Aromatherapy and Aromatic Plants for the Treatment of Behavioural and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: Clinical Evidence and Possible Mechanisms

Scuteri, Damiana; Morrone, Luigi Antonio; Rombolà, Laura; Avato, Pina Rosa; Bilia, Anna Rita; Corasaniti, Maria Tiziana; Sakurada, Shinobu; Sakurada, Tsukasa; Bagetta, Giacinto

doi:10.1155/2017/9416305

Cited by 43 publications

(29 citation statements)

References 58 publications

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“…About 12 medicinal plants amounting to 28% were administered in the form of incense or steam inhalation; this suggests that the volatile principle in the plant was required. Volatile oils are widely used in aromatherapy to manage many health conditions and clinical trials using aromatherapy as a method of managing anxiety and sleep related disorders under complementary and alternative medicine has been reported (Scuteri et al, 2017).…”

Section: Dosage Forms and The Routes Of Administrationmentioning

confidence: 99%

Ethnobotanical survey of plants used in the management of mental illnesses in some selected local government areas of Plateau State, Nigeria

Ior¹,

Otimenyin²,

Okwori³

et al. 2017

J. Pharmacognosy Phytother.

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Mental illness refers to all diagnosable mental disorders which are characterised by abnormalities in thinking, feelings or behaviours. Ethnobotanical study surveyed the different types of medicinal plants used for the treatment of mental illness in Bassa, Pankshin, and Kanke Local Government Areas of Plateau State, Nigeria. Information was obtained from traditional medicine practitioners, herbalist and herb sellers, with the aid of semi structured questionnaire. Plant samples were collected and identified by taxonomists in the herbarium section of Federal College of Forestry Jos and Ahmadu Bello University Zaria, Nigeria. The information was obtained from a total of 35 respondents. Forty two plants were identified from the study, from 31 families. The source, uses, plant parts, and methods of preparation were some of the information derived. The family with the highest number of represented species was Lamiaceae accounting for 10% with a user value of 0.035. The dominant route of administration employed for drug delivery was oral accounting for up to 80% (56% as strictly oral). The plant parts mostly collected by the respondents for management of the conditions reported are leaves amounting to 51%. Some of the plants have recorded scientific values for neuropharmacological activities, whereas others are yet to be tested. It is important to validate these plants scientifically for possible neuropharmacological properties that may be harnessed for future use.

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Section: Dosage Forms and The Routes Of Administrationmentioning

confidence: 99%

Ethnobotanical survey of plants used in the management of mental illnesses in some selected local government areas of Plateau State, Nigeria

Ior¹,

Otimenyin²,

Okwori³

et al. 2017

J. Pharmacognosy Phytother.

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“…Likewise, in a study discussing the phytochemical mechanisms of aromatherapeutic oils for the treatment of behavioral and psychological symptoms in patients suffering from dementia, the authors call for more rigorous research. However, this conclusion is made without providing a sound definition of what constitutes aromatherapy (Scuteri et al, ). Finally, in a recent systematic review and meta‐analysis exploring the effects of aromatherapy on the treatment of psychological symptoms in postmenopausal women (Babakhanian et al, ), the authors are caught in the conceptual trap that has made aromatherapy a somewhat dubious intervention by confusing the very functional mechanisms they wish to investigate.…”

Section: Introductionmentioning

confidence: 99%

Medical aromatherapy revisited—Basic mechanisms, critique, and a new development

Schneider¹,

Singer²,

Singer³

2018

Human Psychopharmacology

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Objective According to a series of recent meta‐analyses and systematic reviews, aromatherapy has shown to be effective in treating patients with different medical conditions. However, many of the clinical studies are of rather low methodological quality. Moreover, there is much conceptual ambiguity with regard to what aromatherapy actually constitutes. Method In this paper, we discuss the conditions under which aromatherapy is most likely to be of medical value by outlining the workings of the olfactory system and the necessary requirements of odors to be therapeutic. We then introduce an aromatherapeutic inhaler that was tested in a series of studies involving 465 participants. Results This inhaler (AromaStick®) produced large to very large effects across a variety of physiological target systems (e.g., cardiovascular, endocrine, blood oxygenation, and pain), both short term and long term. Discussion Inhalation of volatile compounds from essential oils yields almost immediate, large, and clinically relevant effects as long as the scents are delivered highly concentrated from an appropriate device. The changes caused in the body seem side effect‐free and can be sustained when inhalation is repeated.

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“…Medicinal plant extracts, useful for different therapeutic purposes, e.g., aromatherapy in dementia [165][166][167][168], may influence the pharmacokinetics of co-administered drugs then inducing modifications in plasma drug levels. Consequently, it may not reach a therapeutic response or, alternatively, it may cause drug-induced toxicity.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic Interactions between Herbal Medicines and Drugs: Their Mechanisms and Clinical Relevance

Rombolà

Scuteri

Straface

et al. 2020

Life

Self Cite

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The therapeutic efficacy of a drug or its unexpected unwanted side effects may depend on the concurrent use of a medicinal plant. In particular, constituents in the medicinal plant extracts may influence drug bioavailability, metabolism and half-life, leading to drug toxicity or failure to obtain a therapeutic response. This narrative review focuses on clinical studies improving knowledge on the ability of selected herbal medicines to influence the pharmacokinetics of co-administered drugs. Moreover, in vitro studies are useful to anticipate potential herbal medicine-drug interactions. In particular, they help to elucidate the cellular target (metabolic or transporter protein) and the mechanism (induction or inhibition) by which a single constituent of the herbal medicine acts. The authors highlight the difficulties in predicting herbal–drug interactions from in vitro data where high concentrations of extracts or their constituents are used and pharmacokinetics are missed. Moreover, the difficulty to compare results from human studies where different kinds of herbal extracts are used is discussed. The herbal medicines discussed are among the best sellers and they are reported in the “Herbal Medicines for Human Use” section of the European Medicinal Agency (EMA).

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Aromatherapy and Aromatic Plants for the Treatment of Behavioural and Psychological Symptoms of Dementia in Patients with Alzheimer’s Disease: Clinical Evidence and Possible Mechanisms

Cited by 43 publications

References 58 publications

Ethnobotanical survey of plants used in the management of mental illnesses in some selected local government areas of Plateau State, Nigeria

Ethnobotanical survey of plants used in the management of mental illnesses in some selected local government areas of Plateau State, Nigeria

Medical aromatherapy revisited—Basic mechanisms, critique, and a new development

Pharmacokinetic Interactions between Herbal Medicines and Drugs: Their Mechanisms and Clinical Relevance

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