Arresting supporters: targeting neutrophils in metastasis

Acharyya, Swarnali; Massagué, Joan

doi:10.1038/cr.2016.17

Cited by 16 publications

(16 citation statements)

References 12 publications

(18 reference statements)

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“…Our findings are clinically relevant because targeting the signals that activate actin cytoskeleton remodeling or actin polymerization could suppress EMT and thus prevent or treat tumor invasion and metastasis. Indeed, previous studies reported that targeting microenvironment factors, such as neutrophils, prevented tumor metastasis …”

Section: Discussionmentioning

confidence: 99%

“…Indeed, previous studies reported that targeting microenvironment factors, such as neutrophils, prevented tumor metastasis. (30,31) This actin cytoskeleton remodeling-induced EMT is, at least in part, caused by the enhanced cellular hypoxic responses attributed to increased cellular ATP and oxygen demand. Interestingly, the resulting EMT was reversed by ATP supplementation and treatment with inhibitors of actin polymerization, such as CTCD.…”

Section: Discussionmentioning

confidence: 99%

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Actin cytoskeleton remodeling drives epithelial‐mesenchymal transition for hepatoma invasion and metastasis in mice

et al. 2018

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Simultaneously activation of actin cytoskeleton remodeling by intrinsic (such as KLHL23 down-regulation) or microenvironment cues is crucial for cell-density-dependent and hypoxia-mediated EMT, providing a mechanistic link between large tumor size and invasion/metastasis. Our findings provide a means of developing the prevention and treatment strategies for tumor invasion and metastasis. (Hepatology 2018;67:2226-2243).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Actin cytoskeleton remodeling drives epithelial‐mesenchymal transition for hepatoma invasion and metastasis in mice

et al. 2018

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“…A lung metastasis model of murine breast cancer demonstrated that some special neutrophils like CXCR2C neutrophils are responsible for the pro-metastatic effect of mesenchymal stromal cells (MSCs). 146 Recently Wculek et al defined the role of neutrophils as mediators of metastatic initiation by modifying the pre-metastatic lung microenvironment in breast cancer mouse models, 147,148 suggesting that immune cells regulate the formation of metastatic niches.…”

Section: Immune Cellsmentioning

confidence: 99%

Breast cancer lung metastasis: Molecular biology and therapeutic implications

Jin

Han

Siegel

et al. 2018

Cancer Biology & Therapy

221

164

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Distant metastasis accounts for the vast majority of deaths in patients with cancer. Breast cancer exhibits a distinct metastatic pattern commonly involving bone, liver, lung, and brain. Breast cancer can be divided into different subtypes based on gene expression profiles, and different breast cancer subtypes show preference to distinct organ sites of metastasis. Luminal breast tumors tend to metastasize to bone while basal-like breast cancer (BLBC) displays a lung tropism of metastasis. However, the mechanisms underlying this organ-specific pattern of metastasis still remain to be elucidated. In this review, we will summarize the recent advances regarding the molecular signaling pathways as well as the therapeutic strategies for treating breast cancer lung metastasis.

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“…Similar to other infiltrating immune cells, also neutrophils can be targeted in cancer therapy. Acharyya and Massague suggested to interfere with downstream targets of the MAPK cascade such as leukotriene biosynthesis, CXCR2, Anti‐Bv8, and G‐CSF antibodies . Scientists have also started to explore the therapeutic potential of platelet targeting, which is very promising due to the very high number of platelets in the body.…”

Section: Therapeutic Modulation Of Immunitymentioning

confidence: 99%

“…Acharyya and Massague suggested to interfere with downstream targets of the MAPK cascade such as leukotriene biosynthesis, CXCR2, Anti-Bv8, and G-CSF antibodies. [68] Scientists have also started to explore the therapeutic potential of platelet targeting, which is very promising due to the very high number of platelets in the body. The platelet expressed collagen receptor GP VI was shown by Boilard et al to be a key trigger for platelet microparticle generation in arthritis pathophysiology.…”

Section: Targeting Immune Cell-related Diseasementioning

confidence: 99%

Immunomodulatory Nanomedicine

Bartneck

2017

Macromolecular Bioscience

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Immunity has a major impact on inflammatory diseases and cancer, and biologics targeting immune cells and their factors reach a quarter trillion of market volume by this year. Adaptive leukocytes have recently been engaged in cancer immunotherapy, whereas modulation of the innate immune cells, specifically macrophages, is expected as next breakthrough. With patents of major biologics expiring, nanomedicine has the potential to substitute therapeutic proteins by using miniaturized macromolecules. This review includes an overview on the involvement of major immune cell types into disease and a summary on selected current therapies based on biologics and small molecules. Novel developments in nanomedicine‐based immunotherapies, including associated chances and risks, are presented.

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Arresting supporters: targeting neutrophils in metastasis

Cited by 16 publications

References 12 publications

Actin cytoskeleton remodeling drives epithelial‐mesenchymal transition for hepatoma invasion and metastasis in mice

Actin cytoskeleton remodeling drives epithelial‐mesenchymal transition for hepatoma invasion and metastasis in mice

Breast cancer lung metastasis: Molecular biology and therapeutic implications

Immunomodulatory Nanomedicine

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