Arrhythmias in Cardiac Sarcoidosis Bench to Bedside

Rosenfeld, Lynda E.; Chung, Mina K.; Harding, Clifford V.; Spagnolo, Paolo; Grünewald, Johan; Appelbaum, Jason; Sauer, William H.; Culver, Daniel A.; Joglar, José A.; Lin, Ben A.; Jellis, Christine; Dickfeld, Timm; Kwon, Deborah; Miller, Edward J.; Cremer, Paul; Bogun, Frank; Kron, Jordana; Bock, Ashley; Mehta, Davendra; Leis, Paul; Siontis, Konstantinos C.; Kaufman, Elizabeth S.; Crawford, Thomas; Zimetbaum, Peter; Zishiri, Edwin; Singh, Jagmeet P.; Ellenbogen, Kenneth A.; Chrispin, Jonathan; Quadri, Syed M.; Vincent, Logan; Patton, Kristen K.; Kalbfleish, Steven; Callahan, Thomas; Murgatroyd, Francis; Judson, Marc A.; Birnie, David H.; Okada, David R.; Maulion, Christopher; Bhat, Pavan; Bellumkonda, Lavanya; Blankstein, Ron; Cheng, Richard K.; Farr, Maryjane; Estep, Jerry D.

doi:10.1161/circep.120.009203

Cited by 18 publications

(14 citation statements)

References 91 publications

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“…As with our patient, he did have multiple episodes of symptomatic bradycardia when hospitalized. Other known manifestations of cardiac sarcoidosis involve heart block, chest pain, arrhythmias, and shortness of breath; the latter of which the patient also endorsed and was hospitalized for [16]. Further workup to include EKG, echocardiograms, and evaluation for ICD should be pursued.…”

Section: Extrapulmonary Manifestationsmentioning

confidence: 99%

Sarcoid Here, Sarcoid There, Sarcoid Everywhere

Iskander¹,

Patel²,

Patel³

et al. 2023

Cureus

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Although usually more associated with the lungs, sarcoidosis can have multiple extrapulmonary manifestations. We present a case of a patient with previous biopsy-proven sarcoidosis who was admitted to the hospital secondary to worsening shortness of breath. The patient was found to be positive for Respiratory Syncytial Virus (RSV) which was believed to have exacerbated his pulmonary symptoms. He was treated with IV steroids, nebulizers, and antibiotics which ultimately helped relieve his symptoms. In terms of his sarcoidosis, he was previously treated in the past with steroids in regards to this pathology (which is the mainstay of treatment); while on the regimen, the patient noted his breathing was improved. Of note, he did also have a history of renal cell carcinoma (RCC) status post nephrectomy which was initially evaluated for possible sarcoidosis involvement. This medical therapy could also have been the reason his sarcoidosis did not progress to involve other organs.

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Section: Extrapulmonary Manifestationsmentioning

confidence: 99%

Sarcoid Here, Sarcoid There, Sarcoid Everywhere

Iskander¹,

Patel²,

Patel³

et al. 2023

Cureus

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“…6 Cardiac sarcoidosis is a systemic granulomatous disease of uncertain etiology with a predilection for North Europeans and Africans but appears to be due to an initial environmental antigen that stimulates an immune response leading to granuloma formation. 7 Cardiac sarcoidosis is usually considered in the setting of unexplained atrioventricular block. However, ventricular arrhythmias, although rare, can be the initial clinical manifestation, and their presence has been associated with a 9% to 34% 5-year risk of sudden cardiac death.…”

Section: Clinical Coursementioning

confidence: 99%

“…Cardiac sarcoidosis is a systemic granulomatous disease of uncertain etiology with a predilection for North Europeans and Africans but appears to be due to an initial environmental antigen that stimulates an immune response leading to granuloma formation . Cardiac sarcoidosis is usually considered in the setting of unexplained atrioventricular block.…”

Section: Clinical Coursementioning

confidence: 99%

Palpitations and Shortness of Breath—Just a “Bump in the Road” or Something More?

2023

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“…У больных с оксалозом сердца обычно появляется полная атриовентрикулярная блокада и желудочковые нарушения проводимости [20]. При саркоидозе сердца выявлялись нарушения проводимости у 75% пациентов [21].…”

Section: мнение по проблемеunclassified

Red flags to diagnose infiltrative cardiomyopathies

et al. 2023

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Infiltrative cardiomyopathies are a group of diseases characterized by the deposition of abnormal substances in heart tissues, which leads to thickening of the walls or dilation of chambers with a secondary decrease in wall thickness and the development of diastolic, less often systolic, ventricular dysfunction. Most often, these are progressive diseases that, in the absence of adequate therapy, have an unfavorable prognosis. Clinical manifestations of infiltrative cardiac diseases are variable, which often leads to diagnostic difficulties and errors. In most cases, specific laboratory and morphological tests are required to confirm or clarify the diagnosis. Early diagnosis is critical to initiating therapy and improving patient prognosis. This article provides characteristic signs and symptoms, the so-called "red flags", making it possible to suspect infiltrative cardiomyopathies, diagnose them at an early stage and start life-saving therapy.

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Arrhythmias in Cardiac Sarcoidosis Bench to Bedside

Cited by 18 publications

References 91 publications

Sarcoid Here, Sarcoid There, Sarcoid Everywhere

Sarcoid Here, Sarcoid There, Sarcoid Everywhere

Palpitations and Shortness of Breath—Just a “Bump in the Road” or Something More?

Red flags to diagnose infiltrative cardiomyopathies

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