Arsenic and fluoride co-exposure affects the expression of apoptotic and inflammatory genes and proteins in mononuclear cells from children

Estrada-Capetillo, B.L.; Ortiz-Pérez, M. D.; Salgado‐Bustamante, Mariana; Calderón-Aranda, Emma S.; Rodríguez-Pinal, Cristian Jazmín; Reynaga-Hernández, Elizabeth; Corral-Fernández, Nancy E.; González‐Amaro, Roberto; Portales-Pérez, Diana Patricia

doi:10.1016/j.mrgentox.2014.01.006

Cited by 20 publications

(7 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Blood. Since peripheral blood reflects a systemic exposure to several chemical compounds, there are many studies investigating the effects of fluoride in these cells Children chronically exposed to fluoride at 5.3 mg/l in drinking water and in food cooked with the same water showed a lower percentage of CD25-and CD40-positive cells (73). The same findings were observed in others (74).…”

Section: Bonesupporting

confidence: 74%

Fluoride Induces Apoptosis in Mammalian Cells: In Vitro and In Vivo Studies

Ribeiro

Cardoso

Yujra

et al. 2017

View full text Add to dashboard Cite

Apoptosis is genetically programmed cell death, an irreversible process of cell senescence with characteristic features different from other cellular mechanisms of death such as necrosis. In the last years, apoptosis has been extensively studied in the scientific literature, because it has been established that apoptosis plays a crucial role following the time course of chronic degenerative diseases, such as cancer. Thus, several researchers have strugged to detect what chemical agents are able to inter fere with the apoptotic process. Thus, the purpose of this literature review is to assess if fluoride induces apoptosis in mammalian cells using in vivo and in vitro test systems. Certain mammalian cell types such as oral cells, blood and brain were exetensively investigated; the results showed that fluoride is able to induce apoptosis in both intrinsinc and extrinsic pathways. Moreover, other cells types have been poorly investigated such as bone, kidney and reproductive cells with conflicting results so far. Therefore, this area needs further investigation for the safety of human populations exposed to fluoride in a chronic way, as for example in developing countries.

show abstract

Section: Bonesupporting

confidence: 74%

Fluoride Induces Apoptosis in Mammalian Cells: In Vitro and In Vivo Studies

Ribeiro

Cardoso

Yujra

et al. 2017

View full text Add to dashboard Cite

show abstract

“…As-exposed children (mean UAs 40.3 μg/g Cr) demonstrated significantly higher MEC frequency per 1000 cells (2.20 vs 1.06) than the control (UAs 16.3 μg/g Cr) children in this study (Gamino-Gutierrez et al, 2013). Another study examining the children between the age of 6-12 years, who were chronically exposed to high levels of both As and fluoride in municipality area, showed alteration of expression patterns of CD25 and CD40 genes, an indication of reduced immune responses (Estrada-Capetillo et al, 2014). Effect of As exposure on the telomere length was studied among Asexposed male participants (n=76) who had WAs exposure above 10 μg/L with the controls who had low As exposure below 10 μg/L (n=112) living in Coahuila (Villarreal et al, 2019).…”

Section: Genotoxicity Cytotoxicity and Other Biochemical Effectsmentioning

confidence: 43%

Health effects of arsenic exposure in Latin America: An overview of the past eight years of research

Khan

Chakraborty

Bundschuh

et al. 2020

Science of The Total Environment

102

View full text Add to dashboard Cite

Studies conducted over the past eight years in Latin America (LA) have continued to produce new knowledge regarding health impacts of arsenic (As) in drinking water. We conducted a systematic review of 92 peer-reviewed English articles published between 2011 and 2018 to expand our understanding on these health effects. Majority of the LA studies on As have been conducted in Chile and Mexico. Additional data have emerged from As-exposed populations in Argentina,

show abstract

“…Elucidating arsenic-related health outcomes from environmental exposure is confounded by co-exposure to other agents such as lead, cadmium, fluoride, polyaromatic hydrocarbons, and pesticides ( Andrade et al 2015 ; Estrada-Capetillo et al 2014 ; Flora et al 2014 ; Huang et al 2013 ). For example, groundwater with high concentrations of arsenic often naturally contains high concentrations of fluoride ( Amini et al 2008 ).…”

Section: Exposure Assessments and Aggregate Exposuresmentioning

confidence: 99%

Arsenic and Environmental Health: State of the Science and Future Research Opportunities

Carlin

Naujokas²,

Bradham

et al. 2016

Environ Health Perspect

255

137

View full text Add to dashboard Cite

Background:Exposure to inorganic and organic arsenic compounds is a major public health problem that affects hundreds of millions of people worldwide. Exposure to arsenic is associated with cancer and noncancer effects in nearly every organ in the body, and evidence is mounting for health effects at lower levels of arsenic exposure than previously thought. Building from a tremendous knowledge base with > 1,000 scientific papers published annually with “arsenic” in the title, the question becomes, what questions would best drive future research directions?Objectives:The objective is to discuss emerging issues in arsenic research and identify data gaps across disciplines.Methods:The National Institutes of Health’s National Institute of Environmental Health Sciences Superfund Research Program convened a workshop to identify emerging issues and research needs to address the multi-faceted challenges related to arsenic and environmental health. This review summarizes information captured during the workshop.Discussion:More information about aggregate exposure to arsenic is needed, including the amount and forms of arsenic found in foods. New strategies for mitigating arsenic exposures and related health effects range from engineered filtering systems to phytogenetics and nutritional interventions. Furthermore, integration of omics data with mechanistic and epidemiological data is a key step toward the goal of linking biomarkers of exposure and susceptibility to disease mechanisms and outcomes.Conclusions:Promising research strategies and technologies for arsenic exposure and adverse health effect mitigation are being pursued, and future research is moving toward deeper collaborations and integration of information across disciplines to address data gaps.Citation:Carlin DJ, Naujokas MF, Bradham KD, Cowden J, Heacock M, Henry HF, Lee JS, Thomas DJ, Thompson C, Tokar EJ, Waalkes MP, Birnbaum LS, Suk WA. 2016. Arsenic and environmental health: state of the science and future research opportunities. Environ Health Perspect 124:890–899; http://dx.doi.org/10.1289/ehp.1510209

show abstract

Arsenic and fluoride co-exposure affects the expression of apoptotic and inflammatory genes and proteins in mononuclear cells from children

Cited by 20 publications

References 40 publications

Fluoride Induces Apoptosis in Mammalian Cells: In Vitro and In Vivo Studies

Fluoride Induces Apoptosis in Mammalian Cells: In Vitro and In Vivo Studies

Health effects of arsenic exposure in Latin America: An overview of the past eight years of research

Arsenic and Environmental Health: State of the Science and Future Research Opportunities

Contact Info

Product

Resources

About