Aronia melanocarpa (Michx.) Elliott. attenuates dextran sulfate sodium-induced Inflammatory Bowel Disease via regulation of inflammation-related signaling pathways and modulation of the gut microbiota

Li, Yuting; Tsopmejio, Ivan Stève Nguepi; Diao, Zipeng; Xiao, Huanwei; Wang, Xueqi; Jin, Zhouyu; Song, Hui

doi:10.1016/j.jep.2022.115190

Cited by 8 publications

(4 citation statements)

References 62 publications

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“…An in vivo study showed that the oxidative stress factors and other inflammatory cytokines were attenuated when six-week-old ICR male mice ingested a 3% (w/v) solution of dextran sulfate sodium (DSS) for seven days and were treated orally with an ethanol extract of Aronia berries (100, 300, or 600 mg/kg) plus drinking DSS/water for 29 days. These observations indicate that Aronia berries may possess some therapeutic potential against inflammatory bowel disease [46]. Additionally, an anthocyanin-enriched extract of Aronia berries exhibited anti-inflammatory activity by inhibiting NF-κB [47].…”

Section: Potential Anti-infective Activity Of Aronia Berriesmentioning

confidence: 74%

Potential Benefits of Black Chokeberry (Aronia melanocarpa) Fruits and Their Constituents in Improving Human Health

et al. 2022

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Aronia berry (black chokeberry) is a shrub native to North America, of which the fresh fruits are used in the food industry to produce different types of dietary products. The fruits of Aronia melanocarpa (Aronia berries) have been found to show multiple bioactivities potentially beneficial to human health, including antidiabetic, anti-infective, antineoplastic, antiobesity, and antioxidant activities, as well as heart-, liver-, and neuroprotective effects. Thus far, phenolic compounds, such as anthocyanins, cyanidins, phenolic acids, proanthocyanidins, triterpenoids, and their analogues have been identified as the major active components of Aronia berries. These natural products possess potent antioxidant activity, which contributes to the majority of the other bioactivities observed for Aronia berries. The chemical components and the potential pharmaceutical or health-promoting effects of Aronia berries have been summarized previously. The present review article focuses on the molecular targets of extracts of Aronia berries and the examples of promising lead compounds isolated from these berries, including cyanidin-3-O-galactoside, chlorogenic acid, quercetin, and ursolic acid. In addition, presented herein are clinical trial investigations for Aronia berries and their major components, including cancer clinical trials for chlorogenic acid and COVID-19 trial studies for quercetin. Additionally, the possible development of Aronia berries and their secondary metabolites as potential therapeutic agents is discussed. It is hoped that this contribution will help stimulate future investigations on Aronia berries for the continual improvement of human health.

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Section: Potential Anti-infective Activity Of Aronia Berriesmentioning

confidence: 74%

Potential Benefits of Black Chokeberry (Aronia melanocarpa) Fruits and Their Constituents in Improving Human Health

et al. 2022

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“…These effects can take place in the cells or cytosol by both the direct inhibition of ROS, as demonstrated in the current study, or by activation of antioxidant enzymes (catalase, superoxide dismutase, gluthatione peroxidase) [ 56 , 57 ]. These antioxidant effects likely play a critical role in the anti-inflammatory activity of aronia demonstrated in different animal models [ 19 , 57 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

Cellular Antioxidant Effect of an Aronia Extract and Its Polyphenolic Fractions Enriched in Proanthocyanidins, Phenolic Acids, and Anthocyanins

Dufour¹,

Villa-Rodríguez²,

Furger³

et al. 2022

Antioxidants

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Oxidative stress and chronic inflammation contribute to some chronic diseases. Aronia berries are rich in polyphenols. The aim of the present study was to characterize the cellular antioxidant effect of an aronia extract to reflect the potential physiological in vivo effect. Cellular in vitro assays in three cell lines (Caco-2, HepG2, and SH-SY5Y) were used to measure the antioxidant effect of AE, in three enriched polyphenolic fractions (A1: anthocyanins and phenolic acids; A2: oligomeric proanthocyanidins; A3: polymeric proanthocyanidins), pure polyphenols and microbial metabolites. Both direct (intracellular and membrane radical scavenging, catalase-like effect) and indirect (NRF2/ARE) antioxidant effects were assessed. AE exerted an intracellular free radical scavenging activity in the three cell lines, and A2 and A3 fractions showed a higher effect in HepG2 and Caco-2 cells. AE also exhibited a catalase-like activity, with the A3 fraction having a significant higher activity. Only A1 fraction activated the NRF2/ARE pathway. Quercetin and caffeic acid are the most potent antioxidant polyphenols, whereas cyanidin and 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone showed the highest antioxidant effect among polyphenol metabolites. AE rich in polyphenols possesses broad cellular antioxidant effects, and proanthocyanidins are major contributors. Polyphenol metabolites may contribute to the overall antioxidant effect of such extract in vivo.

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“…Previous studies on experimental animals showed that aronia berry extracts express anti-inflammatory, gastroprotective and neuroprotective activity (16). Aronia berry extracts showed a probiotic effect on intestinal microbiota, and a protective effect against the toxicity of heavy metals and pollutants (17). It was demonstrated that the consumption of aronia fruits lowers the level of triglycerides, total cholesterol and LDL, and reduces the development of cardiovascular diseases (18).…”

Section: Aroniae Fructus Aronia Berry Chokeberrymentioning

confidence: 99%

Antioxidant activity of plant secondary metabolites

Marčetić,

Arsenijević

2023

Arhiv za farmaciju

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Oxidative stress can induce the development of many different disorders. Plant secondary metabolites may act as antioxidants by neutralisation of free radicals and by stimulation of endogenous antioxidant mechanisms. One of the important secondary plant metabolites with antioxidant activity are polyphenols. They can exert activity through different mechanisms depending on their structure. Polyphenols are widely present in herbal drugs, and some of the commonly used ones are aronia berry (Aroniae fructus) and bilberry fruit (Myrtilli fructus), both rich in anthocyanins and tannins and with high antioxidant activity. The main compounds in turmeric rhizome (Curcumae rhizome) are curcuminoides that manifest antioxidant and anti-inflammatory activity. Furthermore, tea leaf (Camelliae sinensis folium) and coffee bean (Coffeae semen), highly present in everyday life, significantly contribute to the daily intake of antioxidants and provide necessary protection of the organism from the consequences of oxidative stress.

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Aronia melanocarpa (Michx.) Elliott. attenuates dextran sulfate sodium-induced Inflammatory Bowel Disease via regulation of inflammation-related signaling pathways and modulation of the gut microbiota

Cited by 8 publications

References 62 publications

Potential Benefits of Black Chokeberry (Aronia melanocarpa) Fruits and Their Constituents in Improving Human Health

Potential Benefits of Black Chokeberry (Aronia melanocarpa) Fruits and Their Constituents in Improving Human Health

Cellular Antioxidant Effect of an Aronia Extract and Its Polyphenolic Fractions Enriched in Proanthocyanidins, Phenolic Acids, and Anthocyanins

Antioxidant activity of plant secondary metabolites

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