Aristolochic acid nephropathy

Ji, Hongjian; Hu, Jingyin; Zhang, Guozhe; Song, Jianxiang; Zhou, Xiao‐Hua; Guo, Dan

doi:10.1097/md.0000000000026510

Cited by 13 publications

(4 citation statements)

References 33 publications

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“…Recent research has highlighted apoptotic and inflammatory mechanisms associated with AA-induced nephropathy. 33 Studies conducted in both human and rodent animal models have demonstrated that AAN is characterized by inflammation and damage to the renal tubules and interstitial tissue in the kidneys. 15,34,35 Our research, along with other prior investigations in zebrafish, has demonstrated that exposing zebrafish embryos to AA results in a significant increase in the expression of proinflammatory genes, including mpo and tnfα.…”

Section: Discussionmentioning

confidence: 99%

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Nephroprotective effects of coriander (Coriandrum sativum) leaves aqueous extracts in aristolochic acid‐intoxicated zebrafish embryos

Tsai,

Wang,

Lin

et al. 2024

Environmental Toxicology

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Coriander is a notable medicinal plant known for its diverse properties, including anti‐inflammatory, antioxidant, anticancer, analgesic, and anti‐diabetic effects. Despite its recognized health benefits, research on its nephroprotective properties is limited. This study aimed to investigate the potential nephroprotective properties of an aqueous extract derived from coriander leaves using an aristolochic acid‐intoxicated zebrafish model. To assess kidney abnormalities induced by aristolochic acid (AA), we utilized the transgenic line Tg(wt1b:egfp), which expresses green fluorescent protein (GFP) in the kidney. Our previous report indicated that AA exposure leads to acute renal failure in zebrafish characterized by kidney malformation and impaired renal function. However, pretreatment of coriander extract (CE) can mitigate kidney malformations induced by AA. In addition, CE pretreatment reduces the accumulation of red blood cells in the glomerular region. To verify the nephroprotective effects of CE, we analyzed renal function by measuring the glomerular filtration rate in zebrafish embryos. Results indicate that CE partially mitigates renal function impairment caused by AA exposure, suggesting its potential to attenuate AA‐induced renal failure. Mechanistically, pretreatment with CE reduces the expression of proinflammatory and proapoptotic genes induced by AA. This suggests that CE likely alleviates acute renal failure by reducing inflammation and apoptosis. As a result, we regard zebrafish as a valuable model for screening natural compounds that have the potential to alleviate AA‐induced nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

“…Recent research has highlighted apoptotic and inflammatory mechanisms associated with AA‐induced nephropathy 33 . Studies conducted in both human and rodent animal models have demonstrated that AAN is characterized by inflammation and damage to the renal tubules and interstitial tissue in the kidneys 15,34,35 .…”

Section: Discussionmentioning

confidence: 99%

Nephroprotective effects of coriander (Coriandrum sativum) leaves aqueous extracts in aristolochic acid‐intoxicated zebrafish embryos

Tsai,

Wang,

Lin

et al. 2024

Environmental Toxicology

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“…As early as in the 1960s, Chinese scholars had presented cases of acute renal failure caused by excessive doses of the Chinese herbal medicine Mutong [ 7 ]. In 1993, Belgian researchers first presented cases of chronic progressive kidney failure caused by consumption of weight loss pills containing aristolochic acid [ 8 ]. In the twenty-first century, aconitine poisoning was also frequently reported [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Multiorgan failure caused by Chinese herbal medicine Xanthii Fructus poisoning: a case report

Li,

Yu,

Shi

et al. 2023

BMC Complement Med Ther

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Background Xanthii Fructus was used in the treatment of rhinitis and related nasal disease. It is the most commonly used chemically active component in compounds formulated for the treatment of rhinitis. However, poisoning, resulting in serious consequences, can easily occur owing to cocklebur overdose, improper processing, or usage without processing. Case presentation We reported on a 55-year-old man who experienced allergic rhinitis for 2.5 years. He ingested unprocessed Xanthii Fructus for 2 months as treatment. However, he developed anorexia; nausea; abdominal pain; general weakness; hiccups; oliguria and anuria; significantly elevated serum alanine aminotransferase, aspartate aminotransferase, and creatinine levels; and abnormalities in blood coagulation series. Nutritional support; daily drugs for liver protection, gastric protection, inflammation reduction; fresh plasma; and cryoprecipitate infusion were administered. Continuous venovenous hemodialysis (Prismaflex ST100) was also administered. However, the patient’s multiple organ failure gradually worsened, ultimately leading to death. Conclusion Xanthii Fructus poisoning affects multiple systems, and its clinical manifestations are complex. Therefore, it is easily misdiagnosed and missed. Along with careful inquiry of medical and medication history, early diagnosis and intervention are vital for a successful treatment. It is also important to educate people and create awareness about this poisoning. Therefore, this intractable case has great clinical significance.

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“…Hence, the Aristolochia species have been excluded from the Chinese pharmacopeia and banned to utilize for medicinal purposes in many countries (Kim and Lim, 2019). Yet the conflict between the medicinal value and potential nephrotoxicity and teratogenicity makes the illegal addition of Aristolochia in medicines and health products still rampant (Maggini et al, 2018;Ji et al, 2021). Recently, modern studies gradually discovered the new bioactivities of Aristolochia species such as insecticidal, anti-bacterial, antinociceptive, and anti-inflammatory effects (Kuo et al, 2011;Salome et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Structural Variation of the Chloroplast Genome and Related Bioinformatics Tools

Kong

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Aristolochic acid nephropathy

Cited by 13 publications

References 33 publications

Nephroprotective effects of coriander (Coriandrum sativum) leaves aqueous extracts in aristolochic acid‐intoxicated zebrafish embryos

Nephroprotective effects of coriander (Coriandrum sativum) leaves aqueous extracts in aristolochic acid‐intoxicated zebrafish embryos

Multiorgan failure caused by Chinese herbal medicine Xanthii Fructus poisoning: a case report

Structural Variation of the Chloroplast Genome and Related Bioinformatics Tools

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