Armodafinil for fatigue associated with menopause

Meyer, F.J.; Freeman, Marlene P.; Petrillo, Laura; Barsky, Maria; Galvan, Thania; Kim, Semmie; Cohen, Lee S.; Joffe, Hadine

doi:10.1097/gme.0000000000000505

Cited by 6 publications

(10 citation statements)

References 30 publications

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“…The MENQOL scale contains 29 items, which explore the experience of different menopausal symptoms as endorsed or not endorsed as well as the degree of being bothered by symptoms on a scale that ranges from 0 (not at all bothered) to 6 (extremely bothered). Symptoms assessed by the MENQOL are distinguished into four domains: vasomotor (items 1-3), psychosocial (items 4-10), physical (items [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26], and sexual (items 27-29) [9,42]. The questionnaire was translated into Arabic by a professional translator.…”

Section: Study Instrumentsmentioning

confidence: 99%

“…Menopausal symptoms such as lack of energy and fatigue, experienced by 43.9-64.7% of menopausal women, are strongly associated with exhaustion and burnout, which may seriously compromise quality of life of affected women [22][23][24]. Fatigue is described as a feeling of lack of energy, weariness, loss of drive, decrease or loss of ability to sustain even routine activities, overwhelming feeling of tiredness, exhaustion, and physical or mental strain that occurs even without conspicuous effort.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, dysregulation of the hypothalamic-pituitary-adrenal axis and persistent activation of the sympathetic nervous system are common in people with chronic fatigue syndrome, and they trigger a wide range of symptoms that can induce excessive suffering [5,26]. Studies on menopause-specific fatigue, fatigue explained mainly by endorsing menopause transition rather than suffering insomnia or depression, are relatively scarce [23]. However, evidence denotes strong connections between menopausal fatigue and emotional negativity (depressed mood and perceived stress) during menopause [27].…”

Section: Introductionmentioning

confidence: 99%

“…Hence, working menopausal women may require specific interventions that promote processes of energy recovery [22]. Research shows that menopause-specific fatigue can be alleviated by pharmacologic treatments (e.g., armodafinil, a wakefulness-promoting agent and a central nervous system stimulant) and non-pharmacologic interventions such as hypnosis [23,29].…”

Section: Introductionmentioning

confidence: 99%

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Psychological Climacteric Symptoms and Attitudes toward Menopause among Emirati Women

Ali

Ahmed

Smail

2020

IJERPH

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Menopause is an inevitable developmental event that women encounter at an age of 42–54 years. The drop of estrogen levels that accompanies cessation of menstruation is associated with multiple vasomotor, physical, neuropsychological, and sexual symptoms, which may hamper quality of life. This study aimed to examine the severity of psychological symptoms and their correlates among peri- and postmenopausal Emirati women (N = 60, mean age = 54.88 ± 6 years). Participants were interviewed using the Menopause-Specific Quality of Life (MENQOL) and attitudes toward menopause scale (ATMS). In four path analysis models, vasomotor symptoms, weight gain, and fatigue had significant direct effects on symptoms of anxiety, depression (only weight gain and fatigue), and psychological distress. Fatigue significantly mediated the effects of vasomotor symptoms and weight gain on symptoms of anxiety, depression (only vasomotor symptoms), psychological distress, and memory problems. These models explained 47.6%, 44.5%, 56.6%, and 29.1% of the variances in anxiety, depression, psychological distress, and memory problems, respectively. Participants with more severe menopausal symptoms expressed more negative attitudes toward menopause though regression analysis revealed that only vasomotor symptoms could significantly contribute to ATMS scores. In conclusion, psychological distress is widespread among menopausal women, and it is associated with vasomotor symptoms, fatigue, and change of body composition (obesity). Psychological symptoms, along with vasomotor symptoms, express a key link to negative attitudes toward menopause. Therefore, interventional strategies that target psychological distress may promote coping with midlife transition and improve mental health among menopausal women.

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Section: Study Instrumentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psychological Climacteric Symptoms and Attitudes toward Menopause among Emirati Women

Ali

Ahmed

Smail

2020

IJERPH

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“…В многоцентровом исследовании женщин с КД десвенлафаксин (150 мг/д) в негормональной терапии климакса снижал (p < 0,001) депрессивное настроение, подавленность, печаль, беспокойство, тревогу [42]. Четырехнедельная терапия армодафинилом (150 мг/д) [43] повышала показатели по Menopause Specific Quality Life (р = 0,0001): вазомоторных симптомов и когнитивной функции, подавленности, печали, плаксивости, анергии, колебаний настроения, усталости. Вызывает сомнение превосходство гомеопатии над флуоксетином и плацебо в рандомизированном исследовании антидепрессивной терапии у мексиканских женщин [44].…”

Section: фармакотерапия при кдunclassified

Depressive disorders in women of climacteric age (review of foreign literature for 2012–2016)

Бохан¹,

Лукьянова²,

Симуткин³

2018

Bûll. sib. med.

