Aripiprazole-Induced Persistent Hiccup: A Case Report and Review of the Literature

Serafini, Gianluca; Piccinini, Giulia; Visimberga, Samantha; Cervetti, Alice; Murri, Martino Belvederi; Monacelli, Fiammetta; Pompili, Maurizio; Amore, Mario

doi:10.24869/psyd.2019.26

Cited by 7 publications

(10 citation statements)

References 12 publications

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“…Aripiprazole has also been reported to induce persistent hiccup. Aripiprazole is a psychoactive compound acting as a dopamine D 2 partial agonist, serotonin 5-HT(1 A ) partial agonist and serotonin 5-HT(2 A ) antagonist [21].…”

Section: Physiological Mechanism Of Hiccupmentioning

confidence: 99%

Intraoperative Laryngeal Mask Airway-Related Hiccup: An Overview

Mathew

Shen

Liu

2019

Transl Perioper & Pain Med

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Hiccup is an involuntary contraction of the diaphragm and intercostal muscles resulting in sudden inspiration and closure of the glottis. The presence of hiccup in the perioperative period can be a challenging problem. Sudden movements of the patient from hiccups can interfere preoperative diagnostic procedures, intraoperative hiccup may delay the beginning of surgery, interfere with the surgical process, and affect intraoperative monitoring, and postoperative hiccup may affect would healing and hemodynamic stability. Hiccup can lead to have increased aspiration risk. Hiccup are is an incompletely understood phenomenon with multiple etiologies. Intraoperative hiccup related to laryngeal mask airway placement has been reported, and it presents unique challenges in diagnosis and management. Both pharmacological and non-pharmacological interventions have been utilized with various level of success. All treatment strategies are primarily aimed at interrupting the hiccup reflex arc.

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Section: Physiological Mechanism Of Hiccupmentioning

confidence: 99%

Intraoperative Laryngeal Mask Airway-Related Hiccup: An Overview

Mathew

Shen

Liu

2019

Transl Perioper & Pain Med

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“…Hiccups are caused by a sudden, involuntary powerful spasmodic contraction of the diaphragm and intercostal muscles. It can be divided into three categories based on their duration: acute hiccups last for less than 48 hours, persistent hiccups last for more than 48 hours and intractable hiccups last for more than 1 month 2…”

Section: Discussionmentioning

confidence: 99%

Rare case report of moxifloxacin-induced persistent hiccups

Zhou

Fei

2023

Eur J Hosp Pharm

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Moxifloxacin is a broad-spectrum antimicrobial agent that is commonly used in clinical practice. Here we report an unusual case of a patient with persistent hiccups caused by moxifloxacin. A man aged in his 40s was treated with moxifloxacin for tuberculous pleurisy. Hiccups occurred 2 hours after intravenous injection of moxifloxacin and lasted into evening. On the second day after injection, hiccups occurred again and made it difficult for him to fall asleep. The clinician ruled out gastrointestinal disease, nervous system disease, electrolyte disturbance and other factors. On assessing causality of the adverse drug reaction, the Naranjo scale for moxifloxacin was six, indicating a probable relationship of hiccups with moxifloxacin. Hiccups stopped 2 min after intramuscular injection of metoclopramide. To our knowledge, this is the first case report about moxifloxacin-induced persistent hiccups. Clinicians should be aware of the rare adverse reaction.

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“…In our case, patient Mr. Z had a history of cocaine abuse, which stopped a few months before admission but had previously lasted for years. Hiccups were the first iatrogenic adverse effect reported by the patient, and they are a known side effect of aripiprazole [63]. While the reason for this effect is not completely clear, it is thought to be related to dopaminergic dysregulation and considered to be within the EPS group [64].…”

Section: Discussionmentioning

confidence: 99%

Psychomotor Symptoms in Chronic Cocaine Users: An Interpretative Model

Cenci

Carbone

Callegari

et al. 2022

IJERPH

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According to the latest estimates, there are around 24.6 million cocaine users worldwide, and it is estimated that around a quarter of the population worldwide has used cocaine at some point in their lifetime. It follows that such widespread consumption represents a major risk for public health. Long-term use of cocaine, in addition to being related to many cerebral and cardiovascular diseases, is increasingly associated with a higher incidence of psychomotor symptoms and neurodegenerative disorders. In recent years, numerous studies have shown an increased risk of antipsychotic-induced extrapyramidal symptoms (EPSs) in patients with psychotic spectrum disorders comorbid with psychostimulant misuse, particularly of cocaine. In the present paper, we describe the case of a young patient on his first entry into a psychiatric setting with previous cocaine misuse who rapidly presented psychomotor symptoms and was poorly responsive to symptomatic therapy consisting of benzodiazepines and anticholinergics, in relation to the introduction of various antipsychotics (first, second, and third generation). Furthermore, we propose neurobiological mechanisms underlying the hypothesized increased vulnerability to psychomotor symptoms in chronic cocaine abusers. Specifically, we supposed that the chronic administration of cocaine produces important neurobiological changes, causing a complex dysregulation of various neurotransmitter systems, mainly affecting subcortical structures and the dopaminergic and glutamatergic pathways. We believe that a better understanding of these neurochemical and neurobiological processes could have useful clinical and therapeutic implications by providing important indications to increase the risk–benefit ratio in pharmacological choice in patients with psychotic spectrum disorders comorbid with a substance use disorder.

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Aripiprazole-Induced Persistent Hiccup: A Case Report and Review of the Literature

Cited by 7 publications

References 12 publications

Intraoperative Laryngeal Mask Airway-Related Hiccup: An Overview

Intraoperative Laryngeal Mask Airway-Related Hiccup: An Overview

Rare case report of moxifloxacin-induced persistent hiccups

Psychomotor Symptoms in Chronic Cocaine Users: An Interpretative Model

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