volume 45, issue 17, P10229-10241 2017
DOI: 10.1093/nar/gkx647
View full text
|
Sign up to set email alerts
|
Share

Abstract: AbstractTermination of transcription is important for establishing gene punctuation marks. It is also critical for suppressing many of the pervasive transcription events occurring throughout eukaryotic genomes and coupling their RNA products to efficient decay. In human cells, the ARS2 protein has been implicated in such function as its depletion causes transcriptional read-through of selected gene terminators and because it physically interacts with the ribonucleolytic nuclear RNA exosome. Here, we study the …

Expand abstract