Aripiprazole in Pregnancy and Lactation

Lutz, Ulrich; Hiemke, Christoph; Wiatr, Gerlinde; Farger, Gisbert; Arand, Jörg; Wildgruber, Dirk

doi:10.1097/jcp.0b013e3181d27c7d

Cited by 42 publications

(19 citation statements)

References 14 publications

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“…In fact, various drugs that substantially decrease PRL similarly impair lactation (Hutchison and Sill 1981;Colao et al 2000). Specifically, this has also been the case with ARI, whose use throughout pregnancy has been associated with alactogenesis (Mendhekar et al 2006a,b;Mervak et al 2008;Lutz et al 2010;Gentile et al 2011;Nguyen et al 2011;Watanabe et al 2011). This failure to lactate following pregnancy also characterizes women with an isolated PRL deficiency (Turkington 1972;Spitz et al 1977;Kauppila 1987;Falk 1992;Douchi et al 2001), a deficiency that can be the result of a genetic defect (Zargar et al 1997).…”

Section: Introductionmentioning

confidence: 99%

Prolactin Serum Concentrations During Aripiprazole Treatment in Youth

Safer

Calarge

Safer

2013

Journal of Child and Adolescent Psychopharmacology

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Objective: This study aimed to: document the extent of the reduction of serum prolactin (PRL) levels induced by aripiprazole (ARI) treatment in children and adolescents, compare this effect by age group, and shed light on this phenomenon. Methods: PRL serum levels in unmedicated subjects were compared to those in subjects treated with aripiprazole to calculate the rate of subnormal PRL levels during aripiprazole treatment. Next, a literature search was performed to better understand the effects of dopaminergic drugs on PRL levels by age group. Results: Sixty percent of those treated with aripiprazole exhibited subnormal PRL serum levels versus 8% of unmedicated subjects. The rate of PRL subnormality in response to aripiprazole was half as frequent in adolescents and was minimal in adults. The drug-induced reduction of PRL serum levels became more prominent with increasing doses of aripiprazole and with an increased treatment duration. Conclusions: With the increasing use of aripiprazole in the United States population, it is important that future research be conducted to explore the potential sequelae of subnormal PRL serum levels in children and adolescents.

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Section: Introductionmentioning

confidence: 99%

Prolactin Serum Concentrations During Aripiprazole Treatment in Youth

Safer

Calarge

Safer

2013

Journal of Child and Adolescent Psychopharmacology

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“…In a study of 26 infants, two breastfed infants had adverse events attributed to olanzapine, which included jaundice, sedation, diaper rash, protruding tongue, poor , 2012;Gentile, 2004Gentile, , 2008Illet et al, 2004;Lactmed , 2012b,c,d,e,f,g;Lutz et al, 2010;Moretti et al, 2003;Pointek et al, 2000;Schlotterbeck, 2007;Wisner & James, 1998;Yonkers et al, 2004. Stowe, 2007; sucking, shaking, and temporary motor developmental delay (Gentile, 2008;Lactmed, 2012e).…”

Section: Olanzapinementioning

confidence: 99%

“…There is one known case report of normal infant growth at age 3 months in a child exposed to aripiprazole via breastfeeding (Lutz et al, 2010).…”

Section: Aripiprazolementioning

confidence: 99%

Treatment Considerations During Lactation for Adolescents with Bipolar Disorder

Moratschek¹,

Lytle²,

Hatters‐Friedman³

2013

Child and Adolescent Psychopharmacology News

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“…The little that is known about the effects of aripiprazole in pregnancy is based on case reports (Lutz et al, 2010). There is one case of unexplained fetal tachycardia (Mendhekar, Sunder, & Andrade, 2006), but no major malformations were reported.…”

Section: Aripiprazolementioning

confidence: 99%