ARISTOLOCHIASÄUREN AUSARISTOLOCHIA MANSHURIENSIS

Abstract

The stems of Aristolochia manshuriensis KOMAROV (syn. Hocquartia manshuriensis NOKAI) from plants, collected in the province Kang-Won-DolKorea, have been shown to contain aristolochic acid I and 11. In addition, the presence of debilic acid is assumed.

Analysis of products suspected of containing Aristolochia or Asarum species

“…Aristolochia fangchi is known to contain a series of nephrotoxic alkaloids called aristolochic acids, namely I and II ( Fig. 1) (Tada et al, 1969;Rucker and Chung, 1975;Cateni and Mamolo, 1992;Mengs and Stotzem, 1993;Vanhaelen et al, 1994;Vanherweghem et al, 1993). In 1996, the renal tissue from five of the Belgian patients tested positive for aristolochic acid related DNA adducts (Schmeiser et al, 1996).…”

Interaction studies of aristolochic acid I with human serum albumin and the binding site of aristolochic acid I in subdomain IIA

“…AA-containing herbs have been used as medicine in obstetrics and in the treatment of snake bites. The plant extracts have also been used for the therapy of arthritis, gout, rheumatism, and festering wounds [11,12]. The anti-inflammatory properties of AA had rendered them lead compounds for pharmaceutical companies in Germany for 20 years until they were observed to be carcinogenic in rats [13].…”

Structure activity relationships of aristolochic acid analogues: Toxicity in cultured renal epithelial cells

“…The plant extracts have also been used for the therapy of arthritis, gout, rheumatism, and festering wounds [2,3]. The antiinflammatory properties of AA have encouraged its use in various drug formulations in Germany [4,5] until it was identified as a potential carcinogen in rodents by Mengs [6,7] in late 1980s.…”