Arrhythmia Risk Profile and Ventricular Repolarization Indices in COVID-19 Patients: A Systematic Review and Meta-Analysis

Tondas, Alexander Edo; Mulawarman, Rido; Trifitriana, Monica; Nurmaini, Siti; Irfannuddin, Irfannuddin

doi:10.3855/jidc.13922

Cited by 8 publications

(11 citation statements)

References 23 publications

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“…Two meta-analyses studied the relationship between COVID-19 and ventricular arrhythmia. However, one of them focused on the patients after chloroquine or hydroxychloroquine treatment (45), while another explored the effect of COVID-19 on QTd, Tp-e/QTc ratio, and Tpe interval (46). In addition, two meta-analyses described the relationship between COVID-19 and all types of arrhythmias (47,48).…”

Section: Compassion With the Previous Studymentioning

confidence: 99%

The Prevalence and Associated Death of Ventricular Arrhythmia and Sudden Cardiac Death in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis

Tan

Huang

Mei

et al. 2022

Front. Cardiovasc. Med.

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BackgroundArrhythmia is a very common complication of coronavirus disease 2019 (COVID-19); however, the prevalence of ventricular arrhythmia and associated outcomes are not well-explored. Here, we conducted a systematic review and meta-analysis to determine the prevalence and associated death of ventricular arrhythmia and sudden cardiac death (SCD) in patients with COVID-19.MethodsDatabases of PubMed, Cochrane Library, Embase, and MdeRxiv were searched. Studies that could calculate the prevalence of ventricular arrhythmia/SCD during hospital admission or associated death in patients with COVID-19 were included. The study was registered with the PROSPERO (CRD42021271328).ResultsA total of 21 studies with 13,790 patients were included. The pooled prevalence of ventricular arrhythmia was 5% (95% CI: 4–6%), with a relatively high-SCD prevalence (1.8% in hospitalized COVID-19 and 10% in deceased cases of COVID-19). Subgroup analysis showed that ventricular arrhythmia was more common in patients with elevated cardiac troponin T [ES (effect size): 10%, 95% CI: −0.2 to 22%] and in European (ES: 20%, 95% CI: 11–29%) populations. Besides, ventricular arrhythmia was independently associated with an increased risk of death in patients with COVID-19 [odds ratio (OR) = 2.83; 95% CI: 1.78–4.51].ConclusionVentricular arrhythmia and SCD resulted as a common occurrence with a high prevalence in patients with COVID-19 admitted to the hospital. Furthermore, ventricular arrhythmia significantly contributed to an increased risk of death in hospitalized patients with COVID-19. Clinicians might be vigilant of ventricular arrhythmias for patients with COVID-19, especially for severe cases.Systematic Review Registrationwww.york.ac.uk/inst/crd, identifier: CRD42021271328.

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Section: Compassion With the Previous Studymentioning

confidence: 99%

The Prevalence and Associated Death of Ventricular Arrhythmia and Sudden Cardiac Death in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis

Tan

Huang

Mei

et al. 2022

Front. Cardiovasc. Med.

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“…The literature search provided 810 reviews, 40 of which were eligible for full-text review. After reviewing the full text, 26 meta-analysis studies were eligible for inclusion 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 . The study selection process is shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Incidence of cardiac complications following COVID-19 infection: An umbrella meta-analysis study

et al. 2022

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Background COVID-19 causes fatal cardiac damages. Despite many overwhelming meta-analysis related to cardiac complications following COVID-19 disease, no umbrella meta-analysis study has been conducted. Objectives We aimed to report the summarized pooled incidences of cardiac complications in the overall, critically ill, and deceased patients, compare the cardiac complications between the severe/non-severe or deceased/non-deceased patients, and also compare poor outcomes between patients with/without acute myocardial injury (AMI). Methods PubMed, Scopus, web of science, Cochrane, ProQuest, Springer, Sage journals were searched before April 2021. After assessing the quality and duplicate data, data were run by the random/fixed-effect models, I2 heterogeneity index, Egger's test, and sensitivity analysis. Results After removing duplicate data, in the overall COVID-19 patients, the pooled incidence of AMI, heart failure, arrhythmia, cardiac arrest, and acute coronary syndrome (ACS) were 21%, 14%, 16%, 3.46%, and 1.3% respectively. In the patients with severe disease, the pooled incidence of AMI and shock were 33 and 35%, respectively. Similarly, in the deceased COVID-19 patients, the pooled incidence rate of AMI and arrhythmia were 56% and 47.5%, respectively. The patients with severe disease were at higher risk of AMI (RR = 5.27) and shock (OR = 20.18) compared with the non-severe cases. Incidence of AMI was associated with transfer to the intensive care units (ICU) (RR = 2.92) and mortality (RR=2.57, OR = 8.36), significantly. Conclusion Cardiac complications were found to be increased alarmingly in COVID-19 patients. Baseline and during hospitalization checking with electrocardiography, echocardiography, and measuring of cardiac biomarkers should be applied.

