We appreciate the comment on our study on impact of previous, simultaneous or intravesical recurrence bladder cancer on prognosis of upper tract urothelial carcinoma (UTUC) after nephroureterectomy (1). We agree with Li and Chung that the incidence, carcinogenic factors, pathological characteristics of UTUC may differ between China and the U.S. For examples, it is reported that UTUC tends to be more female predominant in China, while it is more prevalent in males in the U.S. or European countries (2,3). Furthermore, tobacco smoking is a predominant risk factor for UTUC in the Western countries, but less than one fifth had this exposure in China (3). The use of traditional Chinese medicine containing aristolochic acid was more prevalent among Chinese, especially for female, and this may explain the observed gender differences among Chinese with UTUC (4-6). Moreover, UTUC tumors were found be more located in the ureter than in the renal pelvis (2). Several studies have revealed some distinctive prognostic factors to the Chinese population such as gender (3), tumor location (2,7) and aristolochic acid mutational signature (5).Regarding several concerns raised in the comment, our reply may perhaps clarify some of them. We agree on that the chronic kidney disease (CKD) stage and dialysis history, regimens of intravesical chemotherapy and follow-up schedule play important roles in the prognosis of UTUC.