Aripiprazole

Ardiana, Febry; Lestari, Maria Lucia Ardhani Dwi; Indrayanto, Gunawan

doi:10.1016/b978-0-12-407691-4.00002-2

Cited by 13 publications

(7 citation statements)

References 32 publications

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“…In the case of ARP, the thermogram (gray line) shows three endothermic peaks with onsets at c.a. 137 °C, 141 °C, and 151 °C, which can be associated with melting of forms II, III, and I, respectively [ 59 ]. The small exothermic effect, preceding the melting point of form I indicates the phase transition from form III to form I [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

The Impact of the Preparation Method on the Properties of Orodispersible Films with Aripiprazole: Electrospinning vs. Casting and 3D Printing Methods

et al. 2021

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Orodispersible films (ODFs) address the needs of pediatric and geriatric patients and people with swallowing difficulties due to fast disintegration in the mouth. Typically, they are obtained using the solvent casting method, but other techniques such as 3D printing and electrospinning have already been investigated. The decision on the manufacturing method is of crucial importance because it affects film properties. This study aimed to compare electrospun ODFs containing aripiprazole and polyvinyl alcohol with films prepared using casting and 3D printing methods. Characterization of films included DSC and XRD analysis, microscopic analysis, the assessment of mechanical parameters, disintegration, and dissolution tests. Simplified stability studies were performed after one month of storage. All prepared films met acceptance criteria for mechanical properties. Electrospun ODFs disintegrated in 1.0 s, which was much less than in the case of other films. Stability studies have shown the sensitivity of electrospun films to the storage condition resulting in partial recrystallization of ARP. These changes negatively affected the dissolution rate, but mechanical properties and disintegration time remained at a desirable level. The results demonstrated that electrospun fibers are promising solutions that can be used in the future for the treatment of patients with swallowing problems.

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Section: Resultsmentioning

confidence: 99%

The Impact of the Preparation Method on the Properties of Orodispersible Films with Aripiprazole: Electrospinning vs. Casting and 3D Printing Methods

et al. 2021

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“…It is worth noting that aripiprazole is one of the best-selling crystalline pharmaceuticals. ARP belongs to a new generation of antipsychotic drugs . It is used in the treatment of schizophrenia and acute manic and mixed episodes associated with bipolar disorders. , From the chemical point of view, ARP can be classified as a benzisoxazole derivative containing a dihydrocarbostyril ring and a dichlorophenylpiperazinyl unit located on two opposite ends of the molecule and the butoxyl chain in between.…”

Section: Introductionmentioning

confidence: 99%

Influence of Polymeric Additive on the Physical Stability and Viscoelastic Properties of Aripiprazole

et al. 2019

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In this article, we investigated aripiprazole + Kollidon VA64 (ARP/KVA) and aripiprazole + Soluplus (ARP/SOP) amorphous solid dispersions. Thermal properties of all prepared systems have been examined by means of differential scanning calorimetry (DSC). Compositions revealing the recrystallization tendency were subsequently investigated by means of broadband dielectric spectroscopy (BDS). On the basis of dielectric data, the physically stable drug–polymer concentrations have been found. Finally, these systems have been investigated by rheology, which enables us to determine the minimal temperature required for dissolving the drug in the polymeric matrix, as well as the temperature dependence of the sample viscosity. Our investigations have shown that the amorphous form of the investigated antipsychotic drug might be effectively stabilized by both employed polymers. However, due to the better stabilization effect and the more favorable rheological properties, KVA proved to be a better polymeric excipient for extrusion of amorphous aripiprazole.

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“… 18 Aripiprazole exhibited partial agonist properties over dopamine D2 receptor and had serotonin 5-HT1A-receptor partial agonist as well as 5-HT2A-receptor antagonist properties. 19 Therefore, these drugs exhibit complex mechanisms in their interaction with the nervous system which in several ways remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Behavioral Mechanisms That Depend on Dopamine and Serotonin in Caenorhabditis elegans Interact With the Antipsychotics Risperidone and Aripiprazole

et al. 2018

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The neurotransmitters dopamine and serotonin participate in specific behavioral neuromuscular mechanisms in the nematode Caenorhabditis elegans. Dopamine is involved in the gentle touch response and serotonin in the pharyngeal pumping rate. In its genome, the worm presents genes encoding dopamine and serotonin receptors orthologous to those of human genes. Risperidone and aripiprazole are a class of drugs known as atypical antipsychotics commonly used to treat schizophrenia, bipolar disorder, and irritability associated with autism. Risperidone is an antagonist of the dopamine D2 and serotonin 5-HT2A receptors. Aripiprazole functions as a partial agonist of the dopamine D2 receptor and as a partial agonist and antagonist of 5-HT1A and 5-HT2A serotonin receptors, respectively. Our results show that risperidone and aripiprazole alter the touch response and pharyngeal pumping in wild-type worm animals. Furthermore, in the presence of the drugs, both behaviors change to varying degrees in dopamine (dop-1, dop-2, and dop-3), serotonin (ser-1), and tyramine (ser-2) receptor-deficient mutants. This variation in response reveals specific targets for these antipsychotics in the nematode. Interestingly, their effect on behavior persisted to some extent in successive generations, indicating that they might induce epigenetic changes throughout development. Sodium butyrate, a histone deacetylase inhibitor, eliminated the consecutive generation effect of both drugs. In addition, these transgenerational effects were also abolished after the dauer stage. These observations suggest that risperidone and aripiprazole, in addition to interacting with specific receptors impairing the function of the nervous system of the nematode, may lead to the deposition of long-lasting epigenetic marks.

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Aripiprazole

Cited by 13 publications

References 32 publications

The Impact of the Preparation Method on the Properties of Orodispersible Films with Aripiprazole: Electrospinning vs. Casting and 3D Printing Methods

The Impact of the Preparation Method on the Properties of Orodispersible Films with Aripiprazole: Electrospinning vs. Casting and 3D Printing Methods

Influence of Polymeric Additive on the Physical Stability and Viscoelastic Properties of Aripiprazole

Behavioral Mechanisms That Depend on Dopamine and Serotonin in Caenorhabditis elegans Interact With the Antipsychotics Risperidone and Aripiprazole

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