Aromatic L-amino acid decarboxylases: mechanistic features and microbial applications

Han, Shunsheng; Shin, Jong‐Shik

doi:10.1007/s00253-022-12028-4

Cited by 16 publications

(7 citation statements)

References 103 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, GO and KEGG enrichment analyses revealed the importance of two common DEGs, AADC and AGXT2. AADCs are homologous pyridoxal-5 ′ -phosphate (PLP, active form of vitamin B6)-dependent enzymes that catalyze the conversion of aromatic L-amino acids into aromatic monoamines, mainly including the neurotransmitters dopamine, serotonin, and tyramine [26,27]. The accumulation of neurotransmitters causes overactivation of neurons, leaving the individual in a constant state of excitement, and even has a toxic effect on individual health.…”

Section: Discussionmentioning

confidence: 99%

Preliminary Study on the Pathogenic Mechanism of Jujube Flower Disease in Honeybees (Apis mellifera ligustica) Based on Midgut Transcriptomics

Du,

Xu,

Zhao

et al. 2024

Genes

View full text Add to dashboard Cite

Honeybees are prone to poisoning, also known as jujube flower disease, after collecting nectar from jujube flowers, resulting in the tumultuous demise of foragers. The prevalence of jujube flower disease has become one of the main factors affecting the development of the jujube and beekeeping industries in Northern China. However, the pathogenic mechanisms underlying jujube flower disease in honeybees are poorly understood. Herein, we first conducted morphological observations of the midgut using HE-staining and found that jujube flower disease-affected honeybees displayed midgut damage with peritrophic membrane detachment. Jujube flower disease was found to increase the activity of chitinase and carboxylesterase (CarE) and decrease the activity of superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and the content of CYP450 in the honeybee midgut. Transcriptomic data identified 119 differentially expressed genes in the midgut of diseased and healthy honeybees, including CYP6a13, CYP6a17, CYP304a1, CYP6a14, AADC, and AGXT2, which are associated with oxidoreductase activity and vitamin binding. In summary, collecting jujube flower nectar could reduce antioxidant and detoxification capacities of the honeybee midgut and, in more severe cases, damage the intestinal structure, suggesting that intestinal damage might be the main cause of honeybee death due to jujube nectar. This study provides new insights into the pathogenesis of jujube flower disease in honeybees.

show abstract

Section: Discussionmentioning

confidence: 99%

Preliminary Study on the Pathogenic Mechanism of Jujube Flower Disease in Honeybees (Apis mellifera ligustica) Based on Midgut Transcriptomics

Du,

Xu,

Zhao

et al. 2024

Genes

View full text Add to dashboard Cite

show abstract

“…It was reported that, in mammals, phenylalanine can be metabolized by phenylalanine hydroxylase, and such enzymatic activities were also established in bacteria and lower eukaryote organisms [55]. Additionally, the differences in phenylalanine concentration in non-fermented bovine colostrum can be explained by the possible different effectiveness of its conversion to tyrosine [56] and, in fermented samples, the differences in phenylalanine concentration may be attained due to the distinct activities of microbial decarboxylase, which leads to different phenylalanine conversion to phenylethylamine [57]. -control group samples; -samples fermented with Lp.…”

Section: Phenylalanine Contentmentioning

confidence: 99%

Ascertaining the Influence of Lacto-Fermentation on Changes in Bovine Colostrum Amino and Fatty Acid Profiles

Starkutė,

Mockus,

Klupšaitė

et al. 2023

Animals

View full text Add to dashboard Cite

The aim of this study was to collect samples of bovine colostrum (BCOL) from different sources (agricultural companies A, B, C, D and E) in Lithuania and to ascertain the influence of lacto-fermentation with Lactiplantibacillus plantarum strain 135 and Lacticaseibacillus paracasei strain 244 on the changes in bovine colostrum amino (AA), biogenic amine (BA), and fatty acid (FA) profiles. It was established that the source of the bovine colostrum, the used LAB, and their interaction had significant effects (p < 0.05) on AA contents; lactic acid bacteria (LAB) used for fermentation was a significant factor for aspartic acid, threonine, glycine, alanine, methionine, phenylalanine, lysine, histidine, and tyrosine; and these factor’s interaction is significant on most of the detected AA concentrations. Total BA content showed significant correlations with glutamic acid, serine, aspartic acid, valine, methionine, phenylalanine, histidine, and gamma amino-butyric acid content in bovine colostrum. Despite the differences in individual FA contents in bovine colostrum, significant differences were not found in total saturated (SFA), monounsaturated (MUFA), and polyunsaturated (PUFA) fatty acids. Finally, the utilization of bovine colostrum proved to be challenging because of the variability on its composition. These results suggest that processing bovine colostrum into value-added formulations for human consumption requires the adjustment of its composition since the primary production stage. Consequently, animal rearing should be considered in the employed bovine colostrum processing technologies.

