Arsenic decreases antinociceptive activity of paracetamol: Possible involvement of serotonergic and endocannabinoid receptors

Vijayakaran, Karunakaran; Kesavan, Manickam; Kandasamy, Kannan; Sankar, P.; Tandan, Surendra K.; Sarkar, Srobana

doi:10.1016/j.etap.2014.07.001

Cited by 10 publications

(7 citation statements)

References 41 publications

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“…5 Acetaminophen administration has also been shown to increase the serotonin levels in supraspinal structures and led to a down-regulation of 5-HT 2A receptor subtypes in the frontal cortex and brain stem. 14 In that study, the authors stated that an increase in serotonin release triggered by acetaminophen caused down-regulation of 5-HT 2A receptors related to the long duration of stimulus by serotonin. This assertion was supported by the study by Srikiatkhachorn et al 27 claiming that 5-HT 2A receptor down-regulation is important for the analgesic effect of acetaminophen.…”

Section: Role Of 5-ht 2 Receptorsmentioning

confidence: 98%

The Contribution of Serotonergic Receptors and Nitric Oxide Systems in the Analgesic Effect of Acetaminophen: An Overview of the Last Decade

Hamurtekin

Nouilati

Demirbatir

et al. 2020

tjps

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Yeşim HAMURTEKİN, Ammar NOUILATI, Cansu DEMİRBATIR, Emre HAMURTEKİN* Asetaminofen yaygın kullanılan analjezik ve antipiretik bir ajandır. Reçetesiz verilebilen formülasyonlarının da mevcudiyeti sık kullanımını artırmıştır. Günümüze kadar asetaminofenin analjezik etki mekanizmasını inceleyen bir çok çalışma bulunmaktadır. Santral sinir sisteminde siklooksijenaz yolağını inhibe etmesinin yanında, opioiderjik, kannabinoiderjik, dopaminerjik, kolinerjik ve nitrerjik sistemler kadar, bulbospinal serotonerjik yolaklar gibi analjezik etkili inen inhibitör yolakların da asetaminofenin analjezik etkisinde katkısı olan olası mekanizmalar olduğu önerilmiştir. Bu derlemede santral serotonerjik sistem ve santral sinir sistemindeki serotonerjik reseptör alt tiplerinin parasetamolün analjezik etkisine katkısını ortaya koyan verileri bir araya getirmeyi amaçladık. Bunu yaparken, esas olarak son on yılda yapılmış çalışmalara odaklandık ve önceki verilerle son eklenenler arasında bir bağlantı kurmaya çalıştık. Serotonerjik sistemin katkısına ek olarak, aynı zamanda son on yıldaki yeni bulgularla asetaminofenin ağrı kesici etkisinde nitrik oksidin rolünü de derledik. Anahtar kelimeler: Asetaminofen, serotonin, ağrı, nitrik oksit Acetaminophen is a widely used analgesic and antipyretic agent. It is also available in over the counter formulations, which has increased its wide use. There have been many studies to date that have aimed to evaluate the mechanism of the analgesic action of acetaminophen. Additional to the inhibition of the cyclooxygenase pathway in the central nervous system, the involvement of opioidergic, cannabinoidergic, dopaminergic, cholinergic, and nitrergic systems as well as the contribution of descending pain inhibitory systems like the bulbospinal serotonergic pathway has been proposed as possible mechanisms of the analgesic action of acetaminophen. In this review, we aimed to collect the data from studies revealing the contribution of the central serotonergic system and the role of central nervous system-located serotonergic receptor subtypes in the analgesic effect of acetaminophen. While doing this, we mainly focused on the research that has been performed in the last ten years and tried to link the previous data with the lately added results. In addition to serotonergic system involvement, we also reviewed the role of nitric oxide in the analgesic action of acetaminophen, especially with the new findings reported over the last decade.

