Arp2/3 complex-dependent actin regulation protects the survival of tissue-resident mast cells
Lukas Kaltenbach,
Michael Mihlan,
Svenja Ulferts
et al.
Abstract:Actin network dynamics are pivotal in governing the motility and effector functions of immune cells. The Arp2/3 complex is a key regulator of actin filament branching, with mutations in its subunits being linked with human immunodeficiencies. While known for its role in phagocytosis and cell migration, our study uncovers a critical role of the Arp2/3 complex in safeguarding the tissue residency of mast cells (MCs), essential immune cells in allergies, venom detoxification and antigen-specific avoidance. Mechan… Show more
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