ARID5B gene rs10821936 polymorphism is associated with childhood acute lymphoblastic leukemia: a meta-analysis based on 39,116 subjects

Abstract

Childhood acute lymphoblastic leukemia (ALL) is the leading cause of cancer-related deaths among children. Two recent genome-wide association studies and several replicated studies have provided convincing evidence that inherited genetic variation in ARID5B contributes to childhood ALL predisposition. In the present study, we performed a meta-analysis to systematically summarize the association between ARID5B genetic polymorphism and the risk for ALL. We conducted a search of case-control studies on the association of ARID5B genetic polymorphisms with susceptibility to ALL in PubMed, EMBASE, Wanfang database in China, and Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis. ALL risk associated with ARID5B genetic polymorphism was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Nine articles including 13 case-control studies were included in the present meta-analysis. We found that rs10821936 polymorphism in ARID5B gene was associated with increased risk for ALL (P< 0.0001; OR = 1.27; 95%CI, 1.17-1.37). This meta-analysis suggests that ARID5B genetic polymorphism was associated with the increased risk of ALL.

Association Between PIP4K2A Polymorphisms and Acute Lymphoblastic Leukemia Susceptibility

“…After the extensive replication studies, some loci can be validated in all independent cohorts (eg, ARID5B ), whereas inconsistent associations were noticed in other loci (eg, PIP4K2A ), mostly due to small sample size and diverse patient characteristics. Systematic review and meta-analyses have been conducted for signals at ARID5B , IKZF1 , and CEBPE loci, 16 – 18 but not for PIP4K2A-BMI1 locus, which was firstly identified in our multiethnic GWAS. 5 Under this case, meta-analyses acted as a powerful tool to figure out the affecting factors, and potentially provided a clue on searching causal variants.…”

FHIT promoter DNA methylation and expression analysis in childhood acute lymphoblastic leukemia

“…In all cases of childhood leukemia, ~80% are ALL, which represents ~25% of cancers in children diagnosed <15 years of age in the United States in 2014 (2). Although the etiology of ALL is largely unknown, it has been proposed that multiple gene alterations, including inactivation of tumor suppressor genes, activation of proto-oncogenes and chromosomal rearrangements, in addition to gene-environmental interplay, are involved in disease development (1,3,4). Chromosomal abnormalities, including homozygous deletions and loss of heterozygosity, are among the most common characteristics of human tumors.…”

Association of ARID5B gene variants with acute lymphoblastic leukemia in Yemeni children

“…A recent meta-analysis study of 13 case-control studies involving 7147 patients and 31,969 controls reported that ARID5B rs10821936 SNP is associated with a high risk for ALL. 36 Functional studies are needed to explore how this SNP contributes to the increased risk of ALL. Due to conflicting studies relating to possible genderspecific associations with ALL, a stratified analysis of ALL between males and females was also performed.…”