Arrays of graphene-quantum dots-supported DNA oligonucleotides as self-indicating porphyrin carriers

Monteiro, Ana Rita; Ramos, Catarina; Fateixa, Sara; Neves, Maria da Graça; Trindade, Tito

doi:10.1039/d3nj03280a

Cited by 2 publications

(2 citation statements)

References 75 publications

(109 reference statements)

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“…Trindade and co-workers have combined carbon nanomaterials (e. g. GO sheets) with porphyrins and phthalocyanines to create nanosystems that detect DNA G-quadruplex. [27,129,130] The Raman imaging analysis on the GO/porphyrin nanosystem has shown that the porphyrin molecules are predominantly located at the edges of GO through electrostatic attractions and at the core through van der Waals and π-π stacking interactions. [27] The same analysis after the spectrofluorimetric titrations of the GO/porphyrin with DNA G-quadruplex led to fluorescence recovery because the porphyrin molecules linked through electrostatic interactions were detached from the surface of the nanosystem to interact with the G-quadruplex.…”

Section: Raman Imaging Of 2d Materials and Its Application In Sersmentioning

confidence: 99%

Surface‐Enhanced Raman Scattering Using 2D Materials

Pinto de Sousa,

Fateixa,

Trindade

2024

Chemistry A European J

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The use of surface‐enhanced Raman scattering (SERS) as a technique for detecting small amounts of (bio)chemical analytes has become increasingly popular in various fields. While gold and silver nanostructures have been extensively studied as SERS substrates, the availability of other types of substrates is currently expanding the applications of this spectroscopic method. Recently, researchers have begun exploring two‐dimensional (2D) materials (e.g., graphene‐like nanostructures) as substrates for SERS analysis. These materials offer unique optical properties, a well‐defined structure, and the ability to modify their surface chemistry. As a contribution to advance this field, this concept article highlights the significance of understanding the chemical mechanism that underlies the experimental Raman spectra of chemisorbed molecules onto 2D materials’ surfaces. Therefore, the article discusses recent advancements in fabricating substrates using 2D layered materials and the synergic effects of using their metallic composites for SERS applications. Additionally, it provides a new perspective on using Raman imaging in developing 2D materials as analytical platforms for Raman spectroscopy, an exciting emerging research area with significant potential.

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Section: Raman Imaging Of 2d Materials and Its Application In Sersmentioning

confidence: 99%

Surface‐Enhanced Raman Scattering Using 2D Materials

Pinto de Sousa,

Fateixa,

Trindade

2024

Chemistry A European J

Self Cite

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“…Controlled reaction conditions prevent excessive grafting so that the biomolecules remain accessible for recognition. Amine-epoxides readily form under mild conditions to tether amino-modified oligonucleotides [ 55 ]. This provides an efficient approach to tethering amino-modified oligonucleotides or other amine-containing biomolecules.…”

Section: The Synthesis and Modification Of Graphene Materialsmentioning

confidence: 99%

Strategies and Applications of Graphene and Its Derivatives-Based Electrochemical Sensors in Cancer Diagnosis

Fu,

Zheng,

et al. 2023

Molecules

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Graphene is an emerging nanomaterial increasingly being used in electrochemical biosensing applications owing to its high surface area, excellent conductivity, ease of functionalization, and superior electrocatalytic properties compared to other carbon-based electrodes and nanomaterials, enabling faster electron transfer kinetics and higher sensitivity. Graphene electrochemical biosensors may have the potential to enable the rapid, sensitive, and low-cost detection of cancer biomarkers. This paper reviews early-stage research and proof-of-concept studies on the development of graphene electrochemical biosensors for potential future cancer diagnostic applications. Various graphene synthesis methods are outlined along with common functionalization approaches using polymers, biomolecules, nanomaterials, and synthetic chemistry to facilitate the immobilization of recognition elements and improve performance. Major sensor configurations including graphene field-effect transistors, graphene modified electrodes and nanocomposites, and 3D graphene networks are highlighted along with their principles of operation, advantages, and biosensing capabilities. Strategies for the immobilization of biorecognition elements like antibodies, aptamers, peptides, and DNA/RNA probes onto graphene platforms to impart target specificity are summarized. The use of nanomaterial labels, hybrid nanocomposites with graphene, and chemical modification for signal enhancement are also discussed. Examples are provided to illustrate applications for the sensitive electrochemical detection of a broad range of cancer biomarkers including proteins, circulating tumor cells, DNA mutations, non-coding RNAs like miRNA, metabolites, and glycoproteins. Current challenges and future opportunities are elucidated to guide ongoing efforts towards transitioning graphene biosensors from promising research lab tools into mainstream clinical practice. Continued research addressing issues with reproducibility, stability, selectivity, integration, clinical validation, and regulatory approval could enable wider adoption. Overall, graphene electrochemical biosensors present powerful and versatile platforms for cancer diagnosis at the point of care.

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Arrays of graphene-quantum dots-supported DNA oligonucleotides as self-indicating porphyrin carriers

Abstract: The functionalization of deoxyribonucleic acid (DNA) with nanomaterials is a promising strategy to optimize the loading and efficiency of drugs in targeted clinical therapies. Herein we report a novel approach...

Cited by 2 publications

References 75 publications

Surface‐Enhanced Raman Scattering Using 2D Materials

Surface‐Enhanced Raman Scattering Using 2D Materials

Strategies and Applications of Graphene and Its Derivatives-Based Electrochemical Sensors in Cancer Diagnosis

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