Aromatic π-Conjugated Curcumin on Surface Modified Polyaniline/Polyhydroxyalkanoate Based 3D Porous Scaffolds for Tissue Engineering Applications

Abstract

Curcumin-entrapped polyaniline (PAni)-conjugated poly(3hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) electroconductive porous scaffolds were fabricated for application in tissue engineering. The physical and chemical characterizations of the as-prepared biomaterials were performed by UV−vis and ATR/FT-IR spectrophotometric, thermogravimetric, fluorescence microscopic, and X-ray diffractometric analyses. It was observed that compared to the pure PHBV copolymer, which is an insulator, the electroconductivity of the PAni-modified PHBV copolymer increased up to the value of 5.78 × 10 −5 S cm −1 . An antimicrobial study revealed that the curcumin-loaded biomaterials exhibited better bactericidal effect against Grampositive bacterial strains compared to Gram-negative strains. The composite also demonstrated significant compatibility toward blood and fibroblast cells and exhibited the maximum cell viability (90% to 80%). Cell migration and proliferation on the injured tissues were found to occur at a faster rate, resulting in faster repair, in the presence of anti-inflammatory and anticancer curcumin drug loaded composites compared to that of the pure PHBV copolymer.

Nanostructured Polyaniline: An Efficient Support Matrix for Platinum‐Ruthenium Anode Catalyst in Direct Methanol Fuel Cell

“…Polymerization of aniline was performed at the interface of an aqueous layer containing hydrochloric acid (HCl, reagent grade, LobaChemie) and the oxidant ammonium peroxodisulfate (APS, Sigma Aldrich), and an organic layer containing aniline monomer (Sigma Aldrich) . The ratio of the reagent used was aniline:APS:HCl = 1:1:2.…”

Fabrication and characterization of electrospun PLLA/PANI/TSA fibers

“…The SEM images were analyzed using the Image J soware to determine the sizes of the bers. The apparent density and porosity of the electrospun ber mats were calculated using eqn (1) and 2 where, the thickness of the ber mats was measured with a micrometer and the bulk densities of PLA/PANI/TSA2.4 and PLA/PANI/TSA5.3 were 1.274 g cm À3 and 1.272 g cm À3 , respectively, as determined by the hydrostatic weighing method. The resistivity of the PLLA/PANI/TSA slices was measured using an RTS-9 double electric four-probe meter.…”

“…Conducting polymers are widely used in the optoelectronic eld and have recently shown great potential in biomedical applications. [1][2][3] For electroactive scaffold materials, conducting polymers can control the growth and proliferation of tissue cells by electrical stimulation. 4,5 However, it is difficult for an exogenous electromagnetic eld to achieve accurate localization.…”

Physicochemical and Biological Characterisation of Diclofenac Oligomeric Poly(3-hydroxyoctanoate) Hybrids as β-TCP Ceramics Modifiers for Bone Tissue Regeneration

“…In recent years, these compounds were the subject of interest of scientists involved in the production of materials for medical applications [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. Moreover, the attention of many researchers was focused on the chemical modification of PHAs and their copolymers in order to reach a stable chemical bond between the active substance and the matrix of the polymer or oligomer.…”