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“…Apart from that, the protein name corresponding to the CaATP_NAI domain of S protein was found from the domain search result file: A0A365XXB7 CaATP_NAI domain-containing protein (Chitinophaga Flava). Besides, the motif sequence corresponding to this protein is “WRHVVHKNMSHRWRM” [ 2 – 31 ], while the S11 of the A0A365XXB7 protein is mutated to A1087 on the S protein. A study shows that due to S/A mutation in N-terminal inhibitory (or the regulatory domain), Ca 2+ -ATPase activity is not inhibited by phosphorylation [ 80 ].…”

Section: Resultsmentioning

confidence: 99%

“…I NaL prolongs the increase in action potential (AP), leading to arrhythmias and sudden cardiac death [ 30 ]. Here, it should be mentioned that some ECG markers in patients with COVID-19 characterize that SARS-CoV-2 infection is associated with abnormal ion channel function, including Tp-e/QTc, Tp-e interval, and QTd increasing significantly [ 31 ], as well as QRS and QTc [ 32 ], while TDR decreasing, and iCEB value changing dramatically [ 32 ]. The epithelial sodium channel α subunit (ENaC-α) is often found in the same human lung and respiratory cells as ACE2.…”

Section: Introductionmentioning

confidence: 99%

COVID-19: the CaMKII-like system of S protein drives membrane fusion and induces syncytial multinucleated giant cells

Liu

2021

Immunol Res

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The SARS-CoV-2 S protein on the membrane of infected cells can promote receptor-dependent syncytia formation, relating to extensive tissue damage and lymphocyte elimination. In this case, it is challenging to obtain neutralizing antibodies and prevent them through antibodies effectively. Considering that, in the current study, structural domain search methods are adopted to analyze the SARS-CoV-2 S protein to find the fusion mechanism. The results show that after the EF-hand domain of S protein bound to calcium ions, S2 protein had CaMKII protein activities. Besides, the CaMKII_AD domain of S2 changed S2 conformation, facilitating the formation of HR1-HR2 six-helix bundles. Apart from that, the Ca 2+ -ATPase of S2 pumped calcium ions from the virus cytoplasm to help membrane fusion, while motor structures of S drove the CaATP_NAI and CaMKII_AD domains to extend to the outside and combined the viral membrane and the cell membrane, thus forming a calcium bridge. Furthermore, the phospholipid-flipping-ATPase released water, triggering lipid mixing and fusion and generating fusion pores. Then, motor structures promoted fusion pore extension, followed by the cytoplasmic contents of the virus being discharged into the cell cytoplasm. After that, the membrane of the virus slid onto the cell membrane along the flowing membrane on the gap of the three CaATP_NAI. At last, the HR1-HR2 hexamer would fall into the cytoplasm or stay on the cell membrane. Therefore, the CaMKII_like system of S protein facilitated membrane fusion for further inducing syncytial multinucleated giant cells.

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Arrhythmia Risk Profile and Ventricular Repolarization Indices in COVID-19 Patients: A Systematic Review and Meta-Analysis

Cited by 8 publications

References 23 publications

The Prevalence and Associated Death of Ventricular Arrhythmia and Sudden Cardiac Death in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis

The Prevalence and Associated Death of Ventricular Arrhythmia and Sudden Cardiac Death in Hospitalized Patients With COVID-19: A Systematic Review and Meta-Analysis

Incidence of cardiac complications following COVID-19 infection: An umbrella meta-analysis study

COVID-19: the CaMKII-like system of S protein drives membrane fusion and induces syncytial multinucleated giant cells

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