Aripiprazole Augmentation in Clozapine-Associated Obsessive-Compulsive Symptoms

Villari, Vincenzo; Frieri, Tiziana; Fagiolini, Andrea

doi:10.1097/jcp.0b013e31821927d8

Cited by 20 publications

(12 citation statements)

References 5 publications

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“…Various researchers reported the remission of schizophrenia psychosis and strong reduction of obsessive-compulsive disorder after adding clozapine to aripiprazole [11,12]. The choice of aripiprazole as an adjunctive treatment was suggested because of its mechanism of action [13].…”

Section: Discussionmentioning

confidence: 99%

Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia

et al. 2013

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ObjectivePatients with schizophrenia often experience comorbid obsessive-compulsive symptoms. Within these patients, a significant subgroup developed secondary obsessive-compulsive symptoms during treatment with clozapine.MethodIn this paper, we report on four cases in which adjunctive therapy with aripiprazole was tested to alleviate obsessive-compulsive symptoms in schizophrenia.ResultsAll four patients had a significant improvement in obsessive-compulsive symptoms. The combination of clozapine and aripiprazole was well tolerated.ConclusionThis case series demonstrates the clinical efficacy of aripiprazole adjunctive therapy with clozapine in schizophrenic patients with comorbid obsessive-compulsive symptoms. Larger-sampled and controlled studies are required in order to test and confirm these observations.

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Section: Discussionmentioning

confidence: 99%

Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia

et al. 2013

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“…10 In addition, there are case reports describing the use of aripiprazole augmentation in the treatment of clozapine-associated OCS. 11,12 In all nine cases, patients developed OCS or experienced a worsening of OCS after initiating clozapine, and in all cases the addition of aripiprazole (average dose 22.9 mg daily in the study by Englisch and colleagues 12 and 30 mg daily in the study by Vallari and colleagues 11 ) was associated with improvement in OCS. Englisch showed a decrease in total Y-BOCS score from 18.7 to 12.43 after initiation of aripiprazol, with a mean observation period of 9.7 weeks.…”

Section: Discussionmentioning

confidence: 99%

A 44-Year-Old Woman with Intrusive Thoughts

Betcher¹,

Nelson²

2012

Psychiatric Annals

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“…6,9 Aripiprazole has been used successfully to reduce OCS where SSRIs have failed. 14 In case 2 it has been shown that aripiprazole can be combined with an SSRI for difficult cases.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, aripiprazole has been used to counteract the effects of OCS occurring with clozapine and olanzapine. 6,9 Clozapine is the antipsychotic most associated with OCS. 2,3 One study showed that use of clozapine had twice the risk of being associated with OCS compared with haloperidol, and although the result was found to be statistically insignificant, the severity of the OCS was significant with clozapine.…”

mentioning

confidence: 99%

Obsessive‐compulsive symptoms: a side‐effect of antipsychotic treatment

Ukaegbu¹,

Dunne²,

Getachew³

2016

Prog Neurol Psychiatry

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Obsessive‐compulsive symptoms (OCS) secondary to antiserotonergic antipsychotic treatment of schizophrenia appear to have a significant prevalence from previous studies but can be very difficult to detect as they are overshadowed by the diagnosis of schizophrenia. Here, the authors describe three cases where patients have developed OCS after starting risperidone in one case, and clozapine in two other cases and how significant improvements can be achieved with SSRIs and, if necessary, cognitive behavioural therapy (CBT).

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Aripiprazole Augmentation in Clozapine-Associated Obsessive-Compulsive Symptoms

Cited by 20 publications

References 5 publications

Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia

Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia

A 44-Year-Old Woman with Intrusive Thoughts

Obsessive‐compulsive symptoms: a side‐effect of antipsychotic treatment

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