic in drinking water. Urine and drinking water samples were collected from a subsample (n ¼ 343) of a population enrolled in a bladder cancer case-control study in southeastern Michigan. Total arsenic in water and arsenic species in urine were determined using ICP-MS: arsenobetaine (AsB), arsenite ( A separate analysis indicated that AsB and DMA [V] were significantly correlated with fish and shellfish consumption, which may suggest that seafood intake influences DMA[V] excretion. The Spearman correlation between arsenic concentration in toenails and SumAs was 0.36 and between arsenic concentration in toenails and arsenic concentration in water was 0.42. Results show that arsenic exposure from drinking water consumption is an important determinant of urinary arsenic concentrations, even in a population exposed to relatively low levels of arsenic in drinking water, and suggest that seafood intake may influence urinary DMA [V] concentrations.

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Section: Discussionmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Urinary arsenic species, toenail arsenic, and arsenic intake estimates in a Michigan population with low levels of arsenic in drinking water

Rivera‐Núñez

Meliker

Meeker

et al. 2011

J Expo Sci Environ Epidemiol

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“…In the German Environmental Survey III of 1998, median urinary total arsenic levels in 4052 adults varied with seafood intake and were approximately two-fold lower than those for NHANES 2003(Schulz et al, 2007. Higher mean or median (Calderon et al, 1999;Meza et al, 2004;Valenzuela et al, 2005;Josyula et al, 2006;Rubin et al, 2007), as well as for other areas of the world (Ahsan et al, 2000;Aposhian et al, 2000;Caceres et al, 2005;Sun et al, 2007), that were known to have higher levels of arsenic in their drinking water. Median and mean total urinary arsenic levels for residents in some districts in Bangladesh have been reported to be about 50-fold higher than the respective levels in NHANES 2003(Ahsan et al, 2000Chowdhury et al, 2003) and geometric mean levels were about 70-fold higher for residents of Inner Mongolia, China (Sun et al, 2007).…”

Section: Discussionmentioning

confidence: 97%

Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004

Caldwell

Jones

Verdon

et al. 2008

J Expo Sci Environ Epidemiol

171

110

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Objective: To provide levels of total and speciated urinary arsenic in a representative sample of the US population. Methods: For the first time, total arsenic and seven inorganic and organic arsenic species were measured in the urine of participants (n ¼ 2557) for the [2003][2004] National Health and Nutrition Examination Survey (NHANES). Data were compiled as geometric means and selected percentiles of urinary arsenic concentrations (mg/l) and creatinine-corrected urinary arsenic (mg/g creatinine) for total arsenic, dimethylarsinic acid, arsenobetaine, and a sum of the inorganic related species. Results: Arsenic acid, arsenous acid, arsenocholine, and trimethylarsine oxide were detected in 7.6%, 4.6%, 1.8%, and 0.3% of the participants, respectively (the limits of detection of 0.6-1.2 mg/l). Monomethylarsonic acid was detected in 35% of the overall population. For all participants aged Z6 years, dimethylarsinic acid (geometric mean of 3.71 mg/l) and arsenobetaine (geometric mean of 1.55 mg/l) had the greatest contribution to the total urinary arsenic levels. A relatively greater percentage contribution from arsenobetaine is seen at higher total urinary arsenic levels and from dimethylarsinic acid at lower total urinary arsenic levels. For all participants aged Z6 years, the 95th percentiles for total urinary arsenic and the sum of inorganic-related arsenic (arsenic acid, arsenous acid, dimethylarsinic acid, and monomethylarsonic acid) were 65.4 and 18.9 mg/l, respectively. For total arsenic and dimethylarsinic acid, covariate-adjusted geometric means demonstrated several slight differences due to age, gender, and race/ethnicity. Conclusions: The data reflect relative background contributions of inorganic and seafood-related arsenic exposures in the US population. Arsenobetaine and dimethylarsinic acid are the major arsenic species present with arsenobetaine, accounting for a greater proportion of total arsenic as total arsenic levels increase. Keywords: speciated arsenic, human, urine, biomonitoring, NHANES. IntroductionArsenic is an element that is widely distributed in the earth's surface in small amounts, primarily in its inorganic forms. Anthropomorphic sources of arsenic have included the smelting of mined metals. Inorganic arsenic is used currently as an outdoor wood preservative, in some pesticides, as semiconductor dopant materials, and in certain medicines. General human exposure to inorganic arsenic results from natural amounts consumed in drinking water. However, dietary arsenic may be an important source (NRC, 2001) when drinking water levels are low. Arsenic also forms organic compounds through biological action on inorganic arsenic. These organic forms are found in fish, shellfish, seaweed, and aquatic sediments and are generally much less toxic. These dietary arsenic species are commonly represented by arsenobetaine and, to a lesser extent, by arsenocholine and arsenosugars (Heinrich-Ramm et al., 2002). In addition to the arsenical forms found in marine organisms, mono-and dimethylated pentava...

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“…Speciation analysis of urinary arsenic has been conducted among populations who drink arsenic-polluted water [14][15][16]; however, the relationships between each urinary arsenic species are not reported. To accurately determine the proportions of urinary arsenic metabolites of individuals continuously exposed to iAs, we performed arsenic speciation analysis of the urine of residents drinking iAs-contaminated water who do not ingest organic arsenic from seafood.…”

Section: Introductionmentioning

confidence: 99%

Arsenic speciation analysis of urine samples from individuals living in an arsenic-contaminated area in Bangladesh

Hata

Yamanaka

Habib

et al. 2011

Environ Health Prev Med

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Objectives Chronic inorganic arsenic (iAs) exposure currently affects tens of millions of people worldwide. To accurately determine the proportion of urinary arsenic metabolites in residents continuously exposed to iAs, we performed arsenic speciation analysis of the urine of these individuals and determined whether a correlation exists between the concentration of iAs in drinking water and the urinary arsenic species content. Methods The subjects were 165 married couples who had lived in the Pabna District in Bangladesh for more than 5 years. Arsenic species were measured using high-performance liquid chromatography and inductively coupled plasma mass spectrometry. Results The median iAs concentration in drinking water was 55 lgAs/L (range \0.5-332 lgAs/L). Speciation analysis revealed the presence of arsenite, arsenate, monomethylarsonic acid (MMA), and dimethylarsinic acid in urine samples with medians (range) of 16.8 (7.7-32.3), 1.8 (\0.5-3.3), 13.7 (5.6-25.0), and 88.6 lgAs/L (47.9-153.4 lgAs/L), respectively. No arsenobetaine or arsenocholine was detected. The concentrations of the 4 urinary arsenic species were significantly and linearly related to each other. The urinary concentrations of total arsenic and each species were significantly correlated with the iAs concentration of drinking water. Conclusions All urinary arsenic species are well correlated with each other and with iAs in drinking water. The most significant linear relationship existed between the iAs concentration in drinking water and urinary iAs ? MMA concentration. From these results, combined with the effects of seafood ingestion, the best biomarker of iAs exposure is urinary iAs ? MMA concentration.

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Arsenic drinking water exposure and urinary excretion among adults in the Yaqui Valley, Sonora, Mexico

Cited by 90 publications

References 23 publications

Urinary arsenic species, toenail arsenic, and arsenic intake estimates in a Michigan population with low levels of arsenic in drinking water

Urinary arsenic species, toenail arsenic, and arsenic intake estimates in a Michigan population with low levels of arsenic in drinking water

Levels of urinary total and speciated arsenic in the US population: National Health and Nutrition Examination Survey 2003–2004

Arsenic speciation analysis of urine samples from individuals living in an arsenic-contaminated area in Bangladesh

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