Arrhythmogenic right ventricular cardiomyopathy in a cat

Pugliese, Michela; Maestra, Rocky La; Gamba, Giulia La; Lanteri, Giovanni; Passantino, Annamaria

doi:10.6092/1828-6550/apmb.109.1.2021.ccs1

Cited by 1 publication

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“…Auto-antibodies against DSG2, proposed as a specific biomarker for all genetic forms of ACM and as a proof of autoimmunity resultant from ACM pathogenic gene variants, have been found in the sera of boxer dogs spontaneously manifesting the disease [ 41 ], but were never tested in ACM mouse models. Spontaneous feline ACM, characterized by right-ventricular disease, ventricular tachycardia, and fibro-fatty replacement of the myocardium, also has signs of inflammatory infiltrates [ 108 ].…”

Section: Modeling Myocardial Inflammation In Cardiomyopathies: Eviden...mentioning

confidence: 99%

Myocardial Inflammation as a Manifestation of Genetic Cardiomyopathies: From Bedside to the Bench

et al. 2023

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Over recent years, preclinical and clinical evidence has implicated myocardial inflammation (M-Infl) in the pathophysiology and phenotypes of traditionally genetic cardiomyopathies. M-Infl resembling myocarditis on imaging and histology occurs frequently as a clinical manifestation of classically genetic cardiac diseases, including dilated and arrhythmogenic cardiomyopathy. The emerging role of M-Infl in disease pathophysiology is leading to the identification of druggable targets for molecular treatment of the inflammatory process and a new paradigm in the field of cardiomyopathies. Cardiomyopathies constitute a leading cause of heart failure and arrhythmic sudden death in the young population. The aim of this review is to present, from bedside to bench, the current state of the art about the genetic basis of M-Infl in nonischemic cardiomyopathies of the dilated and arrhythmogenic spectrum in order to prompt future research towards the identification of novel mechanisms and treatment targets, with the ultimate goal of lowering disease morbidity and mortality.

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Section: Modeling Myocardial Inflammation In Cardiomyopathies: Eviden...mentioning

confidence: 99%