Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) in a Boxer

Arrhythmogenic right ventricular cardiomyopathy in two cats

“…ECG abnormalities have also been described in dogs with ARVC, and include ventricular tachycardia (Fernandez del Palacio and others 2001), left bundle branch block (Simpson and others 1994), intermittent ventricular bigeminy (Bright and McEntree 1995), supraventricular tachycardia associated with right bundle branch block (Mohr and Kirberger 2000) and atrioventricular nodal premature complexes (Boujon and Amberger 2003).…”

Ventricular tachycardia in English bulldogs with localised right ventricular outflow tract enlargement

“…ARVC has been reported in six dog breeds (Simpson and others 1994, Bright and And McEntee 1995, Mohr and others 2000, Fernandez del Palacio 2001, Boujon and Amberger 2003, Basso and others 2004, Santilli and others 2009) and in boxer dogs the presentation, familial transmission and pathology of ARVC has many similarities with the human clinical counterpart.…”

“…All canine cases reported have included the involvement of the right ventricle with either diffuse or segmental forms, the right atrium, the interventricular septum, the left ventricle and the left atrium. Right ventricle wall thinning was either diffuse or segmental and associated with a flattened appearance of trabeculae and prominent septoparietal bands (Simpson and others 1994, Bright and McEntee 1995, Mohr and others 2000, Fernandez del Palacio 2001, Boujon and Amberger 2003). Thirteen percent of boxers with ARVC had diffuse infiltration of the right ventricular myocardium with localised infundibular aneurysms (Basso and others 2004) while only one case of confirmed segmental RVOT ARVC has been reported (Santilli and others 2009).…”

“…In human beings VT arising from the right ventricle usually manifests as wide QRS complexes with a left bundle branch block (LBBB) morphology (O’Donnell and others 2003, Lerman and others 2004). Right VT has been described in dogs with ARVC (Simpson and others 1994, Bright and McEntee 1995, Mohr and Kirberger 2000, Fernandez del Palacio and others 2001, Boujon and Amberger 2003, Basso and others 2004, Santilli and others 2009). and in a canine model of RVOT‐VT (Zhou and others 2006).…”

“…A hereditary form of ARVC associated with sudden death has been described in boxers with an autosomal dominant trait with reduced penetrance (Meurs and others 1999, Boujon and Amberger 2003, Basso and others 2004, Meurs and others 2007, Oxford and others 2007). So far a specific gene mutation of striatin has been identified in these dogs (Meurs and others 2010), together with a lower expression of cardiac ryanodine receptors, myocardial calstabin‐2 and connexin 43 junction protein (Meurs and others 2006, Oxford and others 2007, Oyama and others 2008).…”