show abstract

“…Phytomelatonin biosynthesis involves four main synthetic routes, all of which require tryptophan as the initial substrate and at least six enzymes, namely tryptophan decarboxylase (TDC), tryptophan hydroxylase (TPH), tryptamine 5-hydroxylase (T5H), serotonin N-acetyltransferase (SNAT), N-acetylserotonin methyltransferase (ASMT), and caffeic-O-methyltransferase (COMT) [8,9]. Among these enzymes, TDC belongs to a group of aromatic-L-amino acid decarboxylases (AADCs), which catalyze the conversion of aromatic L-amino acids to aromatic monoamines and play a crucial role in the synthesis of secondary metabolites in plants [10]. Two important AADCs in plants are TDC and tyrosine decarboxylase (TyrDC) [11], of which TDC uses tryptophan as a substrate, whereas TyrDC uses tyrosine, but both enzymes are involved in the synthesis of various alkaloid metabolites [10,12].…”

Section: Introductionmentioning

confidence: 99%

“…Among these enzymes, TDC belongs to a group of aromatic-L-amino acid decarboxylases (AADCs), which catalyze the conversion of aromatic L-amino acids to aromatic monoamines and play a crucial role in the synthesis of secondary metabolites in plants [10]. Two important AADCs in plants are TDC and tyrosine decarboxylase (TyrDC) [11], of which TDC uses tryptophan as a substrate, whereas TyrDC uses tyrosine, but both enzymes are involved in the synthesis of various alkaloid metabolites [10,12]. Additionally, TDC is responsible for catalyzing the rate-limiting reaction during the synthesis of melatonin.…”

Section: Introductionmentioning

confidence: 99%

The Identification of Cucumber TDC Genes and Analyses of Their Expression and Functions under Abiotic Stress Conditions

Zhang,

Li,

Liu

et al. 2024

Horticulturae

View full text Add to dashboard Cite

Melatonin is a crucial regulator of plant growth and development as well as stress tolerance. However, we only have a limited understanding of the functions of endogenous melatonin. Tryptophan decarboxylase (TDC) serves as the initial rate-limiting enzyme in the melatonin synthesis pathway. To date, no cucumber TDC gene has been cloned and characterized. In this study, we identified two TDC genes (CsTDC1 and CsTDC2) in the cucumber genome. The subcellular localization analysis indicated that CsTDC1 and CsTDC2 are predominantly localized in the cytoplasm and plasma membrane. Tissue-specific expression analyses revealed that CsTDC1 and CsTDC2 are expressed in both vegetative and reproductive organs. Many cis-elements related to stress, hormone, and light responses as well as development were identified in the CsTDC promoter regions. Furthermore, the expression of CsTDC1 and CsTDC2 was strongly induced by treatments with various abiotic stresses and exogenous hormones. The transient overexpression of CsTDC1 and CsTDC2 in tobacco leaves resulted in increases in the TDC activity and melatonin content, along with improved tolerance of tobacco leaves to salt, drought, and low-temperature stresses. Notably, the overexpression of CsTDC2 had a more pronounced effect than the overexpression of CsTDC1. Accordingly, both CsTDC genes, but especially CsTDC2, may be important for regulating cucumber growth, development, and stress tolerance. The study findings provide a theoretical and experimental basis for future functional analyses of endogenous melatonin in cucumber.

show abstract

Aromatic L-amino acid decarboxylases: mechanistic features and microbial applications

Cited by 16 publications

References 103 publications

Preliminary Study on the Pathogenic Mechanism of Jujube Flower Disease in Honeybees (Apis mellifera ligustica) Based on Midgut Transcriptomics

Preliminary Study on the Pathogenic Mechanism of Jujube Flower Disease in Honeybees (Apis mellifera ligustica) Based on Midgut Transcriptomics

Ascertaining the Influence of Lacto-Fermentation on Changes in Bovine Colostrum Amino and Fatty Acid Profiles

The Identification of Cucumber TDC Genes and Analyses of Their Expression and Functions under Abiotic Stress Conditions

Contact Info

Product

Resources

About