Aromatherapy for the brain: Lavender's healing effect on epilepsy, depression, anxiety, migraine, and Alzheimer's disease: A review article

Bavarsad, Neda; Bagheri, Shokufeh; Kourosh-Arami, Masoumeh; Komaki‬, Alireza

doi:10.1016/j.heliyon.2023.e18492

Cited by 5 publications

(2 citation statements)

References 135 publications

(162 reference statements)

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“…This gap warrants exploration of sex-based gut microbiome treatments for a tailored precision medicine approach. Additionally, nonpharmacological methods such as transcranial pulse stimulation, aromatherapy, psychosocial interventions, social interventions, and music interventions, among others ( Dhippayom et al, 2022 ; Bavarsad et al, 2023 ; Chen X. et al, 2023 ; McAleer et al, 2023 ; Tan et al, 2023 ; Vuijk et al, 2023 ), hold significant promise as strategies to enhance the management of depression and AD. Moving forward, the development of a precision medicine framework, integrating knowledge gained from sex-related distinctions, could transform the future management of AD and depression, ultimately contributing to substantial improvements in the quality of life for almost all patients.…”

Section: Discussionmentioning

confidence: 99%

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Chen,

Wang,

Liu

et al. 2024

Front. Aging Neurosci.

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Depression and Alzheimer’s disease (AD) are prevalent neuropsychiatric disorders with intriguing epidemiological overlaps. Their interrelation has recently garnered widespread attention. Empirical evidence indicates that depressive disorders significantly contribute to AD risk, and approximately a quarter of AD patients have comorbid major depressive disorder, which underscores the bidirectional link between AD and depression. A growing body of evidence substantiates pervasive sex differences in both AD and depression: both conditions exhibit a higher incidence among women than among men. However, the available literature on this topic is somewhat fragmented, with no comprehensive review that delineates sex disparities in the depression–AD correlation. In this review, we bridge these gaps by summarizing recent progress in understanding sex-based differences in mechanisms, genetics, and therapeutic prospects for depression and AD. Additionally, we outline key challenges in the field, holding potential for improving treatment precision and efficacy tailored to male and female patients’ distinct needs.

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Section: Discussionmentioning

confidence: 99%

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Chen,

Wang,

Liu

et al. 2024

Front. Aging Neurosci.

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“…In the current study, the basic formula (F1) containing equal weights of labrafac lipophile and Kolliphor HS15 (500 mg) in the ratio 1:3 w/w to deionized water was selected based on previous reports [20,59]. The oily core was modified by inclusion of lavender essential oil (LAV) due to its well reported anticonvulsant effect [60]. LAV was incorporated into the LNC formulation in different Labrafac: LAV ratios (3:1, 2:1 and 1:2).…”

Section: Preparation Of Lncmentioning

confidence: 99%

Brain targeted lactoferrin coated lipid nanocapsules for the combined effects of apocynin and lavender essential oil in PTZ induced seizures

Youssef,

Boraie,

Ismail

et al. 2024

Drug Deliv. and Transl. Res.

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Apocynin (APO) is a plant derived antioxidant exerting specific NADPH oxidase inhibitory action substantiating its neuroprotective effects in various CNS disorders, including epilepsy. Due to rapid elimination and poor bioavailability, treatment with APO is challenging. Correspondingly, novel APO-loaded lipid nanocapsules (APO-LNC) were formulated and coated with lactoferrin (LF-APO-LNC) to improve br ain targetability and prolong residence time. Lavender oil (LAV) was incorporated into LNC as a bioactive ingredient to act synergistically with APO in alleviating pentylenetetrazol (PTZ)-induced seizures. The optimized LF-APO-LAV/LNC showed a particle size 59.7 ± 4.5 nm with narrow distribution and 6.07 ± 1.6mV zeta potential) with high entrapment efficiency 92 ± 2.4% and sustained release (35% in 72 h). Following subcutaneous administration, LF-APO-LAV/LNC brought about ⁓twofold increase in plasma AUC and MRT compared to APO. A Log BB value of 0.2 ± 0.14 at 90 min reflects increased brain accumulation. In a PTZ-induced seizures rat model, LF-APO-LAV/LNC showed a Modified Racine score of 0.67 ± 0.47 with a significant increase in seizures latency and decrease in duration. Moreover, oxidant/antioxidant capacity and inflammatory markers levels in brain tissue were significantly improved. Histopathological and immunohistochemical assessment of brain tissue sections further supported these findings. The results suggest APO/LAV combination in LF-coated LNC as a promising approach to counteract seizures. Graphical Abstract

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Traditional Chinese medicine: Its growing potential in treating neurological disorders

Bhushan,

Singh,

Singh

2024

Pharmacological Research - Modern Chinese Medicine

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Aromatherapy for the brain: Lavender's healing effect on epilepsy, depression, anxiety, migraine, and Alzheimer's disease: A review article

Cited by 5 publications

References 135 publications

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Sex differences in the relationship between depression and Alzheimer’s disease—mechanisms, genetics, and therapeutic opportunities

Brain targeted lactoferrin coated lipid nanocapsules for the combined effects of apocynin and lavender essential oil in PTZ induced seizures

Traditional Chinese medicine: Its growing potential in treating neurological disorders

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