Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities

Lu, Shuang-Yang; Peng, Xing‐Rong; Dong, Jin-Run; Yan, Hui; Kong, Qinghua; Shi, Qiang-Qiang; Li, Dashan; Zhou, Lin; Li, Zhongrong; Qiu, Ming‐Hua

doi:10.1016/j.fitote.2019.01.013

Cited by 37 publications

(45 citation statements)

References 35 publications

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“…A newly isolated lanostane triterpene named methyl ganoderate (55) and two known aromatic meroterpenoids, namely, lingzhine E (56) and lingzhine F (57), have been documented to possess neuroprotective activities against H 2 O 2 and aged Aβ-induced cell death in neuroblastoma SHSY5Y cells, an Alzheimerʼs cell model [70]. Two new benzendiols, designated as lucidumins B and C (58,59), along with two new alkaloids, namely, lucidimine E (60) and ganocochlearine A (61), have shown remarkable neuroprotective activity against corticosteroid-induced cytotoxicity in PC12 cells [71]. In patients with depressive disorders, glucocorticoids such as corticosterone and cortisol are secreted at a high level due to the dysfunction and hyperactivity of the hypothalamic-pituitary-adrenal axis, which further leads to damage to hippocampal neurons, followed by depressive symptoms [72][73][74].…”

Section: Ganoderma Lucidummentioning

confidence: 99%

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A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders

Yadav

Jeewon

et al. 2020

Planta Med

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According to the World Health Organization, neurological and neurodegenerative diseases are highly debilitating and pose the greatest threats to public health. Diseases of the nervous system are caused by a particular pathological process that negatively affects the central and peripheral nervous systems. These diseases also lead to the loss of neuronal cell function, which causes alterations in the nervous system structure, resulting in the degeneration or death of nerve cells throughout the body. This causes problems with movement (ataxia) and mental dysfunction (dementia), both of which are commonly observed symptoms in Alzheimerʼs disease, Parkinsonʼs disease, Huntingtonʼs disease, and multiple sclerosis. Medicinal mushrooms are higher fungi with nutraceutical properties and are low in calories and fat. They are also a rich source of nutrients and bioactive compounds such as carbohydrates, proteins, fibers, and vitamins that have been used in the treatment of many ailments. Medicinal mushrooms such as Pleurotus giganteus, Ganoderma lucidium, and Hericium erinaceus are commonly produced worldwide for use as health supplements and medicine. Medicinal mushrooms and their extracts have a large number of bioactive compounds, such as polysaccharide β-glucan, or polysaccharide-protein complexes, like lectins, lactones, terpenoids, alkaloids, antibiotics, and metal-chelating agents. This review will focus on the role of the medicinal properties of different medicinal mushrooms that contain bioactive compounds with a protective effect against neuronal dysfunction. This information will facilitate the development of drugs against neurodegenerative diseases.

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Section: Ganoderma Lucidummentioning

confidence: 99%

“…Pers. have also been traditionally used to improve memory and health in China [71]. Earlier studies have reported that Hericium has numerous bioactive compounds that have various strong activities, such as neuroprotective anti-(neuro)-inflammatory, antioxidant, immunomodulatory, and antiaging activities [76][77][78][79].…”

Section: Hericium Erinaceusmentioning

confidence: 99%

A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders

Yadav

Jeewon

et al. 2020

Planta Med

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“…Однако, при окислительном стрессе видоизмененные Toll-рецепторы не могут самостоятельно распознавать микробные агенты за счет измененной химической формулы L-глюкозозамина и таким образом активации медиаторов не происходит. В настоящее время ведутся научные споры по поводу HMGB1 белка, так как в недавних исследованиях было показано, что данный белок регулирует деятельность Toll-подобных рецепторов через сигнальные пути и по принципу обратной связи активирует и видоизменяет Toll-рецепторы [4,5]. Но, чтобы HMGB 1 белок выделился, необходимы условия, при которых данный белок связывается через лиганды к Toll-подобным рецепторам.…”

Section: актуальностьunclassified

Prognostic Value of the Use of Ganoderma Lucidum Under Conditions of Oxidative Stress

Irsikulov¹,

Abilov²

2020

Medicina

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“…Ganoderma lucidum (Ling Zhi (in China) or Reishi (in Japan)), also known as “the fungus of immortality”, is recognized among most important traditional medicinal mushrooms and most powerful adaptogens present in nature, since it acts as a regulator of biological functions [ 1 , 2 , 3 ]. The pharmacological properties of G. lucidum , such as anti-inflammatory, antioxidant, antiaging, immunomodulatory and antitumour activities [ 4 , 5 , 6 , 7 ], are due to its peculiar chemical composition in bioactive compounds such as polysaccharides, terpenoids, nucleotides, steroids, fatty acids, proteins and glycopeptides [ 8 , 9 ]. Based on that, G. lucidum was also reported to act as an adjuvant in the treatment of several diseases, i.e., anorexia, hypertension, insomnia and chronic hepatitis [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury

et al. 2020

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Ganoderma lucidum or Reishi is recognized as the most potent adaptogen present in nature, and its anti-inflammatory, antioxidant, immunomodulatory and anticancer activities are well known. Moreover, lately, there has been an increasing interest from pharmaceutical companies in antiaging G. lucidum-extract-based formulations. Nevertheless, the pharmacological mechanisms of such adaptogenic and regenerative actions remain unclear. The present investigation aimed to explore its molecular and cellular effects in vitro in epidermal keratinocyte cultures by applying liquid chromatography coupled to ion trap time-of-flight mass spectrometry (LCMS-IT-TOF) for analysis of ethanol extracts using ganoderic acid-A as a reference compound. The G. lucidum extract showed a keratinocyte proliferation induction accompanied by an increase of cyclic kinase protein expressions, such as CDK2 and CDK6. Furthermore, a noteworthy migration rate increase and activation of tissue remodelling factors, such as matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9), were observed. Finally, the extract showed an antioxidant effect, protecting from H2O2-induced cytotoxicity; preventing activation of AKT (protein kinase B), ERK (extracellular signal-regulated kinase), p53 and p21; and reducing the number of apoptotic cells. Our study paves the path for elucidating pharmacological properties of G. lucidum and its potential development as cosmeceutical skin products, providing the first evidence of its capability to accelerate the healing processes enhancing re-epithelialization and to protect cells from free-radical action.

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Aromatic constituents from Ganoderma lucidum and their neuroprotective and anti-inflammatory activities

Cited by 37 publications

References 35 publications

A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders

A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders

Prognostic Value of the Use of Ganoderma Lucidum Under Conditions of Oxidative Stress

Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury

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