Arrested Acetylene-Induced Pulmonary and Testicular Toxicity in Rats Through Treatment With Polyphenols

Oluwabayo, Tanitoluwa; Akinmoladun, Afolabi Clement; Akindahunsi, A. A.

doi:10.1080/01480545.2022.2066115

Cited by 1 publication

(1 citation statement)

References 23 publications

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“…Molecular dynamics simulation experiments by Samova et al found that BPA can bind to steroid-binding proteins to reduce their activity, whereas quercetin can compete with BPA, and this seems to be a possible mechanism by which quercetin reduces the testicular toxicity of BPA [89]. In addition to these effects, quercetin has been shown in numerous studies to be protective against testicular damage induced by other environmental pollutants such as crude oil vapor (COV) [90], diesel exhaust particles (DEPs) [91], polychlorinated biphenyls (PCBs) [92], carbon tetrachloride (CCl4) [93], 4-nitrophenol (PNP) [94], 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [95], acetylene [96], and phthalates (PEs) [97,98]. The protective effects of quercetin on exposure to different environmental pollutants are described in Table 1.…”

Section: Other Environmental Pollutants Exposurementioning

confidence: 99%

Pharmacological Activity of Flavonoid Quercetin and Its Therapeutic Potential in Testicular Injury

Zhang

Tang

et al. 2023

Nutrients

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Quercetin is a natural flavonoid widely found in natural fruits and vegetables. Recent studies have shown that quercetin mediates multiple beneficial effects in a variety of organ damage and diseases, and is considered a healthcare supplement with health-promoting potential. Male infertility is a major health concern, and testicular damage from multiple causes is an important etiology. Previous studies have shown that quercetin has a protective effect on reproductive function. This may be related to the antioxidant, anti-inflammatory, and anti-apoptotic biological activities of quercetin. Therefore, this paper reviews the mechanisms by which quercetin exerts its pharmacological activity and its role in testicular damage induced by various etiologies. In addition, this paper compiles the application of quercetin in clinical trials, demonstrating its practical effects in regulating blood pressure and inhibiting cellular senescence in human patients. However, more in-depth experimental studies and clinical trials are needed to confirm the true value of quercetin for the prevention and protection against testicular injury.

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