Arsenic contamination: a potential hazard to the affected areas of West Bengal, India

Rahaman, S.; Sinha, Abhas Kumar; Pati, R.; Mukhopadhyay, D.

doi:10.1007/s10653-012-9460-4

Cited by 112 publications

(29 citation statements)

References 37 publications

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“…Looking at the arsenic concentration in potato, previous studies on arsenic-contaminated areas have presented values in a range from 0.081 to 1.5 mg/kg dw (Bhattacharya et al, 2010;Rahaman et al, 2013;Signes-Pastor et al, 2008) and 0.001-0.52 mg/kg fw (Biswas et al, 2013;Del Razo et al, 2002;Norton et al, 2013). This interval is overlapped by the minimum and maximum value of our analyzed samples (Table 3).…”

Section: Concentrations In Soil and Vegetablessupporting

confidence: 46%

An assessment of health risks associated with arsenic exposure via consumption of homegrown vegetables near contaminated glassworks sites

Uddh-Söderberg

Gunnarsson

Högmalm

et al. 2015

Science of The Total Environment

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Section: Concentrations In Soil and Vegetablessupporting

confidence: 46%

An assessment of health risks associated with arsenic exposure via consumption of homegrown vegetables near contaminated glassworks sites

Uddh-Söderberg

Gunnarsson

Högmalm

et al. 2015

Science of The Total Environment

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“…The range of arsenic concentration found in natural waters around the world varied from <0.0005 to >5 mg/L28, and there is a report that in West Bengal, India, people were exposed to arsenic at a maximum concentration of 3.7 mg/L in groundwater29. In this study, 25 mg/L of SA was used as high dose for rat exposure, which was approximately equivalent to 14.4 mg/L of arsenic, and was 2.3 mg/L for human30.…”

Section: Methodsmentioning

confidence: 99%

Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity

Huang

Luo²,

Alamdar

et al. 2016

Sci Rep

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Arsenic is a widespread metalloid in environment, whose exposure has been associated with a broad spectrum of toxic effects. However, a global view of arsenic-induced male reproductive toxicity is still lack, and the underlying mechanisms remain largely unclear. Our results revealed that arsenic exposure decreased testosterone level and reduced sperm quality in rats. By conducting an integrated proteomics and metabolomics analysis, the present study aims to investigate the global influence of arsenic exposure on the proteome and metabolome in rat testis. The abundance of 70 proteins (36 up-regulated and 34 down-regulated) and 13 metabolites (8 increased and 5 decreased) were found to be significantly altered by arsenic treatment. Among these, 19 proteins and 2 metabolites were specifically related to male reproductive system development and function, including spermatogenesis, sperm function and fertilization, fertility, internal genitalia development, and mating behavior. It is further proposed that arsenic mainly impaired spermatogenesis and fertilization via aberrant modulation of these male reproduction-related proteins and metabolites, which may be mediated by the ERK/AKT/NF-κB-dependent signaling pathway. Overall, these findings will aid our understanding of the mechanisms responsible for arsenic-induced male reproductive toxicity, and from such studies useful biomarkers indicative of arsenic exposure could be discovered.

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“…The World Health Organization (WHO) has fixed the maximum level of arsenic in drinking water to 10 ppb, and the Food and Agriculture Organization (FAO) has set a maximum arsenic level of 100 ppb in irrigation water (49). As shown in Fig.…”

Section: Acidithiobacillus Ferrooxidansmentioning

confidence: 99%

Paralogous Regulators ArsR1 and ArsR2 of Pseudomonas putida KT2440 as a Basis for Arsenic Biosensor Development

Fernández

Morel

Ramos

et al. 2016

Appl Environ Microbiol

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The remarkable metal resistance of many microorganisms is related to the presence of multiple metal resistance operons. Pseudomonas putida KT2440 can be considered a model for these microorganisms since its arsenic resistance is due to the action of proteins encoded by the two paralogous arsenic resistance operons ARS1 and ARS2. Both operons contain the genes encoding the transcriptional regulators ArsR1 and ArsR2 that control operon expression. We show here that purified ArsR1 and ArsR2 bind the trivalent salt of arsenic (arsenite) with similar affinities (~30 M), whereas no binding is observed for the pentavalent salt (arsenate). Furthermore, trivalent salts of bismuth and antimony showed binding to both paralogues. The positions of cysteines, found to bind arsenic in other homologues, indicate that ArsR1 and ArsR2 employ different modes of arsenite recognition. Both paralogues are dimeric and possess significant thermal stability. Both proteins were used to construct whole-cell, lacZ-based biosensors. Whereas responses to bismuth were negligible, significant responses were observed for arsenite, arsenate, and antimony. Biosensors based on the P. putida arsB1 arsB2 arsenic efflux pump double mutant were significantly more sensitive than biosensors based on the wild-type strain. This sensitivity enhancement by pump mutation may be a convenient strategy for the construction of other biosensors. A frequent limitation found for other arsenic biosensors was their elevated background signal and interference by inorganic phosphate. The constructed biosensors show no interference by inorganic phosphate, are characterized by a very low background signal, and were found to be suitable to analyze environmental samples. IMPORTANCE Arsenic is at the top of the priority list of hazardous compounds issued by the U.S. Agency for Toxic Substances and Disease. The reason for the stunning arsenic resistance of many microorganisms is the existence of paralogous arsenic resistance operons.Pseudomonas putida KT2440 is a model organism for such bacteria, and their duplicated ars operons and in particular their ArsR transcription regulators have been studied in depth by in vivo approaches. Here we present an analysis of both purified ArsR paralogues by different biophysical techniques, and data obtained provide valuable insight into their structure and function. Particularly insightful was the comparison of ArsR effector profiles determined by in vitro and in vivo experimentation. We also report the use of both paralogues to construct robust and highly sensitive arsenic biosensors. Our finding that the deletion of both arsenic efflux pumps significantly increases biosensor sensitivity is of general relevance in the biosensor field.A rsenic is omnipresent in nature and found in many environmental biotopes such as seawater, freshwater, soils, and rocks. It is either released through various natural processes such as weathering or hydrothermal emissions or generated by a number of anthropogenic activities such as the use of arse...

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Arsenic contamination: a potential hazard to the affected areas of West Bengal, India

Cited by 112 publications

References 37 publications

An assessment of health risks associated with arsenic exposure via consumption of homegrown vegetables near contaminated glassworks sites

An assessment of health risks associated with arsenic exposure via consumption of homegrown vegetables near contaminated glassworks sites

Integrated proteomics and metabolomics analysis of rat testis: Mechanism of arsenic-induced male reproductive toxicity

Paralogous Regulators ArsR1 and ArsR2 of Pseudomonas putida KT2440 as a Basis for Arsenic Biosensor Development

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