Aroclor 1254-induced cytotoxicity in catecholaminergic CATH.a cells related to the inhibition of NO production

Effect of Cadmium Contaminated Diet in Controlling Water Behavior by Meriones shawi

“…According to these authors, the AVP decline was attributable to specific effects of overt toxicity and/or malaise oral of PCBs on vasopressinergic hypothalamic cells function. In combination with the efficacy of in vitro application, these data are consistent with direct actions on components of the hypothalamo-neurohypophysial system present within the SON [67][68]. PCBs has been reported to inhibit nitric oxide synthase activity.…”

Involvement of Na+-Ca2+Exchanger in Intracellular Ca2+Increase and Neuronal Injury Induced by Polychlorinated Biphenyls in Human Neuroblastoma SH-SY5Y Cells

“…In fact, both bepridil and KB-R7943, at the same concentrations that inhibited [Ca 2ϩ ] i increase, caused a significant reduction of cell injury elicited by A1254 and, in cells transfected with antisense NCX1 ODN, the extent of cell damage induced by the PCB mixture was significantly lower than that observed in naive cells. On the other hand, it is well known that an increase of [Ca 2ϩ ] i can trigger intracellular pathways leading to cell death (Kristian and Siesjo, 1998;Kang et al, 2002Kang et al, , 2004. It is noteworthy that cell protection from A1254-elicited injury obtained by the inhibition of NCX was not complete, exactly as the reduction of A1254-elicited [Ca 2ϩ ] i increase.…”

Involvement of the nitric oxide/protein kinase G pathway in polychlorinated biphenyl‐induced cell death in SH‐SY 5Y neuroblastoma cells

“…In this regard it can be hypothesized that the inhibitory regulation of nNOS exerted by A1254 and responsible for dopaminergic neurotoxicity may occur at the level of nNOSa. Indeed, the decreased expression described by Kang et al (2002) has been observed at the level of 160-kDa nNOS protein that corresponds to the a isoform. In addition, Sharma and Kodavanti (2002) have shown that in vitro activity of cytosolic and membrane NOS in selected brain regions can be reduced by exposure to di-ortho-PCB.…”

“…It should be mentioned that earlier studies by Kang et al (2002) suggest that A1254-induced dopaminergic neurotoxicity is partially dependent on the inhibition of nNOS expression. In this regard it can be hypothesized that the inhibitory regulation of nNOS exerted by A1254 and responsible for dopaminergic neurotoxicity may occur at the level of nNOSa.…”