Aristolochic acid-induced accumulation of methylglyoxal and Nε-(carboxymethyl)lysine: An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy

Li, Yi Chieh; Tsai, Shin Han; Chen, Shih Ming; Chang, Ya Min; Huang, Tzu Chuan; Huang, Yiyan; Chang, Chen Tien; Lee, Jen Ai

doi:10.1016/j.bbrc.2012.06.049

Cited by 38 publications

(43 citation statements)

References 27 publications

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“…66 It binds to proteins that contribute to the morbidity of aging and diabetes mellitus, such as renal diseases. 67 A prospective, controlled study on chinchilla was conducted to determine the ototoxic effects of manuka honey. After 2 weeks of administration into the ears, the chochleae were removed for analysis.…”

Section: Issues Encounteredmentioning

confidence: 99%

Manuka honey: an emerging natural food with medicinal use

Patel

Cichello

2013

Nat. Prod. Bioprospect.

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Abstract:The health value of honey is universally acknowledged from time immemorial. Manuka (Leptospermum scoparium) is a tree, indigenous to New Zealand and South East Australia, and from the myrtle family, Myrtaceae. The honey produced from its flowers is a uni-floral honey largely produced in New Zealand. It is becoming increasingly popular as a functional food, seen in the aisles of health stores as its displays superior nutritional and phytochemistry profile over other varieties of honey. Examining existing research databases revealed its biological properties ranging from anti-oxidant, anti-inflammatory, anti-bacterial, anti-viral, anti-biotic and wound healing to immune-stimulatory properties. Methylglyoxal is the unique compound in the honey responsible for some of its potent anti-microbial properties. Further, propolis another component of honey contains chiefly flavonoids (i.e. galangin, pinocembrin), phenolic acids and their esters that may also contribute to its immuno-stimulant properties. Recent findings of the biological roles have been discussed with emphasis on the underlying mechanisms. The hurdles associated in its development as a functional food and also nutraceutical with future scopes have also been mentioned. Relevant data published in MEDLINE, Cochrane library, and EMBASE in the past decade have been gathered to formulate this review.

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Section: Issues Encounteredmentioning

confidence: 99%

Manuka honey: an emerging natural food with medicinal use

Patel

Cichello

2013

Nat. Prod. Bioprospect.

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“…Carbonyl stress involves other kinds of nephropathy, such as AN and AAN [13,16]. More studies are required to understand the role of MGO in progression of renal failure in different kind of model.…”

Section: Methylglyoxal and Nephropathy In Diabetic And Non-diabetic Mmentioning

confidence: 99%

“…The tissue or cellular regulation of MGO metabolism in response to different stress or damage conditions is not fully understood. Facing tissue damage, some diseases exhibit extremely high MGO levels locally, with only minor elevation of systemic MGO levels [13,16].…”

Section: Methylglyoxal Generation Metabolism and Damagementioning

confidence: 99%

“…One study group exhibits elevated MGO levels in renal tissue 2 weeks after AA exposure, accompanied by renal failure (established using blood and urine biochemistry). The AGEs in renal tissue are also present in AAN mice [13]. Low-molecular-weight chitosan is a known MGO-chelating agent, established by in vitro and in vivo experiments [14].…”

Section: Methylglyoxal Generation Metabolism and Damagementioning

confidence: 99%

“…They are well-known contributors to the development of diabetic complications. Recently, dicarbonyl stress has been established as a pathogenesis factor in diseases other than diabetes, such as renal failure [13][14][15][16][17], hypertension [18,19], and sepsis [20]. These diseases present normal blood sugar, yet they share some features with diabetes.…”

Section: Introductionmentioning

confidence: 99%

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Evolving Evidence of Methylglyoxal and Dicarbonyl Stress Related Diseases from Diabetic to Non-Diabetic Models

Wang¹,

Lee²,

Chou³

2015

Pharm Anal Acta

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Methylglyoxal (MGO), a byproduct of sugar and lipid metabolic processes, is a major glycating agent. This metabolite reacts with basic residues of proteins and promotes the formation of advanced glycation end products (AGEs). Although MGO and AGEs are widely discussed in the context of diabetes, until recently, MGO was thought to result from insufficient blood sugar control. A new report reveals that plasma MGO, and not blood sugar, distinguishes diabetic patients with no pain from those with pain. This ability brings to MGO a new applicability to disease diagnosis.Diseases with normal sugar conditions, such as hypertension, sepsis, and renal disease, are increasingly recognized as MGO-related. We review the role of MGO in drug-induced nephropathy, induction of hypertension by oral administration, and as a biomarker of sepsis. We also discuss the measurement of MGO and its stable metabolite d-lactate.The metabolism and pathogenic mechanisms of MGO need investigation in diverse disease models. Whether MGO can be considered as an individual pathological factor will be an interesting topic.

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Urinary d‐lactate levels reflect renal function in aristolochic acid‐induced nephropathy in mice

Huang

Chen

et al. 2013

Biomedical Chromatography

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Urinary d-lactate is highly correlated to diabetic nephropathy - a progressive kidney disease in renal glomeruli. In this study, we used a C3H/3e mouse model to investigate the relationship between urinary d-lactate and aristolochic acid nephropathy where the glomerular structure is not affected. The nephropathy was induced using intravenous injections of aristolochic acid at a dosage of 10 mg/kg per day for 5 days and was characterized biochemically and histologically. The urinary excretions of proteins, N-acetyl-β-d-glucosaminidase and serum creatinine were determined and connected to histological conventional findings. Urinary d-lactate was analyzed using column-switching high-performance liquid chromatography with fluorescence detection. The results showed a remarkable increase of urinary markers, including of urinary proteins and N-acetyl-β-d-glucosaminidase, and the histological examination confirmed a diagnosis of acute tubule necrosis. The ratio of d-lactate to creatinine in the urine of aristolochic acid-treated mice was approximately 36 times greater than that of the mice in the control group (p < 0.05). The ratios for the two groups of mice were 311.00 ± 71.70 and 8.60 ± 1.80 µmol/mmol creatinine, respectively. These data confirm in vivo that urinary d-lactate reflects renal injury conditions in aristolochic acid-treated mice and may be a marker for the assessment of nephropathy.

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Aristolochic acid-induced accumulation of methylglyoxal and Nε-(carboxymethyl)lysine: An important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy

Cited by 38 publications

References 27 publications

Manuka honey: an emerging natural food with medicinal use

Manuka honey: an emerging natural food with medicinal use

Evolving Evidence of Methylglyoxal and Dicarbonyl Stress Related Diseases from Diabetic to Non-Diabetic Models

Urinary d‐lactate levels reflect renal function in aristolochic acid‐induced nephropathy in mice

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