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Objective:to systematically review foreign literature and interpret results of the review. Tasks: to review foreign papers where factors are considered which provoke development of depression: hormonal, psychological, social as well as neuromediators, hormonal and immune disturbances in depressive disorders in women with physiological climacteric and climacteric syndrome; issues of differential diagnostics of depressions, psychopharmaco- and psychotherapy with subsequent evaluation of clinical efficiency; personality profile of pateints with affective psychopathology.Methods of search: by keywords in Web of Science Core Collection database across foreign journals (2012– 2016). Criteria of inclusion of papers in the review are determined by themes of studies: 1) women of climacteric age; 2) presence of depression or depressive symptoms; 3) presence of climacteric disturbances. In the abstract-bibliographic and scientometric database Web of Science Core Collection 70 bibliographic sources are selected across foreign journals between 2012 and 2016, including journals with high Impact Factor. Studies included in the review are performed at the university clinics, specialized centers. Clinical and sociodemographic characteristics of female patients meet the criterion of compatibility. Most discussed papers are devoted to study of clinical and social-psychological factors of development of climacteric depression. In a number of papers the efficiency of antidepressant therapy, alternative methods and supplementary therapy in women with depressive disorders, climacteric disturbances and co-occurring physical diseases is shown. Most works are performed with involvement of questionnaires (sociodemographic data, anamnesis) and international clinical scales. The main results of the discussed papers are outlined in thematic rubrics.Conclusion. The European and American papers are used in this review more frequently; studies from Asian countries are used more seldom. Reviewed foreign publications reflect worldwide trend to increase of climacteric depression (CD) in the female population with presence in the anamnesis of adolescent (psychoendocrine alteration) and postpartum depression, premenstrual syndrome. Low timely diagnostics of depressions, high incidence rate of somaticized CD are noted. In the structure of climacteric syndrome the psychoemotional disturbances predominate above neurovegetative and metabolic-endocrine or are combined with vegetative dysfunction. The participation in formation of CD (with predominance of mild/moderate severity) of neurohormonal, genetic, biochemical, social-environmental, psychological factors is shown. In the reviewed sources low mood, loss of previous priorities, decrease of productivity and concentration of attention, position of being unprotected, dependence, lack of confidence, self-humiliation, repentance, unbelief in future, insomnias, hypo-/hyperrexia with change of body mass are described in CD but there are no publications on suicidal ideation. It is indicated that CD can flow with hysteric- and nosophobic, somatohypochondriac and asthenohypochondriac component. The authors consider that somatization as an experience of climacteric stress leads to somaticized CD with accent on physical symptoms and repression of depression and anxiety although an association of specific somatic nosologies with symptoms of CD is not described. The association of CD with social-environmental factors (gender, education, profession, social position, financial wealth) is discussed, achievement of the woman is considered as a actor of reduction of CD risk. The authors are highly interested in search for genetic markers (heredity, suicides in relatives), impairment of neuromediator exchange (neurotransmitters serotonin, dopamine, adrenaline, and noradrenaline), neuromorphologic alterations in brain sensorimotor cortex (motor function, attention, perception, memory, and emotional-motivational response), hormonal disturbances (neuroendocrine and metabolic) and psychoneuroimmunological patterns of association with CD. Psychopharmacotherapy in CD is constructed with account for depressive symptoms (antidepressants of activating/sedative action in long-term maintenance regime), background and co-occurring diseases (adequate and pathogenetic and immunotherapy) with involvement in case of absence of contraindications of substitutive hormonotherapy (estrogen, progesterone). Beyond conventional schemes of the therapy the alternative therapy of CD (acupuncture, yoga, phytoestrogen collections, and food additives) is discussed. For heightening the efficiency and safety of the therapy of CD the training in detection of CD signs both for female patients and nurses, psychologists, social workers is proposed.

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Central Nervous System Stimulants and Drugs That Suppress Appetite

Kshatriya

Bello²

2017

Side Effects of Drugs Annual

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Armodafinil for fatigue associated with menopause

Abstract: These preliminary results suggest a therapeutic effect of armodafinil on fatigue affecting quality of life during menopause, and a potential benefit for other menopause-related symptoms.

Cited by 6 publications

References 30 publications

Psychological Climacteric Symptoms and Attitudes toward Menopause among Emirati Women

Psychological Climacteric Symptoms and Attitudes toward Menopause among Emirati Women

Depressive disorders in women of climacteric age (review of foreign literature for 2012–2016)

Central Nervous System Stimulants and Drugs That Suppress Appetite

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