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Section: Role Of 5-ht 2 Receptorsmentioning

confidence: 98%

The Contribution of Serotonergic Receptors and Nitric Oxide Systems in the Analgesic Effect of Acetaminophen: An Overview of the Last Decade

Hamurtekin

Nouilati

Demirbatir

et al. 2020

tjps

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“… Arsenic decreases activity of APAP. Involvement of 5-HT and CB receptors Formalin test Formalin Saline Rat/M Decreased behavior phase 1 400 Vijayakaran et al 2014 71 18. APAP involves spinal serotonin 5-HT7 and adenosine A1 receptors, and peripheral adenosine A1 receptors Formalin test Formalin Saline Mice/M Decreased behavior Phase 2 300 Liu et al 2013 120 19.…”

Section: Analgesic Efficacy Of Acetaminophen In Preclinical Modelsmentioning

confidence: 99%

“…Systemic acetaminophen typically results in a robust dose dependent suppression of phase II formalin and to a lesser degree phase I in mice (10–300 mg/kg) 73 (60) and rats (100–400 mg/kg) 82 but 71 IV acetaminophen shows analgesic effect in phase I only at high concentration (300 mg/kg) in rats. Phase II shows analgesic effects at doses of 100–300 mg/kg.…”

Section: Analgesic Efficacy Of Acetaminophen In Preclinical Modelsmentioning

confidence: 99%

Systematic Review of Systemic and Neuraxial Effects of Acetaminophen in Preclinical Models of Nociceptive Processing

Hoshijima¹,

Hunt²,

Nagasaka³

et al. 2021

JPR

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“…It was found that arsenic reduced paracetamol-induced analgesia possibly by interfering with pronociceptive 5-HT2A and antinociceptive CB1 receptors [19] . The effect of As on T cell population is mainly attributed to altered expression of key immune regulator molecules impaired T cell functions, cytokines production, induction of apoptosis, and oxidative stress induction in T cells [20] .…”

Section: A Few Examples To Substantiate Immunological Evidence Is Stated Herementioning

confidence: 99%

Arsenic and its effect on immunity: A narrative review

Bagdi¹

2021

Int. J. Homoeopathic Sci.

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Introduction: Human immune system has evolved through eons of struggle between the host and pathogens. Although Arsenic can act as immunostimulant by causing an elevation of inflammatory responses in our body, the immunosuppressive effects of Arsenic include modulation of the numbers, survival and functions of immune and hematopoietic cells and impaired humoral and cell-mediated immunity. Immunomodulation is a kind of regulatory modification in the immune system to bring the desired response. Homoeopathy embraces a holistic approach in curing diverse diseases and it is used globally as an alternative medicine and seeks to cure in harmony with natural laws of healing. The present review focusses on the collection of results of studies carried out on effect of arsenic on immunity. Methodology: In this review literature available from various published studies and databases like PubMed, Springer, Elsevier and AYUSH research portal and references from the relevant articles published literature were searched in English language up to December 2020. Results: 25 studies were included in this review of which 10 in vivo, 9 in vitro, 2 Ex vivo and 4 review articles. Most of the studies substantiate the definitive role of Arsenic on immunomodulation. Conclusion:In future extensive studies are required to further explore the immunomodulatory effects of homoeopathic medicines Arsenicum album and studies based on human-derived immune cells need more attention.

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Arsenic decreases antinociceptive activity of paracetamol: Possible involvement of serotonergic and endocannabinoid receptors

Cited by 10 publications

References 41 publications

The Contribution of Serotonergic Receptors and Nitric Oxide Systems in the Analgesic Effect of Acetaminophen: An Overview of the Last Decade

The Contribution of Serotonergic Receptors and Nitric Oxide Systems in the Analgesic Effect of Acetaminophen: An Overview of the Last Decade

Systematic Review of Systemic and Neuraxial Effects of Acetaminophen in Preclinical Models of Nociceptive Processing

Arsenic and its effect on immunity: A narrative review

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