Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat

Madsén, Torsten; Kristjansen, Paul E.G.; Bolwig, Tom G.; Wörtwein, Gitta

doi:10.1016/s0306-4522(03)00199-4

Cited by 422 publications

(315 citation statements)

References 38 publications

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“…To circumvent some of the problems associated with systemic administration of cytostatic agents such as MAM, some studies have used localized irradiation to reduce the population of newly generated cells in the DG (Madsen et al, 2003;Raber et al, 2004;Rola et al, 2004;Snyder et al, 2005). Moreover, irradiation has the advantage over antimitotic agents in that the population of new cells is usually depleted completely rather than just reduced.…”

Section: Evidence In Favormentioning

confidence: 99%

“…These studies have reported deficits in various types of hippocampal-dependent learning tasks. For example, the performance of irradiated rats was impaired on a hippocampal-dependent place recognition task, but not on an object recognition task, which is not dependent on the hippocampus (Madsen et al, 2003;Rola et al, 2004). However, like the antimitotic agents, there are some possible side effects of using irradiation to block adult neurogenesis, which could inadvertently affect performance.…”

Section: Evidence In Favormentioning

confidence: 99%

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Is there a link between adult neurogenesis and learning?

2006

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During the past several years, evidence has accumulated suggesting a relationship between newly born cells in the hippocampus and various types of learning and memory. However, most of the evidence is correlational and some of it does not agree. This review discusses both sides of this issue, considering the effects of learning on the production of new neurons in the dentate gyrus and the question of whether newly born cells participate in learning and memory.

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Section: Evidence In Favormentioning

confidence: 99%

Section: Evidence In Favormentioning

confidence: 99%

Is there a link between adult neurogenesis and learning?

2006

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“…Recently, the hippocampus has been recognized as one of the regions where neural stem cells (NSCs) continue to proliferate and generate neurons throughout life. In the animal model of cranial irradiation, neural stem/precursor cells in the hippocampus undergo apoptosis, and neurogenesis is suppressed (Peissner et al, 1999;Madsen et al, 2003;Limoli et al, 2004). Monje et al(2002) studied the association between the radiation effects on NSCs and changes in the microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun NH2-terminal kinase (JNK) pathway

et al. 2006

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“…The effect of radiation was dose dependent, with cell death in the proliferating cells occurring within 3 to 6 hours after treatment, and lasted at least up to 120 days after irradiation [63]. In the learning tasks that are known to require hippocampus-controlled memory function (eg, place-recognition task [64], spatial learning in the Barnes maze [65]), the mice with reduced hippocampal neurogenesis performed more poorly than controls, whereas they were not impaired in hippocampus-independent learning (eg, object-recognition task [64], elevated plus maze [65]). Similar dependency on hippocampus-related function was observed in trace conditioning tasks [60,61] and in the basic non-matching-to-sample (NMTS) task, in which an animal must associate stimuli that are separated in time.…”

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confidence: 99%

Adult Neurogenesis and Hippocampal Memory Function: New Cells, More Plasticity, New Memories?

Kitabatake

Sailor

Ming

et al. 2007

Neurosurgery Clinics of North America

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Memory consists of several separate entities that depend on various brain systems [1]. Clinical and behavioral evidence suggests that the hippocampus and the surrounding anatomically associated regions serve a critical role in learning and memory [2]. In the 1960s, the outlines of the essential neural substrates of memory were gradually elucidated based on analyzing the effects of therapeutic surgical lesions of the bilateral medial temporal lobes to suppress uncontrollable epilepsy in a patient [3]. Although the operation was effective in controlling the patient's epilepsy, one unexpected consequence was that he became profoundly amnesic while retaining his intelligence and perceptual and motor functions. Similar cases were also seen in other patients with damage to the hippocampal formation and surrounding medial temporal lobe structures [4]. These individuals had severe amnesia for episodic events, although other forms of learning and memory-semantic, perceptual, procedural, and simple forms of conditioning-were spared. It is now believed that the hippocampal formation has a central role in declarative memory, the ability to recollect everyday facts and events consciously [5]. The unique anatomy, electrophysiologic characteristics, and key roles in memory formation have made the hippocampus an attractive target of research for neuroscientists.For decades, it was believed that neurogenesis only occurred during embryonic stages in the mammalian central nervous system (CNS), making the brain one of the few mammalian organs incapable of replenishing its functional cell population throughout life [6]. In the 1960s, seminal studies by Altman and Das [7][8][9] provided the first evidence that new neurons were generated in the postnatal mammalian brain. In 1992, Reynolds and Weiss [10] isolated multipotent neural stem/progenitor cells (NSCs) from the adult rodent brain and characterized them in vitro. Studies in the 1990s confirmed that, contrary to long-held dogma, NSCs reside in the adult CNS and active neurogenesis occurs in discrete regions of the adult brain across various mammalian species, including mice, rats, monkeys, and humans [11][12][13][14]. Only recently has it been recognized that adult neurogenesis replicates the complex process of neuronal development to generate functionally integrated new neurons ( Fig. 1) [15][16][17]. A role for these postnatally generated cells in learning was first suggested by Altman and Das in the 1960s [7-9,18]. Later, Nottebohm [19] directly tested the role of * Corresponding author: shongju1@jhmi.edu (H. Song). HHS Public Access Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript adult-generated neurons in song learning in birds. Subsequent work in rodents has led to the idea that adult neurogenesis is important for learning and memory of spatial information.The discovery of adult neurogenesis has generated significant interest, especially in regard to the hippocampus, not only for neuroscientists but for physicians who are engaged in treating various ...

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Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat

Cited by 422 publications

References 38 publications

Is there a link between adult neurogenesis and learning?

Is there a link between adult neurogenesis and learning?

Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun NH2-terminal kinase (JNK) pathway

Adult Neurogenesis and Hippocampal Memory Function: New Cells, More Plasticity, New Memories?

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