Arousability as a trait predisposition to insomnia: multidimensional structure and clinical utility of the Spanish and English versions of the Arousal Predisposition Scale

Puzino, Kristina; Frye, Sara S.; LaGrotte, Caitlin; Vgontzas, Alexandros N.; Calhoun, Susan L.; Fernández-Mendoza, Julio

doi:10.1016/j.sleep.2021.02.033

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…Although insomnia subtype comparison was underpowered, participants with isolated middle insomnia had a similar proportion of low AT as compared to other insomnia subtypes. Arousability is a trait of insomnia that can be defined as the physiological, cognitive, emotional, and behavioral responsiveness of individuals to particular variations in environmental conditions, particularly stressful ones 6 . Arousability can be determined using self-reported instruments 24 and has been associated with insomnia severity as measured by the ISI 6,25 .…”

Section: Discussionmentioning

confidence: 99%

“…Arousability is a trait of insomnia that can be defined as the physiological, cognitive, emotional, and behavioral responsiveness of individuals to particular variations in environmental conditions, particularly stressful ones 6 . Arousability can be determined using self-reported instruments 24 and has been associated with insomnia severity as measured by the ISI 6,25 . The similar proportion of low AT between COMISA and OSA-only participants and among isolated middle and other insomnia subtypes suggest that the higher arousability found among insomnia participants is a different phenomenon than the ventilatoty effort-related arousal threshold.…”

Section: Discussionmentioning

confidence: 99%

“…Arousability may describe a particular phenotypical trait of insomnia patients 5 . Arousability in these patients can be defined as the physiological, cognitive, emotional, and behavioral responsiveness of individuals to particular variations in environmental stressful conditions 6 and is associated with insomnia severity as measured by the Insomnia Severity Index (ISI) 6 .…”

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confidence: 99%

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Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA)

Yanagimori

Fernandes

Garcia

et al. 2023

Sci Rep

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Insomnia and obstructive sleep apnea (OSA) are common sleep disorders and frequently coexist (COMISA). Arousals from sleep may be a common link explaining the frequent comorbidity of both disorders. Respiratory arousal threshold (AT) is a physiologic measurement of the level of respiratory effort to trigger an arousal from sleep. The impact of COMISA on AT is not known. We hypothesized that a low AT is more common among COMISA than among patients with OSA without insomnia. Participants referred for OSA diagnosis underwent a type 3 sleep study and answered the insomnia severity index (ISI) questionnaire and the Epworth sleepiness scale. Participants with an ISI score ≥ 15 were defined as having insomnia. Sleep apnea was defined as an apnea hypopnea index (AHI) ≥ 15 events/h. Low AT was determined using a previously validated score based on 3 polysomnography variables (AHI, nadir SpO2 and the frequency of hypopneas). OSA-only (n = 51) and COMISA (n = 52) participants had similar age (61[52–68] vs 60[53–65] years), body-mass index (31.3[27.7–36.2] vs 32.2[29.5–38.3] kg/m2) and OSA severity (40.2[27.5–60] vs 37.55[27.9–65.2] events/h): all p = NS. OSA-only group had significantly more males than the COMISA group (58% vs 33%, p = 0.013. The proportion of participants with a low AT among OSA-only and COMISA groups was similar (29 vs 33%, p = NS). The similar proportion of low AT among COMISA and patients with OSA suggests that the respiratory arousal threshold may not be related to the increased arousability of insomnia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA)

Yanagimori

Fernandes

Garcia

et al. 2023

Sci Rep

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“…In this study, we calculated the FC between significant differential brain regions and the seed. We evaluated the ability of this FC to identify ID using ROC curves and calculated the areas under curves (AUC) ( Michaud et al, 2021 ; Puzino et al, 2021 ). Furthermore, we compared the ability of FC within the Default Mode Network (DMN) and the biomarker discovered using the Thalamo-cortical seed region to differentiate ID patients.…”

Section: Methodsmentioning

confidence: 99%

The nucleus accumbens functional connectivity in patients with insomnia using resting-state fMRI

Liu

Qin

et al. 2023

Front. Neurosci.

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BackgroundThe aim of this study was to investigate the functional abnormalities between the nucleus accumbens (NAc) and the whole brain in individuals with Insomnia Disorder (ID) using resting-state functional magnetic resonance imaging (fMRI). Additionally, the study aimed to explore the underlying neural mechanisms of ID.MethodsWe enrolled 18 participants with ID and 16 normal controls (NC). Resting-state functional connectivity (FC) between the NAc and the whole brain voxels was calculated and compared between the two groups to identify differential brain region. Receiver operating characteristic (ROC) curve analysis was employed to assess the ability of differential features to distinguish between groups. Furthermore, Pearson correlation analysis was performed to examine the relationship between neurocognitive scores and differential features.ResultsThe ID group exhibited significantly reduced FC values in several brain regions, including the right supplementary motor area, the bilateral middle frontal gyrus, the bilateral median cingulate and paracingulate gyri and the left precuneus. The area under the curve (AUC) of the classification model based on FC in these brain regions was 83.3%. Additionally, the abnormal functional changes observed in ID patients were positively correlated with the Fatigue Severity Scale (R = 0.650, p = 0.004).ConclusionThese findings suggest that the NAc may play a crucial role in the diagnosis of ID and could serve as a potential imaging biomarker, providing insights into the underlying neural mechanisms of the disorder.

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Sleep Reactivity as a Risk Factor for Psychopathology: A Review of Prospective Studies, Mechanisms, and Biological Correlates

Reffi,

Jankowiak,

Iqal

et al. 2024

Curr Sleep Medicine Rep

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Arousability as a trait predisposition to insomnia: multidimensional structure and clinical utility of the Spanish and English versions of the Arousal Predisposition Scale

Cited by 4 publications

References 33 publications

Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA)

Respiratory arousal threshold among patients with isolated sleep apnea and with comorbid insomnia (COMISA)

The nucleus accumbens functional connectivity in patients with insomnia using resting-state fMRI

Sleep Reactivity as a Risk Factor for Psychopathology: A Review of Prospective Studies, Mechanisms, and Biological Correlates

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