Aromatherapy alleviates endothelial dysfunction of medical staff after night-shift work: preliminary observations

Shimada, Kenei; Fukuda, Shota; Maeda, Kumiko; Kawasaki, Toshihiro; Kono, Yasushi; Jissho, Satoshi; Taguchi, Haruyuki; Yoshiyama, Minoru; Yoshikawa, Junichi

doi:10.1038/hr.2010.228

Cited by 19 publications

(12 citation statements)

References 27 publications

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“…Amir et al 29 found a relevant FMD reduction after a WN, compared to a RN (from 10.5 AE 4.5% to 6.7 AE 4.8%) in 30 physicians, and a similar significant FMD reduction (from 12.5 AE 1.7% to 10.4 AE 1.8%, p < 0.001) was also found by Shimada et al 30 in 19 healthy medical personnel (11 physicians, eight technicians).…”

Section: Discussionsupporting

confidence: 80%

Effect of shift work on endothelial function in young cardiology trainees

Tarzia

Milo

Monaco

et al. 2011

Eur J Prev Cardiolog

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Section: Discussionsupporting

confidence: 80%

Effect of shift work on endothelial function in young cardiology trainees

Tarzia

Milo

Monaco

et al. 2011

Eur J Prev Cardiolog

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“…Flow-mediated brachial artery dilatation was lower in medical staff after nightshift work (average sleeping time of 3.3 h) than on a regular workday, which was improved after aromatherapy (30 min by inhalation of the essential oil of lavender) [104].…”

Section: Aromatherapy and Acupuncturementioning

confidence: 99%

How mental stress affects endothelial function

Toda¹,

Nakanishi-Toda

2011

Pflugers Arch - Eur J Physiol

110

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Mental stress is an important factor contributing to recognized mechanisms underlying cardiovascular events. Among these, stress-related endothelial dysfunction is an early risk factor that predicts future development of severe cardiovascular disorders. Acute mental stress by a variety of tests impairs endothelial function in humans, although the opposite results have been reported by some investigators. Chronic stress always deteriorates endothelial function in humans and experimental animals. Stress hormones, such as glucocorticoids and pro-inflammatory cytokines, and endothelin-1 liberated in response to mental stress participate in endothelial dysfunction possibly via downregulation of endothelial nitric oxide synthase (eNOS) expression, eNOS inactivation, decreased nitric oxide (NO) actions, and increased NO degradation, together with vasoconstriction counteracting against NO-induced vasodilatation. Catecholamines do not directly affect endothelial function but impair its function when blood pressure elevation by the amines is sustained. Endogenous opioids favorably affect endothelial function, which counteract deteriorating effects of other stress hormones and mediators. Inhibition of cortisol and endothelin-1 production, prevention of pro-inflammatory mediator accumulation, hypnotics, mirthful laughter, humor orientation, and lifestyle modification would contribute to the prevention and treatment for stress-related endothelial dysfunction and future serious cardiovascular disease.

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“…FMD of the brachial artery is a widely used method for the study of endothelial function in clinical practice 15–17. However, this method requires a certain degree of skill to obtain accurate measurements of brachial artery diameter.…”

Section: Discussionmentioning

confidence: 99%

Very rapid effect of pitavastatin on microvascular function in comparison to rosuvastatin: reactive hyperemia peripheral arterial tonometric study

Kono¹,

Fukuda²,

Shimada³

et al. 2013

DDDT

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Background:It has been reported that pitavastatin improves endothelial function faster than other statins. Recently introduced reactive hyperemia peripheral arterial tonometry (RH-PAT) provides objective and quantitative assessment of peripheral microvascular function.Purpose:This study aimed to investigate whether peripheral microvascular function improved 2 hours after pitavastatin in subjects with coronary artery disease (CAD) using RH-PAT, and the results were compared with those of rosuvastatin.Methods:This study included 94 subjects with CAD, assigned to a group given 2 mg of pitavastatin (n = 36), a group given 2.5 mg of rosuvastatin (n = 38), and a control group (n = 20). RH-PAT examinations were performed before and 2 hours after statin administration.Results:The RH-PAT index increased 2 hours after pitavastatin administration from 1.82 ± 0.45 to 2.16 ± 0.62 (P = 0.02), whereas there were no differences in the RH-PAT index in the rosuvastatin group (1.79 ± 0.71 to 1.91 ± 0.53, P = 0.09) and the control group (1.68 ± 0.36 to 1.84 ± 0.58, P = 0.4). No significant changes were observed at 2 hours in serum cholesterol levels in each group.Conclusion:The present study demonstrated that peripheral microvascular function improved 2 hours after a single clinical dose of pitavastatin, but not after rosuvastatin.

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Aromatherapy alleviates endothelial dysfunction of medical staff after night-shift work: preliminary observations

Cited by 19 publications

References 27 publications

Effect of shift work on endothelial function in young cardiology trainees

Effect of shift work on endothelial function in young cardiology trainees

How mental stress affects endothelial function

Very rapid effect of pitavastatin on microvascular function in comparison to rosuvastatin: reactive hyperemia peripheral arterial tonometric study

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