“…This gap warrants exploration of sex-based gut microbiome treatments for a tailored precision medicine approach. Additionally, nonpharmacological methods such as transcranial pulse stimulation, aromatherapy, psychosocial interventions, social interventions, and music interventions, among others ( Dhippayom et al, 2022 ; Bavarsad et al, 2023 ; Chen X. et al, 2023 ; McAleer et al, 2023 ; Tan et al, 2023 ; Vuijk et al, 2023 ), hold significant promise as strategies to enhance the management of depression and AD. Moving forward, the development of a precision medicine framework, integrating knowledge gained from sex-related distinctions, could transform the future management of AD and depression, ultimately contributing to substantial improvements in the quality of life for almost all patients.…”