Aromatic organolithium reagents bearing electrophilic groups. Preparation by halogen-lithium exchange

Sequential metalation of benzene: electronic, bonding, magnetotropic and spectroscopic properties of coinage metalated benzenes studied by DFT

“…Of immense importance is the lithiation of arenes by means of the so-called directed ortho metalation (DoM) method [2]. Since the pioneering work of Gilman [5], several methodologies have been developed to synthesize aryllithium compounds [6][7][8][9][10][11][12][13][14], namely halogen-lithium exchange [11,15], directed lithiation [16][17][18][19][20][21] and direct deprotonation processes [17,[21][22][23]. It should be noted that the lithiation of unsubstituted arenes is normally a very slow process.…”

Probing of the Ligand Anatomy: Effects of the Chelating Alkoxy Ligand Modifications on the Structure and Catalytic Activity of Ruthenium Carbene Complexes

“…The ligand precursor for 6C was obtained by alkylation of 2-propenylphenol with p-nitrobenzyl chloride. 7-Formyl-2,3-dihydrobenzofuran 8E was prepared from 2,6-dibromophenol in a two-step synthesis composed of alkylation with 1,3-dichloropropane and one-pot multistep Parham cyclisation [19] -DMF quenching sequence of 9E according to the previously reported superior procedure. [20] The same conditions were used for the preparation of the 6-membered congener 8F.…”

PdII‐Catalyzed Monoselective ortho Halogenation of CH Bonds Assisted by Counter Cations: A Complementary Method to Directed ortho Lithiation

“…The ortho-diiodinated products were obtained consistently in high yields. These reactions are complementary to directed ortho metalation (DoM) reactions [5] in terms of the observed Yield [a] [%]…”