Aristolochic acid and its derivatives as inhibitors of snake venom L-amino acid oxidase

Bhattacharjee, Payel; Bera, Indrani; Chakraborty, Subrata; Ghoshal, Nanda; Bhattacharyya, Debasish

doi:10.1016/j.toxicon.2017.08.003

Cited by 26 publications

(13 citation statements)

References 49 publications

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“…Kitag and A. sieboldii Miq (China), A. europaeum L. (Europe), and A. canadense L (Canada and USA) (Michl et al, 2017) are used medicinally. Herbs or products containing AAs are commonly used for treating cold, headache, aphthous stomatitis, inflammatory diseases, snake bites, and sexual problems (Li et al, 2010; Kuo et al, 2012; Michl et al, 2013; Bhattacharjee et al, 2017; Liang et al, 2017). Since nephrotoxicity and carcinogenicity of AAs have been recognized, the US Food and Drug Administration and regulatory authorities of some other countries have issued alerts against the use and import of products containing parts of Aristolochia.…”

Section: Aristolochic Acidsmentioning

confidence: 99%

Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms

et al. 2019

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Aristolochic acids (AAs) are a group of toxins commonly present in the plants of genus Aristolochia and Asarum , which are spread all over the world. Since the 1990s, AA-induced nephropathy (AAN) and upper tract urothelial carcinoma (UTUC) have been reported in many countries. The underlying mechanisms of AAN and AA-induced UTUC have been extensively investigated. AA-derived DNA adducts are recognized as specific biomarkers of AA exposure, and a mutational signature predominantly characterized by A→T transversions has been detected in AA-induced UTUC tumor tissues. In addition, various enzymes and organic anion transporters are involved in AA-induced adverse reactions. The progressive lesions and mutational events initiated by AAs are irreversible, and no effective therapeutic regimen for AAN and AA-induced UTUC has been established until now. Because of several warnings on the toxic effects of AAs by the US Food and Drug Administration and the regulatory authorities of some other countries, the sale and use of AA-containing products have been banned or restricted in most countries. However, AA-related adverse events still occur, especially in the Asian and Balkan regions. Therefore, the use of AA-containing herbal remedies and the consumption of food contaminated by AAs still carry high risk. More strict precautions should be taken to protect the public from AA exposure.

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Section: Aristolochic Acidsmentioning

confidence: 99%

Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms

et al. 2019

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“…phospholipase A2, L-amino acid oxidase), supporting traditional use of AA-containing preparations as antidote for snake bites (Ebrahimi et al, 2018;Bhattacharjee et al, 2017) and justifying a use of CT restricted to topic administration, and only in this indication.…”

Section: Discussionmentioning

confidence: 94%

Health risk associated with the oral consumption of “Chiniy-tref”, a traditional medicinal preparation used in Martinique (French West Indies): Qualitative and quantitative analyses of aristolochic acids contained therein

Riffault-Valois

Wattez

Langrand

et al. 2019

Toxicon

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“…The nitrophenanthrene carboxylic acid alkaloid aristolochic acid ( 11 ), found in species of Aristolochia (Aristolochiaceae) from India, has been reported as a promising antivenom agent. Previous studies report in vitro inhibitory activity against LAAO of D. russelii (19% inhibition- IC 50 = 33.6 µM) ( 145 ). It has also been shown that, in the venom of D. russelii , 11 inhibited (0.16 µM) the edema-inducing activity of the enzyme by 50% ( 146 ).…”

Section: Plant Products As Antivenom Agentsmentioning

confidence: 97%

Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations

et al. 2022

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Snakebite envenomations (SBEs) are a neglected medical condition of global importance that mainly affect the tropical and subtropical regions. Clinical manifestations include pain, edema, hemorrhage, tissue necrosis, and neurotoxic signs, and may evolve to functional loss of the affected limb, acute renal and/or respiratory failure, and even death. The standard treatment for snake envenomations is antivenom, which is produced from the hyperimmunization of animals with snake toxins. The inhibition of the effects of SBEs using natural or synthetic compounds has been suggested as a complementary treatment particularly before admission to hospital for antivenom treatment, since these alternative molecules are also able to inhibit toxins. Biodiversity-derived molecules, namely those extracted from medicinal plants, are promising sources of toxin inhibitors that can minimize the deleterious consequences of SBEs. In this review, we systematically synthesize the literature on plant metabolites that can be used as toxin-inhibiting agents, as well as present the potential mechanisms of action of molecules derived from natural sources. These findings aim to further our understanding of the potential of natural products and provide new lead compounds as auxiliary therapies for SBEs.

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Aristolochic acid and its derivatives as inhibitors of snake venom L-amino acid oxidase

Cited by 26 publications

References 49 publications

Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms

Systematic Overview of Aristolochic Acids: Nephrotoxicity, Carcinogenicity, and Underlying Mechanisms

Health risk associated with the oral consumption of “Chiniy-tref”, a traditional medicinal preparation used in Martinique (French West Indies): Qualitative and quantitative analyses of aristolochic acids contained therein

Plant-Derived Toxin Inhibitors as Potential Candidates to Complement Antivenom Treatment in Snakebite Envenomations

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