Armoring a liposome-integrated tissue factor with sacrificial CaCO<sub>3</sub> to form potent self-propelled hemostats

Liu, ChengKun; Shi, Zhuang; Zhu, Jianming; Liu, Chang; Liu, Xiaodan; Khan, Naseer Ullah; Liu, Shihai; Wang, Xiaojuan; Wang, Xiaoqiang; Huang, Fang

doi:10.1039/d2tb02140d

Cited by 6 publications

(1 citation statement)

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“…The hemocompatibility of multilayer alginate hydrogels, along with their procoagulant activity, was further investigated in vitro with rabbit whole blood. According to the international evaluation standard, a hemolytic effect is defined as a material-induced hemolysis ratio greater than 5% compared to deionized water-treated RBCs, which typically experience complete lysis . The hemolysis ratios for ACP, ACC, and AC were similar and all at least 40-fold lower than 5% (Figure A), indicating good blood compatibility.…”

Section: Resultsmentioning

confidence: 99%

Barnacle-Inspired Integration of Alginate Multilayer Hydrogels Via Calcium Mineralization

Liu,

Li,

Liu

et al. 2024

ACS Sustainable Chem. Eng.

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Multilayered hydrogels with an organization of distinct functional layers have emerged as the preferred materials for biomedical applications. Taking inspiration from the symbiotic integration of cement proteins and calcified base plates observed in barnacles, we present here an eco-friendly spray-aided approach for creating multilayered alginate/mineral hybrid hydrogels through Ca 2+ -induced alginate gelation and concurrent mineralization. Electron microscopy, X-ray photoelectron spectroscopy, and X-ray diffraction analyses confirmed the formation of thin films of CaCO 3 or Ca 3 (PO 4 ) 2 between the alginate interlayers. Incorporation of calcium minerals was shown to improve considerably the physical properties of alginate multilayer hydrogels, including elasticity and its temperature-responsiveness, porosity, swelling, and liposome release capability (as a drug release model). Moreover, comprehensive in vitro and in vivo evaluations using NIH-3T3 cells, a rat model, and rabbit whole blood demonstrated good biocompatibility and procoagulant activity of the alginate/mineral multilayer hydrogels. Notably, the integration of Ca 3 (PO 4 ) 2 with an alginate multilayer outperformed CaCO 3 in all aforementioned physical and procoagulant properties. Hence, the combination of mineralization (especially Ca 3 (PO 4 ) 2 ) with alginate multilayer structuring exhibits significant potential for various healthcare applications. This biomimetic green strategy can also be adapted readily for the sustainable fabrication of other organic−inorganic multilayers with alginate-like polyanionic polymers and calcium minerals.

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Section: Resultsmentioning

confidence: 99%

Barnacle-Inspired Integration of Alginate Multilayer Hydrogels Via Calcium Mineralization

Liu,

Li,

Liu

et al. 2024

ACS Sustainable Chem. Eng.

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Trojan-horse mineralization of trigger factor to impregnate non-woven alginate fabrics for enhanced hemostatic efficacy

Liu

Shi

et al. 2023

Carbohydrate Polymers

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A peptide-engineered alginate aerogel with synergistic blood-absorbing and platelet-binding capabilities to rapidly stop bleeding

Liu

Shi

et al. 2023

Carbohydrate Polymers

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Armoring a liposome-integrated tissue factor with sacrificial CaCO₃ to form potent self-propelled hemostats

Abstract: The development of hemostatic materials suitable for varied emergency scenarios is of paramount significance, and there is an increasing interest in the wound-site delivery of hemostasis-augmenting agents that can leverage...

Cited by 6 publications

References 47 publications

Barnacle-Inspired Integration of Alginate Multilayer Hydrogels Via Calcium Mineralization

Barnacle-Inspired Integration of Alginate Multilayer Hydrogels Via Calcium Mineralization

Trojan-horse mineralization of trigger factor to impregnate non-woven alginate fabrics for enhanced hemostatic efficacy

A peptide-engineered alginate aerogel with synergistic blood-absorbing and platelet-binding capabilities to rapidly stop bleeding

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Armoring a liposome-integrated tissue factor with sacrificial CaCO3 to form potent self-propelled hemostats

Abstract: The development of hemostatic materials suitable for varied emergency scenarios is of paramount significance, and there is an increasing interest in the wound-site delivery of hemostasis-augmenting agents that can leverage...

Cited by 6 publications

References 47 publications

Barnacle-Inspired Integration of Alginate Multilayer Hydrogels Via Calcium Mineralization

Barnacle-Inspired Integration of Alginate Multilayer Hydrogels Via Calcium Mineralization

Trojan-horse mineralization of trigger factor to impregnate non-woven alginate fabrics for enhanced hemostatic efficacy

A peptide-engineered alginate aerogel with synergistic blood-absorbing and platelet-binding capabilities to rapidly stop bleeding

Contact Info

Product

Resources

About

Armoring a liposome-integrated tissue factor with sacrificial CaCO₃ to form potent self-propelled hemostats