Arsenic disulfide promoted the demethylation of PTPL1 in diffuse large B cell lymphoma cells
Chen Chen,
Ling Wang,
Yan Liu
et al.
Abstract:Background
Promoter hypermethylation of the tumor suppressor gene is one of the well-studied causes of cancer development. The drugs that reverse the process by driving demethylation could be a candidate for anticancer therapy. This study was designed to investigate the effects of arsenic disulfide on PTPL1 methylation in diffuse large B cell lymphoma (DLBCL).
Methods
We knocked down the expression of PTPL1 in two DLBCL cell lines (i.e., DB… Show more
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