Aripiprazole in Treating a Manic Episode Associated With Hydrocephalus

Lee, Chuan-Ya; Chou, Yuan-Hwa

doi:10.4088/pcc.10l01018yel

Cited by 3 publications

(1 citation statement)

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“…Neuropsychiatric manifestations, although uncommon, have been described in association with hydrocephalus (a condition caused by obstruction in drainage, decreased absorption or excess production of cerebrospinal fluid). Normal Pressure Hydrocephalus (NPH) may present with its classic progressive triad (abnormal gait, ataxic/apractic dementia and urinary incontinence) [ 1 ], as paranoid psychosis [ 2 , 3 ] or as a mood disorder, such as depressive episodes, manic episodes [ 4 – 6 ], or mood cycling [ 7 , 8 ]. As far as we know, there is no knowledge of mood episodes with the onset after hydrocephalus resolution.…”

Section: Introductionmentioning

confidence: 99%

Manic Episode after Ventricular-Peritoneal Shunt Replacement in a Patient with Radiation-Induced Hydrocephalus: The Role of Lifetime Subthreshold Bipolar Features

Callari

Mantua

Benvenuti

et al. 2014

Case Reports in Psychiatry

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We present a case report of a woman hospitalized for a ventricular-peritoneal shunting replacement, who developed a manic episode with psychotic symptoms after hydrocephalus resolution. We have no knowledge of cases of manic episodes due to hydrocephalus resolution by ventricular-peritoneal shunt replacement, although previous case reports have suggested that hydrocephalus might induce rapid-onset affective episodes or mood cycles. The patient's history revealed the lifetime presence of signs and features belonging to the subthreshold bipolar spectrum, in absence of previous full-blown episodes of a bipolar disorder. Our hypothesis is that such lifetime sub-threshold bipolar features represented precursors of the subsequent full-blown manic episode, triggered by an upregulated binding of striatum D2 receptors after the ventricular-peritoneal shunt replacement.

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Section: Introductionmentioning

confidence: 99%

Manic Episode after Ventricular-Peritoneal Shunt Replacement in a Patient with Radiation-Induced Hydrocephalus: The Role of Lifetime Subthreshold Bipolar Features

Callari

Mantua

Benvenuti

et al. 2014

Case Reports in Psychiatry

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The Role of the Craniocervical Junction in Craniospinal Hydrodynamics and Neurodegenerative Conditions

Flanagan

2015

Neurology Research International

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The craniocervical junction (CCJ) is a potential choke point for craniospinal hydrodynamics and may play a causative or contributory role in the pathogenesis and progression of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, MS, and ALS, as well as many other neurological conditions including hydrocephalus, idiopathic intracranial hypertension, migraines, seizures, silent-strokes, affective disorders, schizophrenia, and psychosis. The purpose of this paper is to provide an overview of the critical role of the CCJ in craniospinal hydrodynamics and to stimulate further research that may lead to new approaches for the prevention and treatment of the above neurodegenerative and neurological conditions.

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